2-CHLORO-2-HYDROXYIMINOACETIC ACID ETHYL ESTER

Product Name: 2-CHLORO-2-HYDROXYIMINOACETIC ACID ETHYL ESTER
CAS No.: 14337-43-0
Chemical Name: 2-CHLORO-2-HYDROXYIMINOACETIC ACID ETHYL ESTER
Synonyms: ethyl (Z)-2-chloro-2-(hydroxyimino)acetate;CHLOROOXIME;ETHYL CHLOROOXIMIDOACETATE;ETHYL 2-CHLORO-2-(HYDROXYIMINO)ACETATE;AKOS MSC-0743;ZERENEX ZX011529;Ethyl 2-chloro-2-(;TIMTEC-BB SBB009890;ETHYLCHLOROXIMIDOACETATE;Ethylchloroximide acetate
CBNumber: CB7744567
Molecular Formula: C4H6ClNO3
Formula Weight: 151.55
MOL File: 14337-43-0.mol

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2-CHLORO-2-HYDROXYIMINOACETIC ACID ETHYL ESTER Property

Melting point:: 70-76 °C (lit.)
Boiling point:: 230.5±23.0 °C(Predicted)
Density: 1.36±0.1 g/cm3(Predicted)
storage temp.: 2-8°C
solubility: soluble in Methanol
form: powder to crystal
pka: 7.60±0.10(Predicted)
color: White to Almost white
Sensitive: Moisture Sensitive/Lachrymatory
BRN: 606193
InChI: InChI=1S/C4H6ClNO3/c1-2-9-4(7)3(5)6-8/h8H,2H2,1H3
InChIKey: UXOLDCOJRAMLTQ-UHFFFAOYSA-N
SMILES: C(OCC)(=O)C(Cl)=NO
CAS DataBase Reference: 14337-43-0(CAS DataBase Reference)

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Safety

Hazard Codes: Xn,Xi
Risk Statements: 37/38-41-42/43-36/37/38
Safety Statements: 22-26-36/37/39-45-36
RIDADR: UN 3335
WGK Germany: 3
F: 10-19-21
HazardClass: 9
HS Code: 29280000

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Danger

Hazard statements

H315Causes skin irritation

H318Causes serious eye damage

H334May cause allergy or asthma symptoms or breathing difficulties if inhaled

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

P342+P311IF experiencing respiratory symptoms: call a POISON CENTER or doctor/physician.

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N-Bromosuccinimide Price

Sigma-Aldrich

Product number: 292621
Product name: Ethyl 2-chloro-2-(hydroxyimino)acetate
Purity: 97%
Packaging: 5g
Price: $55.8
Updated: 2025/07/31

Sigma-Aldrich

Product number: 292621
Product name: Ethyl 2-chloro-2-(hydroxyimino)acetate
Purity: 97%
Packaging: 25g
Price: $122
Updated: 2025/07/31

TCI Chemical

Product number: E0371
Product name: Ethyl 2-Chloro-2-(hydroxyimino)acetate
Purity: >99.0%(T)
Packaging: 5g
Price: $41
Updated: 2025/07/31

TCI Chemical

Product number: E0371
Product name: Ethyl 2-Chloro-2-(hydroxyimino)acetate
Purity: >99.0%(T)
Packaging: 25g
Price: $114
Updated: 2025/07/31

TRC

Product number: E901990
Product name: Ethyl 2-Chloro-2-(hydroxyimino)acetate
Packaging: 10g
Price: $105
Updated: 2021/12/16

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2-CHLORO-2-HYDROXYIMINOACETIC ACID ETHYL ESTER Chemical Properties,Usage,Production

Chemical Properties

off-white solid

Uses

Ethyl 2-chloro-2-(hydroxyimino)acetate has been used:

in the preparation of (+)-and (?)-Δ²-isoxazolines
in the synthesis of CIP-AS (?), a chiral amino acid structurally related to glutamic acid, potential agonist at the ionotropic (±±)-2-amino-3-(3-hydroxy-5-methylisoxazol-4-yl)propionic acid (AMPA)-kainate receptors
to generate ethoxycarbonylformonitrile oxide, in situ by treatment with sodium bicarbonate
to prepare N-azirdinyloximes which on treatment with scandium triflate (418218) provide dihydro-oxadiazines

Synthesis

459-73-4

14337-43-0

General procedure for the synthesis of ethyl chlorooxime acetate from ethyl 2-aminoacetate: ethyl aminoacetate (5 g, 48.53 mmol) was dissolved in water (5 ml) to form a solution. To this solution, concentrated hydrochloric acid (8 ml) was slowly added at 0°C, followed by a mixture of sodium nitrite (NaNO2, 4.91 g, 145.6 mmol) and water (5 ml). The reaction mixture was stirred at room temperature for 1 hour. After completion of the reaction, the reaction mixture was extracted with ethyl acetate. The organic layers were combined and dried over anhydrous sodium sulfate (Na2SO4) and subsequently concentrated under vacuum to give ethyl chloroxime acetate (1.5 g, 20% yield) as a white solid.1H NMR (400 MHz, CDCl3): δ 1.37-1.41 (t, J = 7.2 Hz, 3H); 4.38-4.43 (q, J = 7.2 Hz, 2H). 9.59-9.61 (m, 1H).

References

[1] Patent: WO2009/118759, 2009, A2. Location in patent: Page/Page column 113
[2] Journal of Heterocyclic Chemistry, 1964, vol. 1, p. 280 - 287
[3] Patent: CN108440435, 2018, A. Location in patent: Paragraph 0024; 0027; 0029; 0038

2-CHLORO-2-HYDROXYIMINOACETIC ACID ETHYL ESTER Preparation Products And Raw materials

Raw materials

Preparation Products

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2-CHLORO-2-HYDROXYIMINOACETIC ACID ETHYL ESTER Suppliers

Americas 1 China 171 Europe 2 Germany 4 India 8 Japan 1 Switzerland 1 The Netherlands 1 United Kingdom 14 United States 35 Global 238

Tianjing Geneston Bio-tech Co.,Ltd.

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View Lastest Price from 2-CHLORO-2-HYDROXYIMINOACETIC ACID ETHYL ESTER manufacturers

Weijer International Trade (Hebei) Co., Ltd

Product: Ethyl (2Z)-chloro(hydroxyimino)acetate 14337-43-0
Price: US $50.00/KG
Min. Order: 1KG
Purity: >99%
Supply Ability: 20tons
Release date: 2023-03-16

Anhui Rencheng Technology Co., Ltd

Product: Ethyl (2Z)-chloro(hydroxyimino)acetate 14337-43-0
Price: US $1.00/KG
Min. Order: 0.5KG
Purity: >99%
Supply Ability: 20tons
Release date: 2020-12-29

Honest Joy Holdings Limited

Product: 2-Chloro-2-hydroxyiminoacetic acid ethyl ester 14337-43-0
Price: US $0.00/KG
Min. Order: 1KG
Purity: 99.0%
Supply Ability: 100 tons
Release date: 2022-01-26

14337-43-0, 2-CHLORO-2-HYDROXYIMINOACETIC ACID ETHYL ESTERRelated Search:

9-Fluorenylmethyl chloroformate ChloroMethyl Methyl Carbonate Chloromethyl chlorosulfate 2-chloroethoxyacetonitrile ETHYL (METHYLTHIO)ACETATE Acetaldoxime FORMALDOXIME HYDROCHLORIDE Methyl chloroacetate Ethyl chloroacetate 2-CHLORO-2-HYDROXYIMINOACETIC ACID ETHYL ESTER Oxalyl chloride 2-Chloroethyl ethyl ether Chloroacetic acid

Ethyl 2-chloro-2-(hydroxyimino)acetate 97%

(2Z)-2-chloro-2-hydroximino-acetic acid ethyl ester

(2Z)-2-chloro-2-hydroxyiminoacetic acid ethyl ester

ETHYLCHLOROXIMIDOACETATE

ETHYL CHLOROOXIMIDOACETATE

Ethyl 2-chloro-2-(hydroxyimino)ethanoate

2-chloro-2-hydroximino-acetic acid ethyl ester

ethyl (2Z)-2-chloro-2-hydroxyiminoacetate

ethyl (2Z)-2-chloro-2-hydroxyimino-acetate

ethyl (2Z)-2-chloro-2-hydroxyimino-ethanoate

ethyl (2Z)-chloro(hydroxyimino)acetate

Ethyl 2-chloro-2-(

2-chloro-2-hydroxyliminoacetic acid ethyl ester

ethyle2-chloro-2-(hydroxyimino)acetate

2-CHLORO-2-HYDROXYIMINOACETIC ACID ETHYL ESTER(Cas number：14337-43-0)

ETHYL CHLOROOXIMINOACETATE

ETHYL 2-CHLORO-2-(HYDROXYIMINO)ACETATE

2-CHLORO-2-HYDROXYIMINOACETIC ACID ETHYL ESTER

AKOS MSC-0743

ALPHA-CHLOROGLYOXALIC ACID ETHYL ESTER OXIME

1-ETHYL OXALYL CHLORIDE 2-OXIME

TIMTEC-BB SBB009890

ZERENEX ZX011529

2-CHLORO-2-HYDROXYIMINOACETIC ACID ETHYL ESTER 99+%

Ethyl chloro(hydroxyimino)acetic acid

2-CHLORO-2-HYDROXYIMINACETIC ACID ACID ETHYL ESTER

2-chloro-2-hydroxyiminocetic

CHLOROOXIME

2-(Hydroxyimino)-2-chloroacetic acid ethyl ester

Chloro(hydroxyimino)acetic acid ethyl ester

Ethylchloroximide acetate

Hydroxyiminochloroacetic acid ethyl ester

α-Chloroglyoxalic acid ethyl ester oxime

Acetic acid, chloro(hydroxyimino)-, ethyl ester

(Z)-ethyl 2-chloro-2-(hydroxyimino)acetate

(Z)-chloro-(hydroxyimino)acetic acid ethyl ester

Ethyl chloro(hydroxyimino)acetate

Ethyl chloro(hydroxyimino)ethanoate, 1-Ethyl oxalyl chloride 2-oxime

Acetic acid, 2-chloro-2-(hydroxyiMino)-, ethyl ester

alpha-Chloroglyoxalic Acid Ethyl Ester Oxime 2-Chloro-2-(hydroxyimino)acetic Acid Ethyl Ester Ethylchloroximidoacetate

Ethyl2-Chloro-2-(hydroxyimino)acetate&gt

oro-2-(hydroxyimino)acetate

ethyl (Z)-2-chloro-2-(hydroxyimino)acetate

Chlorooxime ethyl acetate

Ethyl2-chloro-2-oximinoacetate

2-Chloro-2-hydroxyiminoacetic acid ethyl ester - [E2979]

14337-43-0

144337-43-0

HONCClCO2C2H5

Organic Building Blocks

Esters

Building Blocks

C2 to C5

Carbonyl Compounds

API

Acids and Derivatives