Penciclovir
- Product Name
- Penciclovir
- CAS No.
- 39809-25-1
- Chemical Name
- Penciclovir
- Synonyms
- PCV;CL200;VSA 671;Vectavir;BRL-39123;BRL-39123A;Penciceovir;PENCICLOVIR;PENCICLOVIR-D4;Penciclovir >
- CBNumber
- CB7731886
- Molecular Formula
- C10H15N5O3
- Formula Weight
- 253.26
- MOL File
- 39809-25-1.mol
Penciclovir Property
- Melting point:
- 275-277°C
- Boiling point:
- 653.4±65.0 °C(Predicted)
- Density
- 1.68±0.1 g/cm3(Predicted)
- storage temp.
- Keep in dark place,Sealed in dry,Store in freezer, under -20°C
- solubility
- 0.02 M potassium phosphate: soluble2mg/mL
- pka
- 14.42±0.10(Predicted)
- form
- White solid
- color
- White to Off-White
- λmax
- 253nm(H2O)(lit.)
- Merck
- 14,7083
- CAS DataBase Reference
- 39809-25-1(CAS DataBase Reference)
- EPA Substance Registry System
- 6H-Purin-6-one, 2-amino-1,9-dihydro-9-[4-hydroxy-3-(hydroxymethyl)butyl]- (39809-25-1)
Safety
- Hazard Codes
- Xi
- Risk Statements
- 36
- Safety Statements
- 26
- WGK Germany
- 3
- RTECS
- UP0789400
- HS Code
- 2933.99.8290
- Hazardous Substances Data
- 39809-25-1(Hazardous Substances Data)
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Danger
- Hazard statements
-
H225Highly Flammable liquid and vapour
H315Causes skin irritation
H319Causes serious eye irritation
- Precautionary statements
-
P210Keep away from heat/sparks/open flames/hot surfaces. — No smoking.
P233Keep container tightly closed.
P240Ground/bond container and receiving equipment.
P241Use explosion-proof electrical/ventilating/lighting/…/equipment.
P242Use only non-sparking tools.
P243Take precautionary measures against static discharge.
P264Wash hands thoroughly after handling.
P264Wash skin thouroughly after handling.
P280Wear protective gloves/protective clothing/eye protection/face protection.
P303+P361+P353IF ON SKIN (or hair): Remove/Take off Immediately all contaminated clothing. Rinse SKIN with water/shower.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
P332+P313IF SKIN irritation occurs: Get medical advice/attention.
P337+P313IF eye irritation persists: Get medical advice/attention.
P370+P378In case of fire: Use … for extinction.
P403+P235Store in a well-ventilated place. Keep cool.
N-Bromosuccinimide Price
- Product number
- P0035
- Product name
- Penciclovir
- Packaging
- 100mg
- Price
- $157.2
- Updated
- 2024/03/01
- Product number
- 516090-M
- Product name
- Penciclovir - CAS 39809-25-1 - Calbiochem
- Purity
- A carba analog of Ganciclovir. Active against several herpes viruses. Induces apoptosis effectively without exerting much genotoxicity.
- Packaging
- 100mg
- Price
- $201
- Updated
- 2022/05/15
- Product number
- 516090-M
- Product name
- Penciclovir - CAS 39809-25-1 - Calbiochem
- Purity
- A carba analog of Ganciclovir. Active against several herpes viruses. Induces apoptosis effectively without exerting much genotoxicity.
- Packaging
- 516090-100MG
- Price
- $220
- Updated
- 2022/05/15
- Product number
- P2164
- Product name
- Penciclovir
- Purity
- >98.0%(HPLC)(T)
- Packaging
- 200mg
- Price
- $186
- Updated
- 2024/03/01
- Product number
- P2164
- Product name
- Penciclovir
- Purity
- >98.0%(HPLC)(T)
- Packaging
- 1g
- Price
- $585
- Updated
- 2023/06/20
Penciclovir Chemical Properties,Usage,Production
Description
Vectavir was launched in the UK for herpes labialis. Penciclovir is synthetically available by two routes of four steps each from 2- (hydroxymethyl)butane-l,4-diol and is active against HSV-1, HSV-2 VZV but has limited activity against CMV. Vectavir is an acyclic guanosine analog that acts as a competitive inhibitor of DNA polymerase. It is a metabolic product of famcyclovir that is preferentially phosphorylated by viral infected cells (by thymidine kinases) over normal cells. The triphosphate has a low activity against cellular DNA polymerase which is one possible explanation for its low toxicity. While its spectrum of activity is similar to acyclovir, it is longer acting because its triphosphate is 20 times more stable and is not metabolized.
Chemical Properties
White Cyrstalline Solid
Originator
SmithKline Beecham (UK)
Uses
An antiviral.
Uses
A deuterated version of Penciclovir, an antiviral
Definition
ChEBI: A member of the class of 2-aminopurines that is guanine in which the hydrogen at position 9 is substituted by a 4-hydroxy-3-(hydroxymethyl)but-1-yl group. An antiviral drug, it is administered topically for treatment of herpes labialis. A prodrug, famciclo ir, is used for oral administration.
Indications
Penciclovir has activity against HSV-1, HSV-2, VZV, and HBV. After oral administration, famciclovir is converted to penciclovir by first-pass metabolism. Penciclovir has a mechanism of action similar to that of acyclovir. It is first monophosphorylated by viral thymidine kinase; then it is converted to a triphosphate by cellular kinases.
Manufacturing Process
To a suspension of lithium aluminum hydride (2.87 g, 76 mmol) in tetrahydrofuran (125 ml), a solution of triethyl 1,1,2-ethanetricarboxylate (9.2 ml, 9.85 g, 40 mmol) in tetrahydrofuran (25 ml) was added dropwise with stirring over 2 hours. The inorganic salts were filtered off and washed with ethanol (100 ml). The filtrate and washings were combined and the solvent was evaporated under reduced pressure to afford a colourless oil (4.85 g). To a suspension of this oil in acetone (100 ml) 2,2-dimethoxypropane (25 ml) and p-toluenesulphonic acid monohydrate (2.3 g, 12 mmol) were added. The mixture was stirred for 1 hour. The resulting solution was neutralised with Amberlite IR 45 (methanol washed), filtered and the solvent evaporated under reduced pressure. The residue was purified by column chromatography on silica gel, eluting with chloroform-methanol mixtures (40:1 and 25:1) to afford 5-(2-hydroxyethyl)-2,2-dimethyl-1,3-dioxan as a colourless liquid (3.01 g, 47%).
To an ice-cooled solution of 5-(2-hydroxyethyl)-2,2-dimethyl-1,3-dioxan (1.92 g, 12 mmol) and carbon tetrabromide (7.96 g, 24 mmol) in dimethylformamide (100 ml) triphenylphosphine (6.30 g, 24 mmol) was added and the solution was left at 4°C overnight. To this solution methanol (20 ml) was added and the solvent was then evaporated under reduced pressure. The residue was purified by column chromatography on silica gel, eluting with hexane-acetone (12:1) to afford 5-(2-bromoethyl)-2,2-dimethyl1,3-dioxan as a clear colourless liquid (0.89 g, 40%).
To a solution of 5-(2-bromoethyl)-2,2-dimethyl-1,3-dioxan (0.75 g, 3.7 mmol) in dry dimethylformamide (12 ml) 2-amino-6-chloropurine (0.68 g, 4.0 mmol) and then anhydrous potassium carbonate (0.83, 6.0 mmol) were added. The solution was stirred at room temperature for 5 hours and left at 4°C
overnight. The solution was filtered and the solvent removed. The residue was purified by column chromatography on silica gel, eluting with chloroformmethanol mixtures (80:1 and 60:1) to afford 2-amino-6-chloro-9-[2-(2,2dimethyl-1,3-dioxan-5-yl)ethyl]purine as a white crystalline solid (0.74 g, 64%), melting point 125°-126°C.
2-Amino-6-chloro-9-[2-(2,2-dimethyl-1,3-dioxan-5-yl)-ethyl]purine (0.59 g, 1.9 mmol) in hydrochloric acid (1.0 M, 4 ml) was stirred at 60°C for 24 hours. The solution was diluted with water and neutralised with Amberlite IR 45. The mixture was filtered, the resin washed with water and the solvent evaporated under reduced pressure. The residue was recrystallised from water to afford 9-(4-hydroxy-3-hydroxymethylbut-1-yl)guanine (238 mg, 49%), melting point 275°-277°C.
brand name
Denavir (SmithKline Beecham).
Therapeutic Function
Antiviral
Acquired resistance
Penciclovir is inactive against thymidine kinase-deficient strains of HSV.
Pharmaceutical Applications
A synthetic acyclic purine nucleoside analog, usually administered orally as the diacetyl ester, famciclovir, which acts as a prodrug undergoing rapid first-pass metabolism to release the active compound in vivo. The parent compound has virtually no oral bioavailability, but is supplied as a topical formulation.
Pharmacokinetics
Oral absorption, penciclovir： 5%
famciclovir： 77%
Cmax famciclovir 250 mg oral： 1.6 mg/L after 0.5–1.5 h
famciclovir 500 mg oral： 3.3 mg/L after 0.5–1.5 h
famciclovir 750 mg oral： 5.1 mg/L after 0.5–1.5 h
Plasma half-life： 2.1–2.7 h
Volume of distribution： c. 1.5 L/kg
Plasma protein binding： <20%
Following absorption famciclovir is converted rapidly by
enzyme-mediated deacetylation and oxidation to penciclovir.
Food does not lead to any significant change in the availability
or elimination.
The pharmacokinetics in elderly subjects are similar to
those seen in younger subjects, although small increases in
AUC and plasma half-lives were seen, consistent with slightly
decreased renal clearance.
Renal excretion is the major route of elimination, 50–60%
of an oral dose being recovered in the urine. After intravenous
infusion, about 70% is excreted unchanged in the urine.
After oral administration of famciclovir, penciclovir accounts
for 82% of urinary drug-related material. The remainder
includes metabolites, of which the largest is the 6-deoxy precursor
of penciclovir. Renal clearance exceeds glomerular filtration,
indicating renal tubular secretion.
Clinical Use
Herpes zoster and genital herpes
Orolabial herpes (topical)
Clinical Use
Penciclovir is approved as a topical formulation for the treatment of herpes labialis. In immunocompetent individuals, penciclovir shortens the duration of lesion presence and pain by approximately half a day when it is initiated within an hour of lesion development and applied every 2 hours during waking hours for 4 days.
Side effects
In clinical trials the incidence of adverse events after famciclovir, aciclovir and placebo were similar, the most common adverse events being headache and nausea.
References
[1] boyd m r, bacon t h, sutton d, et al. antiherpesvirus activity of 9-(4-hydroxy-3-hydroxy-methylbut-1-yl) guanine (brl 39123) in cell culture. antimicrobial agents and chemotherapy, 1987, 31(8): 1238-1242.
[2] hodge r a, perkins r m. mode of action of 9-(4-hydroxy-3-hydroxymethylbut-1-yl) guanine (brl 39123) against herpes simplex virus in mrc-5 cells. antimicrobial agents and chemotherapy, 1989, 33(2): 223-229.
Penciclovir Preparation Products And Raw materials
Raw materials
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View Lastest Price from Penciclovir manufacturers
- Product
- Penciclovir 39809-25-1
- Price
- US $0.00/Kg/Bag
- Min. Order
- 2Kg/Bag
- Purity
- GMP/ 99% up
- Supply Ability
- 20 tons
- Release date
- 2021-07-23
- Product
- Penciclovir 39809-25-1
- Price
- US $0.00/kg
- Min. Order
- 1kg
- Purity
- 99%
- Supply Ability
- 10000kg
- Release date
- 2024-05-06
- Product
- Penciclovir 39809-25-1
- Price
- US $0.00/Kg/Drum
- Min. Order
- 1KG
- Purity
- 99%-101%
- Supply Ability
- 100KGS
- Release date
- 2021-07-02