4-CYANO-N-METHOXY-N-METHYLBENZAMIDE
- Product Name
- 4-CYANO-N-METHOXY-N-METHYLBENZAMIDE
- CAS No.
- 116332-64-0
- Chemical Name
- 4-CYANO-N-METHOXY-N-METHYLBENZAMIDE
- Synonyms
- 4-CYANO-N-METHOXY-N-METHYLBENZAMIDE;Benzamide, 4-cyano-N-methoxy-N-methyl-;4-[Methoxy(methyl)carbamoyl]benzonitrile;4-CYANO-N-METHOXY-N-METHYLBENZENECARBOXAMIDE
- CBNumber
- CB7746132
- Molecular Formula
- C10H10N2O2
- Formula Weight
- 190.2
- MOL File
- 116332-64-0.mol
4-CYANO-N-METHOXY-N-METHYLBENZAMIDE Property
- Melting point:
- 78-80
- Boiling point:
- 383.3±25.0 °C(Predicted)
- Density
- 1.19±0.1 g/cm3(Predicted)
- storage temp.
- Sealed in dry,Room Temperature
- Appearance
- White to off-white Solid
Safety
- Hazard Codes
- Xi
- HazardClass
- IRRITANT
- HS Code
- 2928009090
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H302Harmful if swallowed
H312Harmful in contact with skin
H315Causes skin irritation
H319Causes serious eye irritation
H332Harmful if inhaled
H335May cause respiratory irritation
- Precautionary statements
-
P261Avoid breathing dust/fume/gas/mist/vapours/spray.
P264Wash hands thoroughly after handling.
P264Wash skin thouroughly after handling.
P270Do not eat, drink or smoke when using this product.
P271Use only outdoors or in a well-ventilated area.
P280Wear protective gloves/protective clothing/eye protection/face protection.
P301+P312IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.
P302+P352IF ON SKIN: wash with plenty of soap and water.
P304+P340IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
P312Call a POISON CENTER or doctor/physician if you feel unwell.
P321Specific treatment (see … on this label).
P322Specific measures (see …on this label).
P330Rinse mouth.
P332+P313IF SKIN irritation occurs: Get medical advice/attention.
P362Take off contaminated clothing and wash before reuse.
P363Wash contaminated clothing before reuse.
P501Dispose of contents/container to..…
N-Bromosuccinimide Price
- Product number
- C998535
- Product name
- 4-Cyano-N-methoxy-N-methylbenzamide
- Packaging
- 50mg
- Price
- $45
- Updated
- 2021/12/16
- Product number
- 047508
- Product name
- 4-Cyano-N-methoxy-N-methylbenzenecarboxamide
- Purity
- >95%
- Packaging
- 500mg
- Price
- $130
- Updated
- 2021/12/16
- Product number
- OR14049
- Product name
- 4-Cyano-N-methoxy-N-methylbenzamide
- Packaging
- 500mg
- Price
- $196
- Updated
- 2021/12/16
- Product number
- 047508
- Product name
- 4-Cyano-N-methoxy-N-methylbenzenecarboxamide
- Purity
- >95%
- Packaging
- 1g
- Price
- $200
- Updated
- 2021/12/16
- Product number
- 4648-1-X1
- Product name
- 4-Cyano-N-methoxy-N-methylbenzamide
- Packaging
- 500mg
- Price
- $232
- Updated
- 2021/12/16
4-CYANO-N-METHOXY-N-METHYLBENZAMIDE Chemical Properties,Usage,Production
Synthesis
6638-79-5
6068-72-0
116332-64-0
Synthesis was carried out using the method of Faul et al. To a suspension of acetonitrile (100 mL) and water (50 mL) containing N,O-dimethylhydroxylamine hydrochloride (7.07 g, 72.5 mmol) and K2CO3 (10.0 g, 72.5 mmol), 4-cyanobenzoyl chloride (8.00 g, 48.3 mmol) was slowly added. The reaction mixture was stirred at room temperature for 2 hours. Upon completion of the reaction, the solution was poured into water (50 mL) and extracted with ethyl acetate. The organic layers were combined, washed with brine, dried over anhydrous sodium sulfate and concentrated under reduced pressure to give the crude product. The crude product was purified by silica gel column chromatography (250 mL of silica gel, eluent ratio tapered from hexane:ethyl acetate 45:55 to 1:1) to afford N-methoxy-N-methyl-4-cyanobenzamide (8.12 g, 88% yield) as a white crystalline solid. The product was characterized as follows: 1H NMR (400 MHz, CDCl3) δ 7.76 (d, J = 8.4 Hz, 2H), 7.69 (d, J = 8.4 Hz, 2H), 3.50 (s, 3H), 3.36 (s, 3H); 13C NMR (100.6 MHz, CDCl3) δ 167.8, 138.2, 131.8, 128.7, 118.1, 114.0, 61.2, 33.0; GC-MS (M)+ calculated value C10H10N2O2 190.0742, measured value 190.0739.
References
[1] Patent: WO2013/40227, 2013, A2. Location in patent: Page/Page column 27; 28
[2] Journal of Medicinal Chemistry, 2013, vol. 56, # 21, p. 8432 - 8454
[3] Journal of Organic Chemistry, 2001, vol. 66, # 17, p. 5772 - 5782
[4] Journal of Medicinal Chemistry, 2008, vol. 51, # 19, p. 6138 - 6149
[5] Journal of Organic Chemistry, 2003, vol. 68, # 14, p. 5500 - 5511
4-CYANO-N-METHOXY-N-METHYLBENZAMIDE Preparation Products And Raw materials
Raw materials
Preparation Products
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