ChemicalBook > CAS DataBase List > 5-CHLORO-1H-PYRROLO[3,2-B] PYRIDINE

5-CHLORO-1H-PYRROLO[3,2-B] PYRIDINE

Product Name
5-CHLORO-1H-PYRROLO[3,2-B] PYRIDINE
CAS No.
65156-94-7
Chemical Name
5-CHLORO-1H-PYRROLO[3,2-B] PYRIDINE
Synonyms
5-Chloro-4-azaindole;5-cChloro-1H-pyrrolo[3,2-b]pyridine;5-CHLORO-1H-PYRROLO[3,2-B] PYRIDINE;1H-Pyrrolo[3,2-b]pyridine, 5-chloro-;5-Chloro-4-azaindole,5-chloro-1H-pyrrolo[3,2-b]pyridine
CBNumber
CB7704671
Molecular Formula
C7H5ClN2
Formula Weight
152.58
MOL File
65156-94-7.mol
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5-CHLORO-1H-PYRROLO[3,2-B] PYRIDINE Property

Boiling point:
304.9±22.0 °C(Predicted)
Density 
1.425±0.06 g/cm3(Predicted)
storage temp. 
Keep in dark place,Sealed in dry,Room Temperature
form 
solid
pka
13.75±0.40(Predicted)
Appearance
Light brown to yellow Solid
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Safety

Hazard Codes 
Xi
WGK Germany 
3
HazardClass 
IRRITANT
HS Code 
2933998090
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Danger
Hazard statements

H302Harmful if swallowed

H318Causes serious eye damage

Precautionary statements

P280Wear protective gloves/protective clothing/eye protection/face protection.

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N-Bromosuccinimide Price

Sigma-Aldrich
Product number
ADE000995
Product name
5-Chloro-1H-pyrrolo[3,2-b]pyridine
Purity
Aldrich
Packaging
1g
Price
$427
Updated
2025/07/31
TRC
Product number
B418638
Product name
5-cChloro-1H-pyrrolo[3,2-b]pyridine
Packaging
50mg
Price
$45
Updated
2021/12/16
Biosynth Carbosynth
Product number
FC38532
Product name
5-Chloro-1H-pyrrolo[3,2-b]pyridine
Packaging
250mg
Price
$100
Updated
2021/12/16
Biosynth Carbosynth
Product number
FC38532
Product name
5-Chloro-1H-pyrrolo[3,2-b]pyridine
Packaging
500mg
Price
$160
Updated
2021/12/16
AK Scientific
Product number
A971
Product name
5-Chloro-1H-pyrrolo[3,2-b]pyridine
Packaging
1g
Price
$189
Updated
2021/12/16
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5-CHLORO-1H-PYRROLO[3,2-B] PYRIDINE Chemical Properties,Usage,Production

Uses

5-Chloro-1H-pyrrolo[3,2-B]pyridine can be used as an organic synthesis intermediate and a pharmaceutical intermediate, and is mainly used in laboratory research and development processes and chemical pharmaceutical production processes.

Synthesis

1420070-26-3

65156-94-7

General procedure for the synthesis of 5-chloro-1H-pyrrolo[3,2-B]pyridine from compound (CAS:1420070-26-3): 5-chloro-1H-pyrrolo[3,2-B]pyridine (1.01 g, 5.1 mmol) was dissolved in 20 mL of methanol. 1 mL of concentrated hydrochloric acid was added and the reaction mixture was stirred at 75 °C for 21 hours. After completion of the reaction, the solvent was removed by evaporation under reduced pressure and the residue was extracted by partitioning with saturated potassium carbonate solution and ethyl acetate. The organic layer was dried with anhydrous magnesium sulfate, filtered and concentrated under reduced pressure. Purification by fast column chromatography (eluent: ethyl acetate/hexane, 33:67, v/v) afforded 0.55 g (3.6 mmol, 71% yield) of the target product, 5-chloro-1H-pyrrolo[3,2-B]pyridine, as a light yellow solid with 95% purity.1H NMR (300 MHz, CDCl3 + DMSO-d6) δ 9.85 (br. s , 1H), 7.67 (d, J = 8.5 Hz, 1H), 7.47 (m, 1H), 7.10 (d, J = 8.5 Hz, 1H), 6.65 (m, 1H).HPLC/MS analysis (run time 9 min) showed a retention time of 4.27 min. Low resolution mass spectrometry (LRMS): m/z 153 ([M + H]+).

References

[1] Patent: EP2548876, 2013, A1. Location in patent: Paragraph 0283-0286
[2] Patent: WO2013/10880, 2013, A1. Location in patent: Page/Page column 83

5-CHLORO-1H-PYRROLO[3,2-B] PYRIDINE Preparation Products And Raw materials

Raw materials

Preparation Products

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5-CHLORO-1H-PYRROLO[3,2-B] PYRIDINE Suppliers

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View Lastest Price from 5-CHLORO-1H-PYRROLO[3,2-B] PYRIDINE manufacturers

Zhuozhou Wenxi import and Export Co., Ltd
Product
5-CHLORO-1H-PYRROLO[3,2-B] PYRIDINE 65156-94-7
Price
US $15.00-10.00/KG
Min. Order
1KG
Purity
99%+ HPLC
Supply Ability
Monthly supply of 1 ton
Release date
2021-07-10
Zhuozhou Wenxi import and Export Co., Ltd
Product
5-CHLORO-1H-PYRROLO[3,2-B] PYRIDINE 65156-94-7
Price
US $15.00-10.00/KG
Min. Order
1KG
Purity
99%+ HPLC
Supply Ability
Monthly supply of 1 ton
Release date
2021-07-09
Career Henan Chemical Co
Product
5-CHLORO-1H-PYRROLO[3,2-B] PYRIDINE 65156-94-7
Price
US $9.80/KG
Min. Order
1g
Purity
≥99%
Supply Ability
100kg
Release date
2020-01-10

65156-94-7, 5-CHLORO-1H-PYRROLO[3,2-B] PYRIDINERelated Search:

ethyl 5-chloro-1H-pyrrolo[3,2-b]pyridine-2-carboxylate 6-Chloro-1,3-dihydro-2H-pyrrolo[3,2-c]pyridin-2-one 1H-Pyrrolo[2,3-b]pyridine-3-carbonitrile, 5-chloro- 5-CHLORO (1H)INDAZOLE 5-chloro-1,2,3,4-tetrahydro-1,6-naphthyridine 5-Chloro-6-azaindole-3-carboxaldehyde 5-Chloro-1H-pyrazolo[4,3-b]pyridine 5-Chloro-1,2,3,4-tetrahydroisoquinoline 5-CHLORO-1H-PYRAZOLO[3,4-C]PYRIDINE 5-Chloro-[1,2,4]triazolo[1,5-a]pyridine 5-CHLORO-3-HYDROXY (1H)INDAZOLE 5-CHLORO-1H-INDOL-3-METHYLAMINE 5-Chloro-1H-pyrrolo[2,3-b]pyridine-3-carboxylic acid 5-Chloro-1,3,4-thiadiazol-2-ylamine 6-Chloro-3H-1,2,3-triazolo[4,5-c]pyridine 5-CHLORO-1H-PYRROLO[2,3-C]PYRIDINE 5-Chloro-7-azaindole-3-carboxaldehyde 5-Chloro-7-azaindole-3-carboxylic acid Methyl ester

  • 5-Chloro-4-azaindole,5-chloro-1H-pyrrolo[3,2-b]pyridine
  • 1H-Pyrrolo[3,2-b]pyridine, 5-chloro-
  • 5-CHLORO-1H-PYRROLO[3,2-B] PYRIDINE
  • 5-Chloro-4-azaindole
  • 5-cChloro-1H-pyrrolo[3,2-b]pyridine
  • 65156-94-7
  • Azaindoles