SNC 80

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Product Name: SNC 80
CAS No.: 156727-74-1
Chemical Name: SNC 80
Synonyms: SNC 80;NIH 10815;SNC80, delta opioid receptor agonist;(+)-4-[(Ar)-alpha-((2s,5r)-4-allyl-2,5-dimethyl-1-piperazinyl)-3;4-(alpha-(4-allyl-2,5-dimethyl-1-piperazinyl)-3-methoxybenzyl)-N,N-diethylbenzamide;(+)-4-[(AR)-A-((2S,5R)-4-ALLYL-2,5-DIMETHYL-1-PIPERAZINYL)-3-METHOXYBENZYL]-N,N-DIETHYLBENZAM;(+)-4-[(aR)-α-((2S,5R)-4-Allyl-2,5-dimethyl-1-piperazinyl)-3-methoxybenzyl]-N,N-diethylbenzamide;(+)-4-[(AR)-A-((2S,5R)-4-ALLYL-2,5-DIMETHYL-1-PIPERAZINYL)-3-METHOXYBENZYL]-N,N-DIETHYLBENZAMIDE;(+)-4-[(αr)-α-((2s,5r)-4-allyl-2,5-dimethyl-1-piperazinyl)-3-methoxybenzyl]-n,n-diethylbenzamide;(+)-4-[(AR)-ALPHA-((2S,5R)-4-ALLYL-2,5-DIMETHYL-1-PIPERAZINYL)-3-METHOXYBENZYL]-N,N-DIETHYLBENZAMIDE
CBNumber: CB7712786
Molecular Formula: C28H39N3O2
Formula Weight: 449.63
MOL File: 156727-74-1.mol

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SNC 80 Property

Melting point:: 122-123°C
Boiling point:: 564.8±50.0 °C(Predicted)
Density: 1.040
storage temp.: Store at RT
solubility: DMSO: soluble
form: solid
pka: 7.29±0.10(Predicted)
color: off-white
Stability:: Store in Freezer
InChI: InChI=1S/C28H39N3O2/c1-7-17-30-19-22(5)31(20-21(30)4)27(25-11-10-12-26(18-25)33-6)23-13-15-24(16-14-23)28(32)29(8-2)9-3/h7,10-16,18,21-22,27H,1,8-9,17,19-20H2,2-6H3/t21-,22+,27-/m1/s1
InChIKey: KQWVAUSXZDRQPZ-UMTXDNHDSA-N
SMILES: C(N(CC)CC)(=O)C1=CC=C([C@@H](N2C[C@@H](C)N(CC=C)C[C@@H]2C)C2=CC=CC(OC)=C2)C=C1

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Safety

WGK Germany: 3

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Hazard and Precautionary Statements (GHS)

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N-Bromosuccinimide Price

Sigma-Aldrich

Product number: S2812
Product name: SNC80
Purity: ≥98% (HPLC), solid
Packaging: 5mg
Price: $459
Updated: 2024/03/01

Sigma-Aldrich

Product number: S2812
Product name: SNC80
Purity: ≥98% (HPLC), solid
Packaging: 25mg
Price: $1650
Updated: 2024/03/01

Sigma-Aldrich

Product number: 5.08161
Product name: SNC80 - CAS 156727-74-1 - Calbiochem
Packaging: 10mg
Price: $299
Updated: 2024/03/01

Cayman Chemical

Product number: 15599
Product name: SNC 80
Purity: ≥99%
Packaging: 5mg
Price: $68
Updated: 2024/03/01

Cayman Chemical

Product number: 15599
Product name: SNC 80
Purity: ≥99%
Packaging: 25mg
Price: $286
Updated: 2024/03/01

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SNC 80 Chemical Properties,Usage,Production

Description

SNC 80 is a selective nonpeptide agonist of the δ-opioid receptor (K_i = 0.18 nM, IC₅₀ = 2.73 nM) that is over 2,000-fold less effective at the μ-opioid receptor. It effectively activates μ/δ receptor heteromers (EC₅₀ = 52.8 nM) but not κ/δ or μ/κ heteromers. SNC 80 has antinociceptive as well as pro-convulsant effects in vivo.

Chemical Properties

Crystalline Solid

Uses

A highly selective and potent non-peptide -agonist, 2000-fold selective over u-receptors

Uses

Rats were administered SNC80 to study the role of nitric oxide synthase in peripheral antinociception mechanism.⁵

Definition

ChEBI: 4-[(R)-[(2S,5R)-2,5-dimethyl-4-prop-2-enyl-1-piperazinyl]-(3-methoxyphenyl)methyl]-N,N-diethylbenzamide is a diarylmethane.

Biological Activity

A highly selective and potent non-peptide δ -opioid agonist, 2000-fold selective over μ -opioid receptors.

Biochem/physiol Actions

SNC80 is a highly selective agonist of δ opioid receptor but also binds to μ-δ opioid receptor heteromers to produce antinociception in mice.2 It also acts as anti-depressant3, elicits dopamine-related behaviors and enhances behavioral responses to psychostimulants.4

storage

Store at RT

SNC 80 Preparation Products And Raw materials

Raw materials

Preparation Products

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156727-74-1, SNC 80Related Search:

1-(4-METHYLBENZYL)PIPERAZINE 2-Aminoethyldiisopropylamine (R)-(-)-2-Methylpiperazine 4-[(4-METHYLPIPERAZIN-1-YL)METHYL]BENZALDEHYDE 3-Methyl-1-benzyl-piperazine trans-2,5-Dimethylpiperazine [4-[(4-METHYLPIPERAZIN-1-YL)METHYL]PHENYL]METHYLAMINE N-1-Benzyl-2-methylpiperazine N,N-DIETHYLBENZAMIDE (S)-1-ISOPROPYL-2-METHYL-PIPERAZINE 4-[(S)-[(2S,5R)-2,5-DIMETHYL-4-(2-PROPENYL)-1-PIPERAZINYL]PHENYLMETHYL]-N,N-DIETHYLBENZAMIDE (2S,5R)-1-BENZYL-2,5-DIMETHYLPIPERAZINE N-[4-(AMINOMETHYL)BENZYL]-N,N-DIETHYLAMINE SNC 80 1-(3-METHOXYBENZYL)PIPERAZINE [(4-METHYLPHENYL)PHENYLMETHYL]PIPERAZINE Aligeron CHEMBRDG-BB 4015543

4-[(R)-[(2S,5R)-2,5-Dimethyl-4-(2-propen-1-yl)-1-piperazinyl](3-methoxyphenyl)methyl]-N,N-diethylbenzamide

(+)-4-[(Ar)-alpha-((2s,5r)-4-allyl-2,5-dimethyl-1-piperazinyl)-3

NIH 10815

(+)-4-[(AR)-A-((2S,5R)-4-ALLYL-2,5-DIMETHYL-1-PIPERAZINYL)-3-METHOXYBENZYL]-N,N-DIETHYLBENZAM

(+)-4-[(AR)-A-((2S,5R)-4-ALLYL-2,5-DIMETHYL-1-PIPERAZINYL)-3-METHOXYBENZYL]-N,N-DIETHYLBENZAMIDE

(+)-4-[(AR)-ALPHA-((2S,5R)-4-ALLYL-2,5-DIMETHYL-1-PIPERAZINYL)-3-METHOXYBENZYL]-N,N-DIETHYLBENZAMIDE

SNC 80

(+)-4-[(αr)-α-((2s,5r)-4-allyl-2,5-dimethyl-1-piperazinyl)-3-methoxybenzyl]-n,n-diethylbenzamide

4-(alpha-(4-allyl-2,5-dimethyl-1-piperazinyl)-3-methoxybenzyl)-N,N-diethylbenzamide

(+)-4-[(aR)-α-((2S,5R)-4-Allyl-2,5-dimethyl-1-piperazinyl)-3-methoxybenzyl]-N,N-diethylbenzamide

(+)-4-[(alphaR)-alpha-((2S,5R)-4-Allyl-2,5-dimethyl-1-piperazinyl)-3-methoxybenzyl]-N,N-diethylbenzamide

Benzamide, 4-[(R)-[(2S,5R)-2,5-dimethyl-4-(2-propen-1-yl)-1-piperazinyl](3-methoxyphenyl)methyl]-N,N-diethyl-

SNC80, delta opioid receptor agonist

156727-74-1

C28H39N3O2

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Chiral Reagents

Opioid receptor and opioid-like receptor