1-NAPHTHYLACETYL SPERMINE TRIHYDROCHLORIDE
- Product Name
- 1-NAPHTHYLACETYL SPERMINE TRIHYDROCHLORIDE
- CAS No.
- 1049731-36-3
- Chemical Name
- 1-NAPHTHYLACETYL SPERMINE TRIHYDROCHLORIDE
- Synonyms
- NASPM (hydrochloride);1-NAPHTHYLACETYL SPERMINE TRIHYDROCHLORIDE;Naspm trihydrochloride (1-Naphthylacetyl spermine);1-Naphthyl acetyl spermine (NASPM) trihydrochloride;inhibit,Inhibitor,Naspm trihydrochloride,iGluR,Ionotropic glutamate receptors;N-(3-((4-((3-Aminopropyl)amino)butyl)amino)propyl)-2-(naphthalen-1-yl)acetamide trihydrochloride
- CBNumber
- CB7736755
- Molecular Formula
- C22H35ClN4O
- Formula Weight
- 407
- MOL File
- Mol file
1-NAPHTHYLACETYL SPERMINE TRIHYDROCHLORIDE Property
- Melting point:
- >253°C (dec.)
- storage temp.
- desiccated protect from light
- solubility
- H2O: 23 mg/mL
- form
- solid
- color
- white
- Water Solubility
- Soluble in water (100mM)
Safety
- Safety Statements
- 22-24/25
- WGK Germany
- 3
N-Bromosuccinimide Price
- Product number
- N193
- Product name
- 1-Naphthylacetyl spermine trihydrochloride
- Packaging
- 5MG
- Price
- $189
- Updated
- 2023/06/20
- Product number
- N193
- Product name
- 1-Naphthylacetyl spermine trihydrochloride
- Packaging
- 25MG
- Price
- $647
- Updated
- 2023/06/20
- Product number
- 18453
- Product name
- NASPM (hydrochloride)
- Purity
- ≥95%
- Packaging
- 1mg
- Price
- $25
- Updated
- 2024/03/01
- Product number
- 18453
- Product name
- NASPM (hydrochloride)
- Purity
- ≥95%
- Packaging
- 5mg
- Price
- $94
- Updated
- 2024/03/01
- Product number
- 18453
- Product name
- NASPM (hydrochloride)
- Purity
- ≥95%
- Packaging
- 10mg
- Price
- $135
- Updated
- 2024/03/01
1-NAPHTHYLACETYL SPERMINE TRIHYDROCHLORIDE Chemical Properties,Usage,Production
Chemical Properties
White Solid
Uses
1-Naphthylacetyl Spermine Trihydrochloride is a poliamine amide as potent Spermidine uptake inhibitor.
Biological Activity
naspm trihydrochloride is a selective antagonist of ca2+-permeable α-amino-3-hydroxy-5-methyl-4-isoxazole propionic acid (ampa) receptors. ampa receptors are glutamate-gated ion channels that play central roles in the mammalian brain, mediating fast excitatory synaptic transmission and underlying several forms of synaptic plasticity. on excitatory neurons in adult animals, two types of ampa receptors are primarily expressed, namely heteromeric channels composed of glur1 and glur2 subunits (glur1/2 receptors), as well as channels composed of glur2 and glur3 subunits (glur2/3 receptors). naspm trihydrochloride blocks ampa receptors lacking the glur2 subunit, with an ic50 value of 0.3 μm for glur1 homomers.1. nilsen a, england pm. a subtype-selective, use-dependent inhibitor of native ampa receptors. journal of the american chemical society, 2007, 129(16): 4902-4903.2. koike m, iino m, ozawa s. blocking effect of 1-naphthyl acetyl spermine on ca2+-permeable ampa receptors in cultured rat hippocampal neurons. neuroscience research, 1997, 29(1): 27-36.
Biochem/physiol Actions
Blocks Ca2+ permeable AMPA receptor channels.
storage
+4°C (desiccate)
1-NAPHTHYLACETYL SPERMINE TRIHYDROCHLORIDE Preparation Products And Raw materials
Raw materials
Preparation Products
1-NAPHTHYLACETYL SPERMINE TRIHYDROCHLORIDE Suppliers
- Tel
- --
- Fax
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- Country
- Switzerland
- ProdList
- 6896
- Advantage
- 91
View Lastest Price from 1-NAPHTHYLACETYL SPERMINE TRIHYDROCHLORIDE manufacturers
- Product
- 1-NAPHTHYLACETYL SPERMINE TRIHYDROCHLORIDE 1049731-36-3
- Price
- US $1.00/KG
- Min. Order
- 1KG
- Purity
- 99.0%
- Supply Ability
- 100kg
- Release date
- 2020-01-18