METHYL OROTATE
Uses- Product Name
- METHYL OROTATE
- CAS No.
- 6153-44-2
- Chemical Name
- METHYL OROTATE
- Synonyms
- NSC 42009;METHYL OROTATE;Methyl orothate.;Methyl orotate,99%;RARECHEM AL BF 1310;6-Methylcarboxyuracil;6-Carbomethyoxyuracil;OROTIC ACID METHYL ESTER;Methyl orotate, 99% 25GR;6153-44-2 METHYL OROTATE
- CBNumber
- CB7722527
- Molecular Formula
- C6H6N2O4
- Formula Weight
- 170.12
- MOL File
- 6153-44-2.mol
METHYL OROTATE Property
- Melting point:
- 244 °C
- Boiling point:
- 299.73°C (rough estimate)
- Density
- 1.5523 (rough estimate)
- refractive index
- 1.5100 (estimate)
- storage temp.
- Sealed in dry,Room Temperature
- form
- Powder
- pka
- 5.42±0.10(Predicted)
- color
- Off-white to yellow or light brown
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H302Harmful if swallowed
H315Causes skin irritation
H319Causes serious eye irritation
H335May cause respiratory irritation
- Precautionary statements
-
P261Avoid breathing dust/fume/gas/mist/vapours/spray.
P280Wear protective gloves/protective clothing/eye protection/face protection.
P301+P312IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.
P302+P352IF ON SKIN: wash with plenty of soap and water.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
N-Bromosuccinimide Price
- Product number
- M320990
- Product name
- MethylOrotate
- Packaging
- 10g
- Price
- $195
- Updated
- 2021/12/16
- Product number
- 4H48-1-2F
- Product name
- Methyl 2,6-dioxo-1,2,3,6-tetrahydropyrimidine-4-carboxylate
- Packaging
- 1g
- Price
- $45
- Updated
- 2021/12/16
- Product number
- 079377
- Product name
- Methyl 2,6-dioxo-1,2,3,6-tetrahydropyrimidine-4-carboxylate
- Packaging
- 5g
- Price
- $60
- Updated
- 2021/12/16
- Product number
- 4H48-1-2F
- Product name
- Methyl 2,6-dioxo-1,2,3,6-tetrahydropyrimidine-4-carboxylate
- Packaging
- 25g
- Price
- $495
- Updated
- 2021/12/16
- Product number
- W7377
- Product name
- Methylorotate
- Packaging
- 100g
- Price
- $523
- Updated
- 2021/12/16
METHYL OROTATE Chemical Properties,Usage,Production
Uses
Methyl Orotate is used in the synthesis of pyrrimidine hydrazine acids used in peptide recognition. Also used in the preparation of pyrimidines bearing an acyclic moiety.
Chemical Properties
yellow to light brown crystalline powder
Uses
Methyl Orotate is used in the synthesis of pyrrimidine hydrazine acids used in peptide recognition. Also used in the preparation of pyrimidines bearing an acyclic moiety.
Synthesis
67-56-1
65-86-1
6153-44-2
To a 500 mL three-necked flask was added whey acid (15.6 g, 0.10 mol), followed by 300 mL of anhydrous methanol, stirring and cooling the reaction system to 0°C. Thionyl chloride (10.9 mL, 0.15 mol) was added dropwise, slowly, while maintaining the temperature at 0-5°C. The reaction system was then cooled to 0°C. The reaction system was then cooled to 0°C. The reaction system was then cooled to 0°C. After the dropwise addition, the reaction system was warmed up to reflux and the reaction was continued for 6 hours. Upon completion of the reaction, the reaction mixture was slightly cooled and subsequently dried under vacuum to remove the solvent. To the residue, 50 mL of anhydrous methanol was added and removed with thorough stirring. Next, 150 mL of methyl tert-butyl ether was added and stirred at room temperature for 1 hour. Finally, the solid product was collected by filtration and washed with methyl tert-butyl ether to afford 15.8 g of the target compound, methyl 2,6-dioxo-1,2,3,6-tetrahydropyrimidine-4-carboxylate, in 92.9% yield.
References
[1] Patent: CN106831607, 2017, A. Location in patent: Paragraph 0047
[2] Canadian Journal of Chemistry, 2005, vol. 83, # 10, p. 1731 - 1740
[3] Nucleosides, Nucleotides and Nucleic Acids, 2005, vol. 24, # 5-7, p. 1123 - 1126
[4] Chemische Berichte, 1930, vol. 63, p. 1000
[5] Journal of the American Chemical Society, 1947, vol. 69, p. 675
METHYL OROTATE Preparation Products And Raw materials
Raw materials
Preparation Products
METHYL OROTATE Suppliers
- Tel
- +49 3493/605464
- Fax
- +49 3493/605470
- sales@intatrade.de
- Country
- Germany
- ProdList
- 3572
- Advantage
- 66
- Tel
- --
- Fax
- --
- info@abcr.de
- Country
- Germany
- ProdList
- 6831
- Advantage
- 75
- Tel
- --
- Fax
- --
- sales@rarechem.de
- Country
- Germany
- ProdList
- 6297
- Advantage
- 38
View Lastest Price from METHYL OROTATE manufacturers
- Product
- METHYL OROTATE 6153-44-2
- Price
- US $2000.00-1650.00/KG
- Min. Order
- 1G
- Purity
- 98%
- Supply Ability
- 100kg
- Release date
- 2018-08-03