HARMALOL HYDROCHLORIDE DIHYDRATE
- Product Name
- HARMALOL HYDROCHLORIDE DIHYDRATE
- CAS No.
- 6028-00-8
- Chemical Name
- HARMALOL HYDROCHLORIDE DIHYDRATE
- Synonyms
- HARMALOL HYDROCHLORID DIHYDRAT;ARMALOL HYDROCHLORIDE DIHYDRATE;HARMALOL HYDROCHLORIDE DIHYDRATE;HARMALOL HYDROCHLORIDE HYDRATE 98%;Harmalol hydrochloride hydrate,98%;Harmalol dihydrate hydrochloride;1-Methyl-4,9-dihydro-(3H)-beta-carbolin-7-olHCl;4,9-Dihydro-1-methyl-3H-pyrido[3,4-b]indol-7-ol;4,9-DIHYDRO-1-METHYL-3H-PYRIDO[3,4-B]INDOL-7-OL DIHYDRATE;1-METHYL-7-HYDROXY-3,4-DIHYDRO-BETA-CARBOLINE HYDROCHLORIDE DIHYDRATE
- CBNumber
- CB7730915
- Molecular Formula
- C12H12N2O.HCl.H2O
- Formula Weight
- 254.72
- MOL File
- 6028-00-8.mol
HARMALOL HYDROCHLORIDE DIHYDRATE Property
- Melting point:
- 265-268 °C (dec.)
- storage temp.
- Refrigerator (+4°C)
- solubility
- DMF:10.0(Max Conc. mg/mL);36.67(Max Conc. mM)
DMSO:1.0(Max Conc. mg/mL);3.67(Max Conc. mM)
Ethanol:2.0(Max Conc. mg/mL);7.33(Max Conc. mM) - form
- A solid
N-Bromosuccinimide Price
- Product number
- H125
- Product name
- Harmalol hydrochloride dihydrate
- Purity
- monoamine oxidase inhibitor
- Packaging
- 1g
- Price
- $256
- Updated
- 2022/05/15
- Product number
- H105153
- Product name
- Harmalol hydrochloride dihydrate
- Packaging
- 500mg
- Price
- $200
- Updated
- 2021/12/16
- Product number
- 279981
- Product name
- Harmalol hydrochloride dihydrate
- Packaging
- 250mg
- Price
- $347
- Updated
- 2021/12/16
- Product number
- FH52360
- Product name
- Harmalol hydrochloride dihydrate
- Packaging
- 250mg
- Price
- $75
- Updated
- 2021/12/16
- Product number
- FH52360
- Product name
- Harmalol hydrochloride dihydrate
- Packaging
- 500mg
- Price
- $125
- Updated
- 2021/12/16
HARMALOL HYDROCHLORIDE DIHYDRATE Chemical Properties,Usage,Production
Description
Harmalol is a β-carboline alkaloid and an active metabolite of harmaline that has been found in P. harmala and has diverse biological activities.1,2,3,4,5 It is an inhibitor of dual-specificity tyrosine phosphorylation-regulated kinase 1A (DYRK1A; IC50 = 0.63 µM) and monoamine oxidase A (MAO-A; IC50 = 0.66 µM).3 It is selective for DYRK1A over Cdk1, Cdk5, CK1α1, Clk4, DYRK2, Pim-1, and GSK3β but also inhibits DYRK1B and Clk1 at 10 µM. It inhibits proliferation of H4 human glioblastoma cells (IC50s = 23.7 µM). Harmalol (0.5-12.5 µM) reduces increases in the levels of the cytochrome P450 (CYP) isoform CYP1A1 induced by 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) in HepG2 cells and prevents TCDD-induced activation of the aryl hydrocarbon receptor (AhR) in guinea pig hepatic cytosolic extracts.4 It reduces glutamate-induced cytotoxicity, cytochrome c release, caspase-3 activation, and the production of reactive oxygen species (ROS) in PC12 cells when used at a concentration of 25 µM.5 This product is also available as an analytical reference standard (Item No. 35145).WARNING This product is not for human or veterinary use.
Chemical Properties
yellow crystalline powder
HARMALOL HYDROCHLORIDE DIHYDRATE Preparation Products And Raw materials
Raw materials
Preparation Products
HARMALOL HYDROCHLORIDE DIHYDRATE Suppliers
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