11BETA-PROSTAGLANDIN E1 Property

Boiling point:

531.0±50.0 °C(Predicted)

Density 

1.153±0.06 g/cm3(Predicted)

storage temp. 

Store at -20°C

solubility 

DMF: >100 mg/ml; DMSO: >100 mg/ml; Ethanol: >100 mg/ml; PBS pH 7.2: 3 mg/ml

form 

A crystalline solid

pka

4.76±0.10(Predicted)

Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Danger

Hazard statements

H302Harmful if swallowed

H360May damage fertility or the unborn child

Precautionary statements

P201Obtain special instructions before use.

P202Do not handle until all safety precautions have been read and understood.

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P270Do not eat, drink or smoke when using this product.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P301+P312IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.

P308+P313IF exposed or concerned: Get medical advice/attention.

P330Rinse mouth.

P405Store locked up.

P501Dispose of contents/container to..…

11BETA-PROSTAGLANDIN E1 Chemical Properties,Usage,Production

Description

8-iso PGF_2α is an isoprostane produced by the non-enzymatic peroxidation of arachidonic acid in membrane phospholipids. It is present in human plasma in two distinct forms - esterified in phospholipids and as the free acid. The ratio of these two forms is approximately 2:1, with a total plasma 8-iso PGF_2α level of about 150 pg/ml in normal volunteers. In normal human urine, 8-iso PGF_2α levels are about 180-200 pg/mg of creatinine. 8-iso PGF_2α is a weak TP receptor agonist in vascular smooth muscle. Conversely, 8-iso PGF_2α inhibits platelet aggregation induced by U-46619 (10⁻⁶ M) and I-BOP (3 x 10⁻⁷ M) with IC₅₀ values of 1.6 x 10⁻⁶ M and 1.8 x 10⁻⁶ M, respectively.

Description

8-iso Prostaglandin F_2α (8-iso PGF_2α) is an isoprostane produced by the non-enzymatic peroxidation of arachidonic acid in membrane phospholipids. It is present in human plasma in two distinct forms - esterified in phospholipids and as the free acid. The ratio of these two forms is approximately 2:1, with a total plasma 8-iso PGF_2α level of about 150 pg/ml in normal volunteers. In normal human urine, 8-iso PGF_2α levels are about 180-200 pg/mg of creatinine. 8-iso PGF_2α is a weak TP receptor agonist in vascular smooth muscle. Conversely, 8-iso PGF_2α inhibits platelet aggregation induced by U-46619 (10⁻⁶ M) and I-BOP (3 x 10⁻⁷ M) with IC₅₀ values of 1.6 x 10⁻⁶ M and 1.8 x 10⁻⁶ M, respectively.

8-iso Prostaglandin F_2α MaxSpec^® standard is a quantitative grade standard of 8-iso Prostaglandin F_2α that has been prepared specifically for mass spectrometry and related applications where quantitative reproducibility is required. The solution has been prepared gravimetrically and is supplied in a deactivated glass ampule sealed under argon. The concentration was verified by comparison to an independently prepared calibration standard. This 8-iso Prostaglandin F_2α MaxSpec^® standard is guaranteed to meet identity, purity, stability, and concentration specifications and is provided with a batch-specific certificate of analysis. Ongoing stability testing is performed to ensure the concentration remains accurate throughout the shelf life of the product. Note: The amount of solution added to the vial is in excess of the listed amount. Therefore, it is necessary to accurately measure volumes for preparation of calibration standards. Follow recommended storage and handling conditions to maintain product quality.

Uses

(8-epi-prostaglandin F2a) A major metabolite of PGF2α. A prostaglandin derivative used as a biomarker in the diagnosis and treatment of cardiovascular-related diseases as well as biomarkers of total body oxidative stress.

Uses

A major metabolite of PGF2α. A prostaglandin derivative used as a biomarker in the diagnosis and treatment of cardiovascular-related diseases as well as biomarkers of total body oxidative stress.

Definition

ChEBI: A prostanoid that is prostaglandin F2alpha having inverted stereochemistry at the 8-position.