(R)-(-)-2-Methylpiperazine

Product Name: (R)-(-)-2-Methylpiperazine
CAS No.: 75336-86-6
Chemical Name: (R)-(-)-2-Methylpiperazine
Synonyms: R-MP;NNX3;URI1;C19orf2;PPP1R19;(R)-2-methylpiperadine;(R)-2-METHYLPIPERAZINE;(2R)-2-Methylpiperazine;Phenylephrine Impurity 84;(R)-(-)-2-METHYLPIPERAZINE
CBNumber: CB9445086
Molecular Formula: C5H12N2
Formula Weight: 100.16
MOL File: 75336-86-6.mol

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(R)-(-)-2-Methylpiperazine Property

Melting point:: 91-93 °C (lit.)
Boiling point:: 155-156 °C
alpha: -18 º (c=1, toluene)
Density: 0.9305 (estimate)
refractive index: 1.4378 (estimate)
Flash point:: 149 °F
storage temp.: Keep in dark place,Inert atmosphere,Room temperature
pka: 9.31±0.40(Predicted)
form: Crystalline Powder, Crystals and/or Chunks
color: White to yellow
optical activity: [α]20/D 16.5°, c = 5 in benzene
Water Solubility: soluble
Sensitive: Air Sensitive & Hygroscopic
BRN: 3647994
CAS DataBase Reference: 75336-86-6(CAS DataBase Reference)

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Safety

Hazard Codes: F,C,Xi
Risk Statements: 11-36/37/38-34
Safety Statements: 16-26-36/37/39-45-36
RIDADR: UN 1325 4.1/PG 2
WGK Germany: 2
HazardClass: 4.1
PackingGroup: III
HS Code: 29335990

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Danger

Hazard statements

H228Flammable solid

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P210Keep away from heat/sparks/open flames/hot surfaces. — No smoking.

P302+P352IF ON SKIN: wash with plenty of soap and water.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

Sigma-Aldrich

Product number: 397164
Product name: (R)-(?)-2-Methylpiperazine
Purity: 97%
Packaging: 1g
Price: $37.54
Updated: 2025/07/31

Sigma-Aldrich

Product number: SAB1305286
Product name: ANTI-RMP (URI)(C-TERMINAL) antibody produced in rabbit
Purity: IgG fraction of antiserum, buffered aqueous solution
Packaging: 400μL
Price: $461
Updated: 2023/01/07

TCI Chemical

Product number: M2091
Product name: (R)-(-)-2-Methylpiperazine
Purity: >98.0%(GC)(T)
Packaging: 5g
Price: $116
Updated: 2025/07/31

TCI Chemical

Product number: M2091
Product name: (R)-(-)-2-Methylpiperazine
Purity: >98.0%(GC)(T)
Packaging: 25g
Price: $368
Updated: 2025/07/31

TRC

Product number: M725643
Product name: (R)-(-)-2-Methylpiperazine
Packaging: 50mg
Price: $45
Updated: 2021/12/16

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(R)-(-)-2-Methylpiperazine Chemical Properties,Usage,Production

Chemical Properties

white to light yellow crystalline powder

Uses

Valuable synthon for quinoline antibacterials.

Synthesis

126458-16-0

75336-86-6

General procedure for the synthesis of (R)-(-)-2-methylpiperazine L-tartrate from (R)-2-methylpiperazine L-tartrate: (R)-2-methylpiperazine L-tartrate (from Example 4) was dissolved in water (182 L) and branched octane (200 L), added to a 4,000 L reactor and stirred until completely dissolved. Subsequently, more branched octane (530 L) was added to the reactor and a 50% sodium hydroxide solution (1120 kg) was slowly added over a temperature range of 35°C to 52°C. The reaction mixture was heated to 80 °C with continuous stirring for 2 h. The lower aqueous phase was then separated and transferred to a 4000 L receiver. The organic phase in the reactor was cooled to 21°C, filtered through a 48-inch Nutsche filter, and the filtrate was transferred to a 1200L reactor. The 4000L reactor and filter were rinsed with branched octane (300L). The solid product was dried over nitrogen at 25 °C to give a final 24.9 kg (67% yield) of (R)-(-)-2-methylpiperazine with an optical purity of not less than 99% ee (as determined by chiral HPLC). The pH of the aqueous phase in the receiver was adjusted to 8.4 with acetic acid (812 kg) prior to treatment.The overall yield of (R)-(-)-2-methylpiperazine was 42% starting from (R)-2-methylpiperazine L-tartrate. The melting point of the product was 91-93 °C.1H NMR (400 MHz, CDCl3) δ: 2.97-2.68 (6H, m), 2.35 (1H, dd, J = 11.7, 10.2 Hz), 1.61 (2H, s), 1.00 (3H, d, J = 6.7 Hz), 0.00 (TMS, ref).13C NMR ( 100MHz, CDCl3) δ: 54.14(t), 51.89(d), 47.43(t), 46.46(t), 20.08(q), 0.00 (TMS, ref.) IR (mineral oil paste) νmax: 3220(s, br), 2819(s), 2748, 2042(w), 1995(w), 1981(w), 1328, 1328(s, d, J = 6.7Hz), 0.00 (TMS, ref.). (w), 1328, 1279, 1137, 1094, 960, 859(s), 845(s), 795(s), 621(s) cm-1. HRMS (FAB) calculated value for C5H12N2 [M+H]+: 101.1079, measured value: 101.1080. [α]25D = -17° (c 0.85, CH2Cl2). Elemental analysis calculated values for C5H12N2: C, 59.96; H, 12.07; N, 27.97. measured values: C, 59.25; H, 11.71; N, 27.64.

References

[1] Patent: WO2004/829, 2003, A1. Location in patent: Page 25-26

(R)-(-)-2-Methylpiperazine Preparation Products And Raw materials

Raw materials

Preparation Products

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(R)-(-)-2-Methylpiperazine Suppliers

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View Lastest Price from (R)-(-)-2-Methylpiperazine manufacturers

Shenzhen Nexcon Pharmatechs Ltd.

Product: (R)-(-)-2-Methylpiperazine 75336-86-6
Price: US $0.00-0.00/KG
Min. Order: 1KG
Purity: 99%
Supply Ability: 2000
Release date: 2025-06-10

Hebei Ganmiao New material Technology Co., LTD

Product: (R)-(-)-2-Methylpiperazine 75336-86-6
Price: US $10.00-7.00/kg
Min. Order: 1kg
Purity: 98%
Supply Ability: 20ton
Release date: 2024-06-06

Hebei Zhanyao Biotechnology Co. Ltd

Product: R)-(-)-2-Methylpiperazine 75336-86-6
Price: US $10.00/KG
Min. Order: 1KG
Purity: 99%
Supply Ability: 20 Tons
Release date: 2021-10-14

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(R)-(-)-2-METHYLPIPERAZINE

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R-(-)-2-Methylpiperazine100.15

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(R)-2-methylpiperadine

(2R)-2-Methylpiperazine

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ANTI-RMP (URI)(C-TERMINAL) antibody produced in rabbit

C19orf2

NNX3

PPP1R19

URI1

(R)-(-)-2-Methylpiperazine 97%

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(R)-(-)-2-Methylpiperazine&gt

(R)-(-)-2-Methylpiperazine ISO 9001：2015 REACH

(R)-(-)-2-Methylpiperazine 75336-86-6

Phenylephrine Impurity 84

75336-86-6

Piperazines

Heterocyclic Building Blocks

Asymmetric Synthesis

Chiral Building Blocks

Heterocyclic Building Blocks

Piperaizine

Piperazines

Chiral Compounds