H-TRP-GLU-OH

Product Name: H-TRP-GLU-OH
CAS No.: 36099-95-3
Chemical Name: H-TRP-GLU-OH
Synonyms: WE;G3335;TRP-GLU;L-TRP-GLU;H-TRP-GLU-OH;TRP-GLU CRYSTALLINE;PPARγ Antagonist III,G3335;L-TRYPTOPHYL-L-GLUTAMIC ACID;L-Glutamic acid, L-tryptophyl-;PPARγ Antagonist III, G3335 - CAS 36099-95-3 - Calbiochem
CBNumber: CB7745599
Molecular Formula: C16H19N3O5
Formula Weight: 333.34
MOL File: 36099-95-3.mol

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H-TRP-GLU-OH Property

Melting point:: >163°C(dec.)
Boiling point:: 720.7±60.0 °C(Predicted)
Density: 1.428±0.06 g/cm3(Predicted)
storage temp.: -15°C
solubility: Chloroform (Slightly), DMSO (Slightly)
form: White solid
pka: 3.02±0.10(Predicted)
color: white to off-white
Sensitive: Light Sensitive

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Hazard and Precautionary Statements (GHS)

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N-Bromosuccinimide Price

Sigma-Aldrich

Product number: SML1449
Product name: G3335
Purity: ≥98% (HPLC)
Packaging: 50mg
Price: $118
Updated: 2024/03/01

Sigma-Aldrich

Product number: 516566
Product name: PPARγ Antagonist III, G3335
Packaging: 50mg
Price: $159
Updated: 2024/03/01

Alfa Aesar

Product number: J64528
Product name: G3335
Packaging: 50mg
Price: $122
Updated: 2023/06/20

Alfa Aesar

Product number: J64528
Product name: G3335
Packaging: 100mg
Price: $208
Updated: 2023/06/20

Cayman Chemical

Product number: 17593
Product name: G3335
Purity: ≥98%
Packaging: 10mg
Price: $32
Updated: 2024/03/01

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H-TRP-GLU-OH Chemical Properties,Usage,Production

Uses

A cell-permeable dipeptide that acts as a selective and reversible peroxisome proliferator-activated receptor antagonist

Definition

ChEBI: Trp-Glu is a dipeptide formed from L-tryptophan and L-glutamic acid residues. It has a role as a metabolite.

Biological Activity

kd = 8.34 μmg3335 is a pparγ antagonist.the peroxisome proliferator-activated receptor gamma (ppargamma) is a key therapeutic drug target for several conditions, such as inflammation, diabetes, hypertension, dyslipidemia, and cancer.

in vitro

biacore 3000 study based on the surface plasmon resonance technique found that g3335 exhibited a highly specific binding affinity against ppargamma and was able to block rosiglitazone, a potent ppargamma agonist, in the stimulation of the interaction between the ppargamma ligand-binding domain (lbd) and rxralpha-lbd. moreover, the yeast two-hybrid assays indicated that g3335 had strong antagonistic activity in perturbing rosiglitazone in the promotion of the ppargamma-lbd-cbp interaction. in addition, g3335 could competitively bind to ppargamma against 0.1 microm rosiglitazone to repress reporter-gene expression [1].

in vivo

in a previous study, the effect of rosiglitazone was examined on spinal cord injury (sci) in rats. the animals were randomly divided into vehicle group, rosiglitazone treated group, and g3335 treated group. locomotor function recovery was evaluated. results showed that compared with the vehicle groups, the rosiglitazone could significantly ameliorate locomotor recovery, reduce nf-κb expression, and increase the proliferation of endogenous npcs. in addition, when the ppar-γ antagonist g3335 was applied, such effects were abolished [2].

References

[1] ye, f. ,zhang, z.s.,luo, h.b., et al. the dipeptide h-trp-glu-oh shows highly antagonistic activity against pparγ: bioassay with molecular modeling simulation. chembiochem 7, 74-82 (2006).
[2] meng, q. q.,liang, x.j.,wang, p., et al. rosiglitazone enhances the proliferation of neural progenitor cells and inhibits inflammation response after spinal cord injury. neuroscience letters 503, 191-195 (2011).

H-TRP-GLU-OH Preparation Products And Raw materials

Raw materials

Preparation Products

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H-TRP-GLU-OH Suppliers

China 66 Germany 1 Japan 1 Switzerland 2 United Kingdom 1 United States 14 Global 85

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36099-95-3, H-TRP-GLU-OHRelated Search:

Trp-Glu-OH H-GLN-TRP-GLU-OH H-TRP-ALA-OH H-DL-TRP-NH2 HCL H-ILE-ALA-ALA-ARG-ILE-VAL-GLU-LEU-LEU-GLY-ARG-ARG-GLY-TRP-GLU-OH GLYCYL-L-GLUTAMIC ACID INDOLE-3-PROPIONAMIDE H-TRP-GLU-OH GLYCYL-4-AMINO-N-BUTYRIC ACID L-Glutamic acid H-ALA-GLU-OH N-Acetyl-L-glutamic acid H-TRP-GLY-OH

TRP-GLU

H-TRP-GLU-OH

L-TRYPTOPHYL-L-GLUTAMIC ACID

L-TRP-GLU

TRP-GLU CRYSTALLINE

G3335

PPARγ Antagonist III,G3335

WE

PPARγ Antagonist III, G3335 - CAS 36099-95-3 - Calbiochem

L-Glutamic acid, L-tryptophyl-

36099-95-3

A cell-permeable dipeptide that acts as a selective and reversible PPAR./ antagonist

Amino Acid Derivatives