Chemical Properties Content Analysis Uses Production Method Toxicity
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Isopropyl myristate

Chemical Properties Content Analysis Uses Production Method Toxicity
Product Name
Isopropyl myristate
CAS No.
110-27-0
Chemical Name
Isopropyl myristate
Synonyms
IPM;1-Methylethyl tetradecanoate;MYRISTIC ACID ISOPROPYL ESTER;IPM 100;BISOMEL;Propyl myristate;sopropyl myristate;ISOPROPYL TETRADECANOATE;ISO-PROPYL N-TETRADECANOATE;MYRISTIC ACID ISOPROPYL ESTER MINIMU
CBNumber
CB9482638
Molecular Formula
C17H34O2
Formula Weight
270.45
MOL File
110-27-0.mol
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Isopropyl myristate Property

Melting point:
~3 °C (lit.)
Boiling point:
193 °C/20 mmHg (lit.)
Density 
0.85 g/mL at 25 °C (lit.)
vapor pressure 
<1 hPa (20 °C)
refractive index 
n20/D 1.434(lit.)
FEMA 
3556 | ISOPROPYL MYRISTATE
Flash point:
>230 °F
storage temp. 
2-8°C
solubility 
<0.05mg/l
form 
Liquid
Specific Gravity
0.855 (20/4℃)
color 
Clear
Odor
odorless
Water Solubility 
Miscible with alcohol. Immiscible with water and glycerol.
Merck 
14,5215
JECFA Number
311
BRN 
1781127
Stability:
Stable. Combustible. Incompatible with strong oxidizing agents.
InChIKey
AXISYYRBXTVTFY-UHFFFAOYSA-N
LogP
7.71
CAS DataBase Reference
110-27-0(CAS DataBase Reference)
NIST Chemistry Reference
Isopropyl Myristate(110-27-0)
EPA Substance Registry System
Isopropyl myristate (110-27-0)
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Safety

Hazard Codes 
Xi
Risk Statements 
36/37/38
Safety Statements 
26-36
WGK Germany 
-
RTECS 
XB8600000
Autoignition Temperature
>300 °C
TSCA 
Yes
HS Code 
29159080
Hazardous Substances Data
110-27-0(Hazardous Substances Data)
Toxicity
LD50 orally in Rabbit: > 10000 mg/kg LD50 dermal Rabbit > 5000 mg/kg
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H315Causes skin irritation

Precautionary statements

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P321Specific treatment (see … on this label).

P332+P313IF SKIN irritation occurs: Get medical advice/attention.

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N-Bromosuccinimide Price

Sigma-Aldrich
Product number
W355690
Product name
Isopropyl Myristate
Purity
≥98%
Packaging
1kg
Price
$112
Updated
2024/03/01
Sigma-Aldrich
Product number
W355690
Product name
Isopropyl Myristate
Purity
≥98%
Packaging
8kg
Price
$421
Updated
2024/03/01
Sigma-Aldrich
Product number
W355690
Product name
Isopropyl Myristate
Purity
≥98%
Packaging
20kg
Price
$983
Updated
2024/03/01
Sigma-Aldrich
Product number
8.22102
Product name
Isopropyl myristate
Purity
for synthesis
Packaging
100mL
Price
$41.4
Updated
2024/03/01
Sigma-Aldrich
Product number
8.22102
Product name
Isopropyl myristate
Purity
for synthesis
Packaging
1L
Price
$151
Updated
2024/03/01
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Isopropyl myristate Chemical Properties,Usage,Production

Chemical Properties

Isopropyl myristate is a colorless and odorless liquid with a faint odor, and miscible with vegetable oil. It is not easy to be either hydrolyzed or become rancid. The refractive index nD20 is 1.435~1.438, and the relative density (20&deg;C) is 0.85~0.86. it is used in many applications, including pharma, food and personal care product manufacturing.

Content Analysis

Weight 1.5 g sample. Then it is determined by the method ester assay (OT-18). The equivalent factor (e) in the calculation is 135.2. Or it is determined by a non-polar column method of gas chromatography (GT-10-4).

Uses

Isopropyl myristate (IPM) is a fatty acid ester which is used as solvent in water-in-oil emulsion, oils and fatty based ointments. The use of IPM is recommended in the Sterility Test chapter of the European, Japanese and United States Pharmacopoeia (EP, 2.6.13, JP, 4.06 and USP, 71) as diluent for oils and oily solutions, as well as for ointments and creams. Indeed, its solvent properties improve the filterability of these samples.
Isopropyl myristate is known as a penetration enhancer for topical preparations. It is a waterclear, low viscous oily liquid with a very good spreading capacity on the skin. Isopropyl Myristate is mainly used in cosmetics as an oilcomponent for emulsions, bath oils and as a solvent for active substances.

Production Method

It is a product of esterification of myristic acid derived from re-steamed coconut coil with isopropyl alcohol.
(1)  200 kg myristic acid and 450 kg isopropyl alcohol were added into the reaction vessel in turn. After mixing, 360 kg sulfuric acid (98%) was added. The reaction mixture was heated to reflux for 10 hours. Isopropyl alcohol was then recovered, washed with ice water, and neutralized with Na2CO3 aqueous solution (10%). Under normal pressure, isopropyl alcohol and water were distilled. While under reduced pressure, isopropyl myristate was distilled (185°C/1.0kPa~195°C/2.7kPa).
(2) 90 kg isopropyl alcohol was added into the reaction vessel and then sulfuric acid as catalyst, with 5% of the total amount, was added. During mixing, 228 kg myristic acid was added slowly. The mixture was heated to reflux and water was continuously separated. Until no water was separated, the reaction temperature was reduced and probe was obtained to measure the acid value. When the acid value reached 1.5 mg KOH/g, the reaction was completed. Alkali was then added for neutralization. After the removal of water under reduced pressure, the pressure was further reduced for dealcoholization until the acid value was 0.05~1.0 mg KOH/g. The final product is then isopropyl myristate.

Toxicity

ADI is not regulated (FAO/WHO, 2001).

Description

Isopropyl myristate is odorless when pure. May be synthesized by conventional esterification of isopropanol with myristic acid.

Chemical Properties

Pure isopropyl myristate is virtually odorless, very slightly fatty, but not rancid

Chemical Properties

colourless liquid of low viscosity

Chemical Properties

Isopropyl myristate is a clear, colorless, practically odorless liquid of low viscosity that congeals at about 5°C. It consists of esters of propan-2-ol and saturated high molecular weight fatty acids, principally myristic acid.

Occurrence

Reported found in kumquat peel oil, papaya, starfruit, plum brandy, coriander seed and loquat

Uses

Isopropyl myristate is an emollient in cosmetic and pharmaceutical bases.

Uses

isopropyl myristate is an emollient, moisturizer, binder, and skin softener that also assists in product penetration. An ester of myristic acid, it is naturally occurring in coconut oil and nutmeg. Although isopropyl myristate is generally considered comedogenic, some ingredient manufacturers clearly specify non-comedogenicity on their data sheets.

Uses

In cosmetic and topical medicinal Preparations where good absorption through the skin is desired. A jellied isopropyl myristate was marketed as Estergel (Merck & Co.) .

Definition

ChEBI: Isopropyl tetradecanoate is a fatty acid ester.

Production Methods

Isopropyl myristate may be prepared either by the esterification of myristic acid with propan-2-ol or by the reaction of myristoyl chloride and propan-2-ol with the aid of a suitable dehydrochlorinating agent. A high-purity material is also commercially available, produced by enzymatic esterification at low temperature.

Preparation

By conventional esterification of isopropanol with myristic acid

brand name

Estergel (Merck).

General Description

Isopropyl myristate is an ester of isopropyl alcohol myristic acid. It is mainly used as a solubilizer, emulsifier and emollient in cosmetic and topical medicines. It also finds applications as a flavoring agent in the food industry.
Pharmaceutical secondary standards for application in quality control, provide pharma laboratories and manufacturers with a convenient and cost-effective alternative to the preparation of in-house working standards.

Pharmaceutical Applications

Isopropyl myristate is a nongreasy emollient that is absorbed readily by the skin. It is used as a component of semisolid bases and as a solvent for many substances applied topically. Applications in topical pharmaceutical and cosmetic formulations include bath oils; make-up; hair and nail care products; creams; lotions; lip products; shaving products; skin lubricants; deodorants; otic suspensions; and vaginal creams. For example, isopropyl myristate is a self-emulsifying component of a proposed cold cream formula, which is suitable for use as a vehicle for drugs or dermatological actives; it is also used cosmetically in stable mixtures of water and glycerol.
Isopropyl myristate is used as a penetration enhancer for transdermal formulations, and has been used in conjunction with therapeutic ultrasound and iontophoresis.It has been used in a water-oil gel prolonged-release emulsion and in various microemulsions. Such microemulsions may increase bioavailability in topical and transdermal applications. Isopropyl myristate has also been used in microspheres, and significantly increased the release of drug from etoposide-loaded microspheres.
Isopropyl myristate is used in soft adhesives for pressuresensitive adhesive tapes.

Contact allergens

Despite wide use in cosmetics, perfumes, and topical medicaments, isopropyl myristate is a very weak sen- sitizer and a mild irritant.

Biochem/physiol Actions

Isopropyl myristate (myristic acid isopropyl ester) is used to change the physicochemical characteristics of microsheres such as poly(lactic-co-glycolic acid) (PLGA) microspheres. Isopropyl myristate is used as a oil phase component in the formulaton of microemulsion systems.

Pharmacology

Isopropyl myristate is used in pharmaceutical preparations because it improves solubility and increases absorption through the skin. External uses include a non-irritating iodine preparation for disinfecting the skin (Powers & Rieger, 1963) and aerosol bactericidal preparations for feminine hygiene use without irritation of the skin and mucous membranes (Geistlich, 1970; Watson. 1969). Preparations for internal use include oral steroid formulations (Hirata, 1970) and anaesthetic injection solutions (Davis, Pearce & Connor, 1972).
Veterinary medications containing isopropyl myristate include oral or parenteral compositions for lungworm infections (N. V. Philips' Gloielampenfabrieken, 1964) and a spray formulation for bovine udders to treat mastitis, combat infection and improve the general skin condition (Kraus, 1965). Isopropyl myristate has been found to be an effective repository vehicle for im injection of penicillin in rabbits and for sc administration of oestrogens in ovariectomized rats (Platcow & Voss, 1954).
In assays on human forearms, vasoconstrictor activity of ointment preparations containing 0025% betamethasone 17-benzoate in white soft paraffin was increased by the presence of isopropyl myristate (Pepler, Woodford & Morrison, 1971). Donovan, Ohmart & Stoklosa (1954) noted that the good solvent properties of isopropyl myristate might increase the therapeutic activity of formulations by the apparent alteration in particle size of the active ingredients, so that further evaluation and clinical study would be necessary before its use in extemporaneous compounding could be recommended. Studies in which the antifungal activity of paraben esters solubilized by surfactants was decreased by isopropyl myristate (Matsumoto & Aoki, 1962) indicate that the effectiveness of medicinal substances may be influenced by the presence of surfactants and oily ingredients such as isopropyl myristate.

Side effects

Thrapecylate myristate is a medicine used to treat head lice infestations in adults and children 4 years of age and older. Common side effects include skin irritation, rash, and contact dermatitis.

Safety

Isopropyl myristate is widely used in cosmetics and topical pharmaceutical formulations, and is generally regarded as a nontoxic and nonirritant material.
LD50 (mouse, oral): 49.7 g/kg
LD50 (rabbit, skin): 5 g/kg

Synthesis

Isopropyl myristate is synthesized by conventional esterification of iso-Propanol with Myristic acid.

Metabolism

Higher molecular weight aliphatic esters are thought to be readily hydrolysed to the corresponding alcohols and acids which are then metabolized; isopropyl myristate is undoubtedly hydrolysed to normal metabolic products (Fassett, 1963). When myristic acid (as the ethyl ester) was fed to dogs,

storage

Isopropyl myristate is resistant to oxidation and hydrolysis, and does not become rancid. It should be stored in a well-closed container in a cool, dry place and protected from light.

Incompatibilities

When isopropyl myristate comes into contact with rubber, there is a drop in viscosity with concomitant swelling and partial dissolution of the rubber; contact with plastics, e.g. nylon and polyethylene, results in swelling. Isopropyl myristate is incompatible with hard paraffin, producing a granular mixture. It is also incompatible with strong oxidizing agents.

Regulatory Status

Included in the FDA Inactive Ingredients Database (otic, topical, transdermal, and vaginal preparations). Used in nonparenteral medicines licensed in the UK. Included in the Canadian List of Acceptable Non-medicinal Ingredients.

Isopropyl myristate Preparation Products And Raw materials

Raw materials

Preparation Products

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Isopropyl myristate Suppliers

Zhejiang Wumei Biotechnology Co., Ltd.
Tel
0579-88230027 13357031250
Email
17758082413@139.com
Country
China
ProdList
1
Advantage
58
Chengdu HuaXia Chemical Reagent Co. Ltd
Tel
400-1166-196 13458535857
Fax
QQ:800101999
Email
cdhxsj@163.com
Country
China
ProdList
13350
Advantage
58
Shanghai Aladdin Bio-Chem Technology Co.,LTD
Tel
400-400-6206333 18521732826
Fax
021-50323701
Email
market@aladdin-e.com
Country
China
ProdList
25003
Advantage
65
Hangzhou Jinghao Biotechnology Co., LTD
Tel
17513242016 17513242016
Fax
QQ:1576861551
Email
1576861551@qq.com
Country
China
ProdList
2800
Advantage
58
Tangyuan Life Science (Shanghai) Co., Ltd
Tel
400-618-1121 18616561988
Fax
400-618-1121
Email
sales@townyuan.com
Country
China
ProdList
3001
Advantage
58
Shanghai shengyue international trading co., ltd
Tel
021-66690837 13166269258
Email
2570384992@qq.com
Country
China
ProdList
46
Advantage
58
J & K SCIENTIFIC LTD.
Tel
010-82848833 400-666-7788
Fax
86-10-82849933
Email
jkinfo@jkchemical.com
Country
China
ProdList
96815
Advantage
76
Meryer (Shanghai) Chemical Technology Co., Ltd.
Tel
021-61259108 18621169109
Fax
86-21-61259102
Email
market03@meryer.com
Country
China
ProdList
40228
Advantage
62
future industrial shanghai co., ltd
Tel
400-0066400 13621662912
Fax
021-55660885
Email
sales@jonln.com
Country
China
ProdList
1995
Advantage
65
Alfa Aesar
Tel
400-6106006
Fax
021-67582001/03/05
Email
saleschina@alfa-asia.com
Country
China
ProdList
30123
Advantage
84
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View Lastest Price from Isopropyl myristate manufacturers

Hebei Zhuanglai Chemical Trading Co Ltd
Product
Isopropyl myristate 110-27-0
Price
US $55.00/kg
Min. Order
1kg
Purity
99%
Supply Ability
20 tons
Release date
2024-11-13
Yancheng Green Chemicals Co.,Ltd
Product
Isopropyl Myristate 110-27-0
Price
US $440.00/kg
Min. Order
175kg
Purity
99%
Supply Ability
10 ton
Release date
2023-11-15
Gansu Jinyuantai New Material Co., Ltd.
Product
Isopropyl myristate 110-27-0
Price
US $425.00/kg
Min. Order
175kg
Purity
≥98%
Supply Ability
10 tons
Release date
2023-11-15

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