1-NAPHTHYLACETYL SPERMINE TRIHYDROCHLORIDE

ChemicalBook > CAS DataBase List > 1-NAPHTHYLACETYL SPERMINE TRIHYDROCHLORIDE

1-NAPHTHYLACETYL SPERMINE TRIHYDROCHLORIDE

Product Name: 1-NAPHTHYLACETYL SPERMINE TRIHYDROCHLORIDE
CAS No.: 1049731-36-3
Chemical Name: 1-NAPHTHYLACETYL SPERMINE TRIHYDROCHLORIDE
Synonyms: NASPM (hydrochloride);1-NAPHTHYLACETYL SPERMINE TRIHYDROCHLORIDE;Naspm trihydrochloride (1-Naphthylacetyl spermine);1-Naphthyl acetyl spermine (NASPM) trihydrochloride;inhibit,Inhibitor,Naspm trihydrochloride,iGluR,Ionotropic glutamate receptors;N-(3-((4-((3-Aminopropyl)amino)butyl)amino)propyl)-2-(naphthalen-1-yl)acetamide trihydrochloride
CBNumber: CB7736755
Molecular Formula: C22H35ClN4O
Formula Weight: 407
MOL File: Mol file

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1-NAPHTHYLACETYL SPERMINE TRIHYDROCHLORIDE Property

Melting point:: >253°C (dec.)
storage temp.: desiccated protect from light
solubility: H₂O: 23 mg/mL
form: solid
color: white
Water Solubility: Soluble in water (100mM)

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Safety

Safety Statements: 22-24/25
WGK Germany: 3

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Hazard and Precautionary Statements (GHS)

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N-Bromosuccinimide Price

Sigma-Aldrich

Product number: N193
Product name: 1-Naphthylacetyl spermine trihydrochloride
Packaging: 5MG
Price: $189
Updated: 2023/06/20

Sigma-Aldrich

Product number: N193
Product name: 1-Naphthylacetyl spermine trihydrochloride
Packaging: 25MG
Price: $647
Updated: 2023/06/20

Cayman Chemical

Product number: 18453
Product name: NASPM (hydrochloride)
Purity: ≥95%
Packaging: 1mg
Price: $25
Updated: 2024/03/01

Cayman Chemical

Product number: 18453
Product name: NASPM (hydrochloride)
Purity: ≥95%
Packaging: 5mg
Price: $94
Updated: 2024/03/01

Cayman Chemical

Product number: 18453
Product name: NASPM (hydrochloride)
Purity: ≥95%
Packaging: 10mg
Price: $135
Updated: 2024/03/01

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1-NAPHTHYLACETYL SPERMINE TRIHYDROCHLORIDE Chemical Properties,Usage,Production

Chemical Properties

White Solid

Uses

1-Naphthylacetyl Spermine Trihydrochloride is a poliamine amide as potent Spermidine uptake inhibitor.

Biological Activity

naspm trihydrochloride is a selective antagonist of ca2+-permeable α-amino-3-hydroxy-5-methyl-4-isoxazole propionic acid (ampa) receptors. ampa receptors are glutamate-gated ion channels that play central roles in the mammalian brain, mediating fast excitatory synaptic transmission and underlying several forms of synaptic plasticity. on excitatory neurons in adult animals, two types of ampa receptors are primarily expressed, namely heteromeric channels composed of glur1 and glur2 subunits (glur1/2 receptors), as well as channels composed of glur2 and glur3 subunits (glur2/3 receptors). naspm trihydrochloride blocks ampa receptors lacking the glur2 subunit, with an ic50 value of 0.3 μm for glur1 homomers.1. nilsen a, england pm. a subtype-selective, use-dependent inhibitor of native ampa receptors. journal of the american chemical society, 2007, 129(16): 4902-4903.2. koike m, iino m, ozawa s. blocking effect of 1-naphthyl acetyl spermine on ca2+-permeable ampa receptors in cultured rat hippocampal neurons. neuroscience research, 1997, 29(1): 27-36.

Biochem/physiol Actions

Blocks Ca2+ permeable AMPA receptor channels.

storage

+4°C (desiccate)

1-NAPHTHYLACETYL SPERMINE TRIHYDROCHLORIDE Preparation Products And Raw materials

Raw materials

Preparation Products

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View Lastest Price from 1-NAPHTHYLACETYL SPERMINE TRIHYDROCHLORIDE manufacturers

Career Henan Chemical Co

Product: 1-NAPHTHYLACETYL SPERMINE TRIHYDROCHLORIDE 1049731-36-3
Price: US $1.00/KG
Min. Order: 1KG
Purity: 99.0%
Supply Ability: 100kg
Release date: 2020-01-18

1049731-36-3, 1-NAPHTHYLACETYL SPERMINE TRIHYDROCHLORIDERelated Search:

BIS(3-AMINOPROPYL) ETHER Aminosilane

1-NAPHTHYLACETYL SPERMINE TRIHYDROCHLORIDE

NASPM (hydrochloride)

1-Naphthyl acetyl spermine (NASPM) trihydrochloride

Naspm trihydrochloride (1-Naphthylacetyl spermine)

inhibit,Inhibitor,Naspm trihydrochloride,iGluR,Ionotropic glutamate receptors

N-(3-((4-((3-Aminopropyl)amino)butyl)amino)propyl)-2-(naphthalen-1-yl)acetamide trihydrochloride

1049731-36-3

Amines

Aromatics

Inhibitors

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