ChemicalBook > CAS DataBase List > FMOC-SER-OME

FMOC-SER-OME

Product Name: FMOC-SER-OME
CAS No.: 82911-78-2
Chemical Name: FMOC-SER-OME
Synonyms: FMOC-SER-OME;Fmoc-L-Ser-OMe;FMOC-SERINE-OME;Fmoc-Ser-Ome, ≥98%;Tryptophan Impurity 78;Ceftobiprole Impurity 19;FMOC-L-SERINE METHYL ESTER;Fmoc-L-β-hydroxyalanine methyl ester;Fmoc-L-serine methyl ester≥ 99.5% (HPLC);(9H-Fluoren-9-yl)MethOxy]Carbonyl Ser-OMe
CBNumber: CB7736311
Molecular Formula: C19H19NO5
Formula Weight: 341.36
MOL File: 82911-78-2.mol

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FMOC-SER-OME Property

Boiling point:: 579.4±45.0 °C(Predicted)
Density: 1.285±0.06 g/cm3(Predicted)
storage temp.: Sealed in dry,2-8°C
form: Solid
pka: 10.07±0.46(Predicted)
color: White to off-white

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P271Use only outdoors or in a well-ventilated area.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P302+P352IF ON SKIN: wash with plenty of soap and water.

P304+P340IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

P312Call a POISON CENTER or doctor/physician if you feel unwell.

P321Specific treatment (see … on this label).

P332+P313IF SKIN irritation occurs: Get medical advice/attention.

P337+P313IF eye irritation persists: Get medical advice/attention.

P362Take off contaminated clothing and wash before reuse.

P403+P233Store in a well-ventilated place. Keep container tightly closed.

P405Store locked up.

P501Dispose of contents/container to..…

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N-Bromosuccinimide Price

TRC

Product number: F861045
Product name: Fmoc-Ser-OMe
Packaging: 250mg
Price: $75
Updated: 2021/12/16

AK Scientific

Product number: J96847
Product name: Fmoc-L-serinemethylester
Packaging: 250mg
Price: $15
Updated: 2021/12/16

Activate Scientific

Product number: AS88997
Product name: Fmoc-L-serine methyl ester
Purity: 97% ee
Packaging: 1g
Price: $49
Updated: 2021/12/16

Chem-Impex

Product number: 03925
Product name: Fmoc-L-serinemethylester,99.5%(HPLC)
Purity: 99.5%(HPLC)
Packaging: 250MG
Price: $56
Updated: 2021/12/16

Chem-Impex

Product number: 03925
Product name: Fmoc-L-serinemethylester,≥99.5%(HPLC)
Purity: ≥99.5%(HPLC)
Packaging: 1G
Price: $110.66
Updated: 2021/12/16

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FMOC-SER-OME Chemical Properties,Usage,Production

Chemical Properties

White to off-white powder

Uses

Fmoc-Ser-OMe (Fmoc-L-Ser-OMe) is a hydroxylated L-amino acid protected with a 9-fluorenylmethyloxycarbonyl (Fmoc) group. Fmoc-Ser-OMe involves in chlorophyll–amino acid conjugates synthesis, and acts as a chromo/fluorophores modified protein and emits visible to near-infrared lights efficiently. Fmoc-Ser-OMe glycosylates and produces small mucin-related Olinked glycopeptides, as an alcohol acceptor[1][2].

Synthesis

5680-80-8

82911-69-1

82911-78-2

GENERAL STEPS: To a mixed solution of 1,4-dioxane (15 mL) and water (90 mL) containing L-serine methyl ester hydrochloride (10.0 g, 64.3 mmol), sodium bicarbonate (10.8 g, 129 mmol) was added. The reaction mixture was stirred at room temperature for 15 minutes. Subsequently, a solution of 1,4-dioxane (60 mL) of 2,5-dioxopyrrolidin-1-yl 9H-fluoren-9-ylmethyl carbonate (21.7 g, 64.3 mmol) was slowly added to the reaction system, and stirring was continued at room temperature for 14 hours. Upon completion of the reaction, water was added to the reaction mixture and extracted three times with ethyl acetate. The organic layers were combined and washed sequentially with water and saturated brine. The organic layer was dried over anhydrous magnesium sulfate, filtered and concentrated under reduced pressure. Ether and heptane were added to the residue and the precipitate was collected by filtration to give fmoc-L-serine methyl ester (22.3 g, yield: quantitative). The product was characterized by 1H-NMR (400 MHz, CDCl3): δ 2.00-2.15 (1H, m), 3.81 (3H, s), 3.89-4.07 (2H, m), 4.20-4.28 (1H, m), 4.39-4.53 (3H, m), 5.63-5.74 (1H, m), 7.29-7.37 (2H , m), 7.38-7.46 (2H, m), 7.55-7.65 (2H, m), 7.74-7.82 (2H, m).

References

[1] Tamiaki H, et al. Synthesis of chlorophyll-amino acid conjugates as models for modification of proteins with chromo/fluorophores. Bioorg Med Chem. 2014 Feb 15;22(4):1421-8. DOI:10.1016/j.bmc.2013.12.059
[2] K?rkk?inen TS, et al. Iodine-mediated glycosylation en route to mucin-related glyco-aminoacids and glycopeptides. Carbohydr Res. 2008 Jul 21;343(10-11):1830-4. DOI:10.1016/j.carres.2008.03.034

FMOC-SER-OME Preparation Products And Raw materials

Raw materials

Preparation Products

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View Lastest Price from FMOC-SER-OME manufacturers

Career Henan Chemical Co

Product: FMOC-SER-OME 82911-78-2
Price: US $1.00/KG
Min. Order: 1KG
Purity: 98%
Supply Ability: 20kg
Release date: 2018-08-22

82911-78-2, FMOC-SER-OMERelated Search:

Fmoc-L-Glutamic acid gamma-methyl ester FMOC-L-BETA-HOMOMETHIONINE FMOC-ILE-OL Fmoc-Ile-OH Boc-L-Glutamic acid 1-benzyl ester Fmoc-D-Aspartic acid beta-tert-butyl ester FMOC-GLU-OALL Fmoc-L-Serine FMOC-SER-OME O-(2-Azido-4,6-O-benzylidene-2-deoxy-alpha-D-galactopyranosyl)-N-Fmoc-L-serine tert-Butyl Ester O-(2-Azido-4,6-O-benzylidene-2-deoxy-alpha-D-galactopyranosyl)-N-Fmoc-L-threonine tert-Butyl Ester FMOC-L-SER(TBU)-O-CH2-PHI-OCH2-CH2-COOH FMOC-SER(TBU)-OPFP Fmoc-O-tert·butyl-L-threonineN-carboxyanhydride 3-O-Benzoyl-N-acetyl-a-D-galactosaminyl-1-O-N-(Fmoc)serine Phenacylester NALPHA-FMOC-L-SERINE TERT-BUTYL ESTER FMOC-THR(TBU)-OPFP NALPHA-FMOC-L-THREONINE TERT-BUTYL ESTER

(S)-Methyl 2-((((9H-fluoren-9-yl)Methoxy)carbonyl)aMino)-3-hydroxypropanoate

FMOC-L-SERINE METHYL ESTER

FMOC-SERINE-OME

FMOC-SER-OME

N-ALPHA-(9-FLUORENYLMETHOXYCARBONYL)-L-SERINE METHYL ESTER

Fmoc-L-Ser-OMe

(S)-Fmoc-2-Amino-3-hydroxypropionic acid methyl ester

Fmoc-L-serine methyl ester≥ 99.5% (HPLC)

Fmoc-L-β-hydroxyalanine methyl ester

(9H-Fluoren-9-yl)MethOxy]Carbonyl Ser-OMe

Fmoc-Ser-Ome, ≥98%

Methyl (((9H-fluoren-9-yl)methoxy)carbonyl)-L-serinate

methyl (2S)-2-({[(9H-fluoren-9-yl)methoxy]carbonyl}amino)-3-hydroxypropanoate

N-[(9-fluorenylmethoxy)carbonyl]-L-serine methyl ester

Methyl (S)-2-[[[(9H-Fluoren-9-yl)methoxy]carbonyl]amino]-3-hydroxypropanoate

L-Serine, N-[(9H-fluoren-9-ylmethoxy)carbonyl]-, methyl ester

Ceftobiprole Impurity 19

Tryptophan Impurity 78

82911-78-2