4-CHLOROSULFONYLPHENYLPIVALATE
Uses- Product Name
- 4-CHLOROSULFONYLPHENYLPIVALATE
- CAS No.
- 150374-99-5
- Chemical Name
- 4-CHLOROSULFONYLPHENYLPIVALATE
- Synonyms
- phenyl pivalate;4-(Chlorosulfonyl);Severus Impurity 4;Sivelestat Impurity 3;Severlastat Impurity 3;Sivelestat sodium Impurity B;4-CHLOROSULFONYLPHENYLPIVALATE;4-(chlorosufonyl)phenylplvalate;p-Pivaloyloxybenzenesulfonyl chloride;4-CHLOROSULFONYLPHENYLPIVALATE ISO 9001：2015 REACH
- CBNumber
- CB7743999
- Molecular Formula
- C11H13ClO4S
- Formula Weight
- 276.74
- MOL File
- 150374-99-5.mol
4-CHLOROSULFONYLPHENYLPIVALATE Property
- Melting point:
- 83-87℃
- Boiling point:
- 355.6±25.0 °C(Predicted)
- Density
- 1.297
- storage temp.
- under inert gas (nitrogen or Argon) at 2-8°C
- InChI
- InChI=1S/C11H13ClO4S/c1-11(2,3)10(13)16-8-4-6-9(7-5-8)17(12,14)15/h4-7H,1-3H3
- InChIKey
- BSRSTUAZWZWGRT-UHFFFAOYSA-N
- SMILES
- C(OC1=CC=C(S(Cl)(=O)=O)C=C1)(=O)C(C)(C)C
Safety
- HS Code
- 2904990090
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Danger
- Hazard statements
-
H314Causes severe skin burns and eye damage
- Precautionary statements
-
P280Wear protective gloves/protective clothing/eye protection/face protection.
P301+P330+P331IF SWALLOWED: Rinse mouth. Do NOT induce vomiting.
P304+P340IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing.
N-Bromosuccinimide Price
- Product number
- OR926337
- Product name
- 4-(Chlorosulfonyl)phenylpivalate
- Purity
- 95%
- Packaging
- 250mg
- Price
- $180
- Updated
- 2021/12/16
- Product number
- 090368
- Product name
- 4-(Chlorosulfonyl)phenyl pivalate
- Purity
- 95+%
- Packaging
- 250mg
- Price
- $198
- Updated
- 2021/12/16
- Product number
- 090368
- Product name
- 4-(Chlorosulfonyl)phenyl pivalate
- Purity
- 95+%
- Packaging
- 1g
- Price
- $437
- Updated
- 2021/12/16
- Product number
- HCH0354722
- Product name
- 4-(CHLOROSULFONYL)PHENYL PIVALATE
- Purity
- 95.00%
- Packaging
- 5MG
- Price
- $497.5
- Updated
- 2021/12/16
- Product number
- 143901
- Product name
- 3-(4-(Chlorosulfonyl)phenyl)-2,2-dimethylpropanoate
- Purity
- 95%
- Packaging
- 1g
- Price
- $596
- Updated
- 2021/12/16
4-CHLOROSULFONYLPHENYLPIVALATE Chemical Properties,Usage,Production
Uses
p-Ponyloxybenzenesulfonyl chloride is a sulfonyl derivative that can be used as a pharmaceutical intermediate.
Synthesis Reference(s)
Synthetic Communications, 23, p. 1835, 1993 DOI: 10.1080/00397919308011284
Synthesis
3282-30-2
825-90-1
150374-99-5
General procedure for the synthesis of p-neopentanoyloxybenzenesulfonyl chloride from p-pivaloyl chloride and sodium 4-hydroxybenzenesulfonate: sodium 4-hydroxybenzenesulfonate (3) (1.0 g, 0.0049 mol) was dissolved in dichloromethane (DCM) (6 ml), triethylamine (TEA) (1.0 g, 0.0098 mol) was added, and p-neopentanoyl chloride was added slowly dropwise at 20 °C (0.84 g, 0.0069 mol). After the drop was completed, the reaction mixture was magnetically stirred at 20-25°C for about 5 minutes. Subsequently, the mixture was continued to be stirred at 20-25 °C for 2 h, during which the progress of the reaction was monitored by HPLC. Upon completion of the reaction, N,N-dimethylformamide (DMF) (0.11 g, 0.0015 mol) was added and thionyl chloride (0.77 g, 0.0064 mol) was added slowly and dropwise over 15 min at 20-25 °C. Stirring was continued at this temperature for 2 h and the reaction was monitored by HPLC. Upon completion of the reaction, the solvent was removed by evaporation under reduced pressure, toluene (10 ml) was added to dissolve the residue, the salts were removed by filtration, and the filtrate was concentrated under reduced pressure. To the concentrated residue was added n-hexane (5 ml), cooled to 0 °C, the resulting suspension was filtered and the product was washed with n-hexane to give 1.1 g of light yellow solid in 81.1% yield.
References
[1] Patent: JP5746484, 2015, B2. Location in patent: Paragraph 0003; 0006; 0009; 0015; 0036; 0037
4-CHLOROSULFONYLPHENYLPIVALATE Preparation Products And Raw materials
Raw materials
Preparation Products
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View Lastest Price from 4-CHLOROSULFONYLPHENYLPIVALATE manufacturers
- Product
- 4-(Chlorosulfonyl)phenyl pivalate 150374-99-5
- Price
- US $20.70/KG
- Min. Order
- 1KG
- Purity
- 99%
- Supply Ability
- 100KG
- Release date
- 2021-10-08
- Product
- 4-(Chlorosulfonyl)phenyl pivalate 150374-99-5
- Price
- US $20.70/KG
- Min. Order
- 1KG
- Purity
- 99%
- Supply Ability
- 10kg
- Release date
- 2021-10-08
- Product
- 4-CHLOROSULFONYLPHENYLPIVALATE 150374-99-5
- Price
- US $2.00/KG
- Min. Order
- 1KG
- Purity
- 98%
- Supply Ability
- 100g , 1kg, 5kg , 50kg
- Release date
- 2020-01-07