FMOC-SER-OME
- Product Name
- FMOC-SER-OME
- CAS No.
- 82911-78-2
- Chemical Name
- FMOC-SER-OME
- Synonyms
- FMOC-SER-OME;Fmoc-L-Ser-OMe;FMOC-SERINE-OME;Fmoc-Ser-Ome, ≥98%;Tryptophan Impurity 78;Ceftobiprole Impurity 19;FMOC-L-SERINE METHYL ESTER;Fmoc-L-β-hydroxyalanine methyl ester;Fmoc-L-serine methyl ester≥ 99.5% (HPLC);(9H-Fluoren-9-yl)MethOxy]Carbonyl Ser-OMe
- CBNumber
- CB7736311
- Molecular Formula
- C19H19NO5
- Formula Weight
- 341.36
- MOL File
- 82911-78-2.mol
FMOC-SER-OME Property
- Boiling point:
- 579.4±45.0 °C(Predicted)
- Density
- 1.285±0.06 g/cm3(Predicted)
- storage temp.
- Sealed in dry,2-8°C
- form
- Solid
- pka
- 10.07±0.46(Predicted)
- color
- White to off-white
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H315Causes skin irritation
H319Causes serious eye irritation
H335May cause respiratory irritation
- Precautionary statements
-
P261Avoid breathing dust/fume/gas/mist/vapours/spray.
P264Wash hands thoroughly after handling.
P264Wash skin thouroughly after handling.
P271Use only outdoors or in a well-ventilated area.
P280Wear protective gloves/protective clothing/eye protection/face protection.
P302+P352IF ON SKIN: wash with plenty of soap and water.
P304+P340IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
P312Call a POISON CENTER or doctor/physician if you feel unwell.
P321Specific treatment (see … on this label).
P332+P313IF SKIN irritation occurs: Get medical advice/attention.
P337+P313IF eye irritation persists: Get medical advice/attention.
P362Take off contaminated clothing and wash before reuse.
P403+P233Store in a well-ventilated place. Keep container tightly closed.
P405Store locked up.
P501Dispose of contents/container to..…
N-Bromosuccinimide Price
- Product number
- F861045
- Product name
- Fmoc-Ser-OMe
- Packaging
- 250mg
- Price
- $75
- Updated
- 2021/12/16
- Product number
- J96847
- Product name
- Fmoc-L-serinemethylester
- Packaging
- 250mg
- Price
- $15
- Updated
- 2021/12/16
- Product number
- AS88997
- Product name
- Fmoc-L-serine methyl ester
- Purity
- 97% ee
- Packaging
- 1g
- Price
- $49
- Updated
- 2021/12/16
- Product number
- 03925
- Product name
- Fmoc-L-serinemethylester,99.5%(HPLC)
- Purity
- 99.5%(HPLC)
- Packaging
- 250MG
- Price
- $56
- Updated
- 2021/12/16
- Product number
- 03925
- Product name
- Fmoc-L-serinemethylester,≥99.5%(HPLC)
- Purity
- ≥99.5%(HPLC)
- Packaging
- 1G
- Price
- $110.66
- Updated
- 2021/12/16
FMOC-SER-OME Chemical Properties,Usage,Production
Chemical Properties
White to off-white powder
Uses
Fmoc-Ser-OMe (Fmoc-L-Ser-OMe) is a hydroxylated L-amino acid protected with a 9-fluorenylmethyloxycarbonyl (Fmoc) group. Fmoc-Ser-OMe involves in chlorophyll–amino acid conjugates synthesis, and acts as a chromo/fluorophores modified protein and emits visible to near-infrared lights efficiently. Fmoc-Ser-OMe glycosylates and produces small mucin-related Olinked glycopeptides, as an alcohol acceptor[1][2].
Synthesis
5680-80-8
82911-69-1
82911-78-2
GENERAL STEPS: To a mixed solution of 1,4-dioxane (15 mL) and water (90 mL) containing L-serine methyl ester hydrochloride (10.0 g, 64.3 mmol), sodium bicarbonate (10.8 g, 129 mmol) was added. The reaction mixture was stirred at room temperature for 15 minutes. Subsequently, a solution of 1,4-dioxane (60 mL) of 2,5-dioxopyrrolidin-1-yl 9H-fluoren-9-ylmethyl carbonate (21.7 g, 64.3 mmol) was slowly added to the reaction system, and stirring was continued at room temperature for 14 hours. Upon completion of the reaction, water was added to the reaction mixture and extracted three times with ethyl acetate. The organic layers were combined and washed sequentially with water and saturated brine. The organic layer was dried over anhydrous magnesium sulfate, filtered and concentrated under reduced pressure. Ether and heptane were added to the residue and the precipitate was collected by filtration to give fmoc-L-serine methyl ester (22.3 g, yield: quantitative). The product was characterized by 1H-NMR (400 MHz, CDCl3): δ 2.00-2.15 (1H, m), 3.81 (3H, s), 3.89-4.07 (2H, m), 4.20-4.28 (1H, m), 4.39-4.53 (3H, m), 5.63-5.74 (1H, m), 7.29-7.37 (2H , m), 7.38-7.46 (2H, m), 7.55-7.65 (2H, m), 7.74-7.82 (2H, m).
References
[1] Tamiaki H, et al. Synthesis of chlorophyll-amino acid conjugates as models for modification of proteins with chromo/fluorophores. Bioorg Med Chem. 2014 Feb 15;22(4):1421-8. DOI:10.1016/j.bmc.2013.12.059
[2] K?rkk?inen TS, et al. Iodine-mediated glycosylation en route to mucin-related glyco-aminoacids and glycopeptides. Carbohydr Res. 2008 Jul 21;343(10-11):1830-4. DOI:10.1016/j.carres.2008.03.034
FMOC-SER-OME Preparation Products And Raw materials
Raw materials
Preparation Products
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View Lastest Price from FMOC-SER-OME manufacturers
- Product
- FMOC-SER-OME 82911-78-2
- Price
- US $1.00/KG
- Min. Order
- 1KG
- Purity
- 98%
- Supply Ability
- 20kg
- Release date
- 2018-08-22