ChemicalBook > CAS DataBase List > 1-NAPHTHYLACETYL SPERMINE TRIHYDROCHLORIDE

1-NAPHTHYLACETYL SPERMINE TRIHYDROCHLORIDE

Product Name
1-NAPHTHYLACETYL SPERMINE TRIHYDROCHLORIDE
CAS No.
1049731-36-3
Chemical Name
1-NAPHTHYLACETYL SPERMINE TRIHYDROCHLORIDE
Synonyms
NASPM (hydrochloride);1-NAPHTHYLACETYL SPERMINE TRIHYDROCHLORIDE;Naspm trihydrochloride (1-Naphthylacetyl spermine);1-Naphthyl acetyl spermine (NASPM) trihydrochloride;inhibit,Inhibitor,Naspm trihydrochloride,iGluR,Ionotropic glutamate receptors
CBNumber
CB7736755
Molecular Formula
C22H35ClN4O
Formula Weight
407
MOL File
Mol file
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1-NAPHTHYLACETYL SPERMINE TRIHYDROCHLORIDE Property

Melting point:
>253°C (dec.)
storage temp. 
desiccated protect from light
solubility 
H2O: 23 mg/mL
form 
solid
color 
white
Water Solubility 
Soluble in water (100mM)
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Safety

Safety Statements 
22-24/25
WGK Germany 
3
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Hazard and Precautionary Statements (GHS)

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N-Bromosuccinimide Price

Sigma-Aldrich
Product number
N193
Product name
1-Naphthylacetyl spermine trihydrochloride
Packaging
5MG
Price
$189
Updated
2023/06/20
Sigma-Aldrich
Product number
N193
Product name
1-Naphthylacetyl spermine trihydrochloride
Packaging
25MG
Price
$647
Updated
2023/06/20
Cayman Chemical
Product number
18453
Product name
NASPM (hydrochloride)
Purity
≥95%
Packaging
1mg
Price
$25
Updated
2024/03/01
Cayman Chemical
Product number
18453
Product name
NASPM (hydrochloride)
Purity
≥95%
Packaging
5mg
Price
$94
Updated
2024/03/01
Cayman Chemical
Product number
18453
Product name
NASPM (hydrochloride)
Purity
≥95%
Packaging
10mg
Price
$135
Updated
2024/03/01
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1-NAPHTHYLACETYL SPERMINE TRIHYDROCHLORIDE Chemical Properties,Usage,Production

Chemical Properties

White Solid

Uses

1-Naphthylacetyl Spermine Trihydrochloride is a poliamine amide as potent Spermidine uptake inhibitor.

Biological Activity

naspm trihydrochloride is a selective antagonist of ca2+-permeable α-amino-3-hydroxy-5-methyl-4-isoxazole propionic acid (ampa) receptors. ampa receptors are glutamate-gated ion channels that play central roles in the mammalian brain, mediating fast excitatory synaptic transmission and underlying several forms of synaptic plasticity. on excitatory neurons in adult animals, two types of ampa receptors are primarily expressed, namely heteromeric channels composed of glur1 and glur2 subunits (glur1/2 receptors), as well as channels composed of glur2 and glur3 subunits (glur2/3 receptors). naspm trihydrochloride blocks ampa receptors lacking the glur2 subunit, with an ic50 value of 0.3 μm for glur1 homomers.1. nilsen a, england pm. a subtype-selective, use-dependent inhibitor of native ampa receptors. journal of the american chemical society, 2007, 129(16): 4902-4903.2. koike m, iino m, ozawa s. blocking effect of 1-naphthyl acetyl spermine on ca2+-permeable ampa receptors in cultured rat hippocampal neurons. neuroscience research, 1997, 29(1): 27-36.

Biochem/physiol Actions

Blocks Ca2+ permeable AMPA receptor channels.

storage

+4°C (desiccate)

1-NAPHTHYLACETYL SPERMINE TRIHYDROCHLORIDE Preparation Products And Raw materials

Raw materials

Preparation Products

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1-NAPHTHYLACETYL SPERMINE TRIHYDROCHLORIDE Suppliers

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View Lastest Price from 1-NAPHTHYLACETYL SPERMINE TRIHYDROCHLORIDE manufacturers

Career Henan Chemical Co
Product
1-NAPHTHYLACETYL SPERMINE TRIHYDROCHLORIDE 1049731-36-3
Price
US $1.00/KG
Min. Order
1KG
Purity
99.0%
Supply Ability
100kg
Release date
2020-01-18

1049731-36-3, 1-NAPHTHYLACETYL SPERMINE TRIHYDROCHLORIDERelated Search:

BIS(3-AMINOPROPYL) ETHER Aminosilane

  • 1-NAPHTHYLACETYL SPERMINE TRIHYDROCHLORIDE
  • NASPM (hydrochloride)
  • 1-Naphthyl acetyl spermine (NASPM) trihydrochloride
  • Naspm trihydrochloride (1-Naphthylacetyl spermine)
  • inhibit,Inhibitor,Naspm trihydrochloride,iGluR,Ionotropic glutamate receptors
  • 1049731-36-3
  • Amines
  • Aromatics
  • Inhibitors
  • Intermediates & Fine Chemicals
  • Pharmaceuticals