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11BETA-PROSTAGLANDIN E1

Product Name
11BETA-PROSTAGLANDIN E1
CAS No.
27415-26-5
Chemical Name
11BETA-PROSTAGLANDIN E1
Synonyms
8-epi-PGF2α;(5Z,8β,9α,11α,13E,15S)-9,11,15-trihydroxyprosta-5,13-dien-1-oic Acid;15-F2t-IsoP;8-Iso-PGF2α;8-ISOPROSTANE;IPF2ALPHA-III;15-F2t-IsoP-d9;8-epi-PGF2α-d9;8-Iso-PGF2α-d9;8-EPI PGF2ALPHA
CBNumber
CB7701867
Molecular Formula
C20H34O5
Formula Weight
354.48
MOL File
27415-26-5.mol
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11BETA-PROSTAGLANDIN E1 Property

Boiling point:
531.0±50.0 °C(Predicted)
Density 
1.153±0.06 g/cm3(Predicted)
storage temp. 
Store at -20°C
solubility 
DMF: >100 mg/ml; DMSO: >100 mg/ml; Ethanol: >100 mg/ml; PBS pH 7.2: 3 mg/ml
form 
A crystalline solid
pka
4.76±0.10(Predicted)
color 
White to off-white
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Danger
Hazard statements

H302Harmful if swallowed

H360May damage fertility or the unborn child

Precautionary statements

P201Obtain special instructions before use.

P202Do not handle until all safety precautions have been read and understood.

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P270Do not eat, drink or smoke when using this product.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P301+P312IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.

P308+P313IF exposed or concerned: Get medical advice/attention.

P330Rinse mouth.

P405Store locked up.

P501Dispose of contents/container to..…

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N-Bromosuccinimide Price

Cayman Chemical
Product number
16350
Product name
8-iso Prostaglandin F2α
Purity
≥99%
Packaging
1mg
Price
$164
Updated
2024/03/01
Cayman Chemical
Product number
16350
Product name
8-iso Prostaglandin F2α
Purity
≥99%
Packaging
5mg
Price
$692
Updated
2024/03/01
Cayman Chemical
Product number
25903
Product name
8-iso Prostaglandin F2α MaxSpec® Standard
Packaging
100μg
Price
$214
Updated
2024/03/01
Cayman Chemical
Product number
16350
Product name
8-iso Prostaglandin F2α
Purity
≥99%
Packaging
10mg
Price
$1221
Updated
2024/03/01
TRC
Product number
P838620
Product name
8-epi-ProstaglandinF2α
Packaging
10mg
Price
$10725
Updated
2021/12/16
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11BETA-PROSTAGLANDIN E1 Chemical Properties,Usage,Production

Description

8-iso PGF2α is an isoprostane produced by the non-enzymatic peroxidation of arachidonic acid in membrane phospholipids. It is present in human plasma in two distinct forms - esterified in phospholipids and as the free acid. The ratio of these two forms is approximately 2:1, with a total plasma 8-iso PGF2α level of about 150 pg/ml in normal volunteers. In normal human urine, 8-iso PGF2α levels are about 180-200 pg/mg of creatinine. 8-iso PGF2α is a weak TP receptor agonist in vascular smooth muscle. Conversely, 8-iso PGF2α inhibits platelet aggregation induced by U-46619 (10−6 M) and I-BOP (3 x 10−7 M) with IC50 values of 1.6 x 10−6 M and 1.8 x 10−6 M, respectively.

Description

8-iso Prostaglandin F2α (8-iso PGF2α) is an isoprostane produced by the non-enzymatic peroxidation of arachidonic acid in membrane phospholipids. It is present in human plasma in two distinct forms - esterified in phospholipids and as the free acid. The ratio of these two forms is approximately 2:1, with a total plasma 8-iso PGF2α level of about 150 pg/ml in normal volunteers. In normal human urine, 8-iso PGF2α levels are about 180-200 pg/mg of creatinine. 8-iso PGF2α is a weak TP receptor agonist in vascular smooth muscle. Conversely, 8-iso PGF2α inhibits platelet aggregation induced by U-46619 (10−6 M) and I-BOP (3 x 10−7 M) with IC50 values of 1.6 x 10−6 M and 1.8 x 10−6 M, respectively.

8-iso Prostaglandin F2α MaxSpec® standard is a quantitative grade standard of 8-iso Prostaglandin F2α that has been prepared specifically for mass spectrometry and related applications where quantitative reproducibility is required. The solution has been prepared gravimetrically and is supplied in a deactivated glass ampule sealed under argon. The concentration was verified by comparison to an independently prepared calibration standard. This 8-iso Prostaglandin F2α MaxSpec® standard is guaranteed to meet identity, purity, stability, and concentration specifications and is provided with a batch-specific certificate of analysis. Ongoing stability testing is performed to ensure the concentration remains accurate throughout the shelf life of the product. Note: The amount of solution added to the vial is in excess of the listed amount. Therefore, it is necessary to accurately measure volumes for preparation of calibration standards. Follow recommended storage and handling conditions to maintain product quality.

Uses

(8-epi-prostaglandin F2a) A major metabolite of PGF2α. A prostaglandin derivative used as a biomarker in the diagnosis and treatment of cardiovascular-related diseases as well as biomarkers of total body oxidative stress.

Uses

A major metabolite of PGF2α. A prostaglandin derivative used as a biomarker in the diagnosis and treatment of cardiovascular-related diseases as well as biomarkers of total body oxidative stress.

Definition

ChEBI: A prostanoid that is prostaglandin F2alpha having inverted stereochemistry at the 8-position.

11BETA-PROSTAGLANDIN E1 Preparation Products And Raw materials

Raw materials

Preparation Products

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11BETA-PROSTAGLANDIN E1 Suppliers

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27415-26-5, 11BETA-PROSTAGLANDIN E1Related Search:

Prostaglandin F2a Isoprostane Related Compound 1 8-ISOPROSTANE-D4 2,3-dinor-5,6-dihydro-15-F-isoprostane 8-ISOPROSTANE-D4 [3H]-8-ISOPROSTANE 8,12-iso-isoprostane F2alpha-VI 8,12-iso-isoprostane F2alpha-III

  • 9ALPHA, 11ALPHA15S-TRIHYDROXY-(8BETA)-PROSTA-5Z, 13E-DIEN-1-OIC ACID
  • 8-ISOPROSTANE
  • 8-EPI PROSTAGLANDIN F2ALPHA
  • 8-EPI PGF2ALPHA
  • 8-ISO PROSTAGLANDIN F2ALPHA
  • (Z)-7-[(1S,2S,3R,5S)-3,5-dihydroxy-2-[(E,3S)-3-hydroxyoct-1-enyl]cyclopenty
  • 8-Isoprostaglandin F2a
  • 8-ISOPROSTAGLANDIN F2ALPHA, >99%
  • 8-epi-Prostaglandin F2α
  • 8-iso Prostaglandin F2α
  • (5Z,8β,9α,11α,13E,15S)-9,11,15-trihydroxyprosta-5,13-dien-1-oic Acid
  • 15(S)-8-Iso-PGF2α
  • 15-F2t-IsoP
  • 15-F2t-Isoprostane
  • 8-epi-PGF2α
  • 8-Iso-PGF2α
  • Isoprostaglandin F2α type-III
  • (5Z,8β,9α,11α,13E,15S)-9,11,15-trihydroxyprosta-5,13-dien-1-oic Acid-d9
  • 15-F2t-IsoP-d9
  • 15-F2t-Isoprostane-d9
  • 7-[3,5-Dihydroxy-2-(3-hydroxy-1-octenyl)cyclopentyl]-5-Heptenoic Acid-d9
  • 8-epi-PGF2α-d9
  • 8-Iso-PGF2α-d9
  • 8-iso-Prostaglandin F2α-d9
  • 8-Isoprostaglandin F2α-d9
  • Isoprostaglandin F2α type-III-d9
  • 8-epi-Prostaglandin F<sub>2α</sub>
  • IPF2ALPHA-III
  • 8-iso Prostaglandin F2α MaxSpec Standard
  • Prosta-5,13-dien-1-oic acid, 9,11,15-trihydroxy-, (5Z,8β,9α,11α,13E,15S)-
  • 8-iso Prostaglandin F2α MaxSpec? Standard
  • Dinoprost Trometamol EP Impurity C
  • 8-iso Prostaglandin F2α
  • 8-epi-Prostaglandin F2α
  • (Z)-7-[(1S,2R,3R,5S)-3,5-dihydroxy-2-[(E)-(3S)-3-hydroxyoct-1-enyl]cyclopentyl]hept-5-enoic acid ((8S)-PGF2α
  • Prosta-5,13-dien-1-oic acid, 9,11,15-trihydroxy-, (5Z,8β,9α,11α,13E,15S)-
  • 27415-26-5
  • Intermediates & Fine Chemicals
  • Pharmaceuticals
  • Chiral Reagents