4,N-DIMETHYL-N-METHOXYBENZAMIDE

Product Name: 4,N-DIMETHYL-N-METHOXYBENZAMIDE
CAS No.: 122334-36-5
Chemical Name: 4,N-DIMETHYL-N-METHOXYBENZAMIDE
Synonyms: N-methoxy-N,4-dimethylbenzamide;N,4-DIMETHOXY-N-METHYLBENZAMIDE;4,N-DIMETHYL-N-METHOXYBENZAMIDE;Benzamide, N-methoxy-N,4-dimethyl-
CBNumber: CB2377001
Molecular Formula: C10H13NO2
Formula Weight: 179.22
MOL File: 122334-36-5.mol

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4,N-DIMETHYL-N-METHOXYBENZAMIDE Property

Boiling point:: 318.4±21.0 °C(Predicted)
Density: 1.070±0.06 g/cm3(Predicted)
refractive index: 1.53
storage temp.: Sealed in dry,Room Temperature
form: clear liquid
color: Colorless to Almost colorless

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Safety

HS Code: 2928009090

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H315Causes skin irritation

H319Causes serious eye irritation

Precautionary statements

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P302+P352IF ON SKIN: wash with plenty of soap and water.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

P332+P313IF SKIN irritation occurs: Get medical advice/attention.

P337+P313IF eye irritation persists: Get medical advice/attention.

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N-Bromosuccinimide Price

TCI Chemical

Product number: M3098
Product name: N-Methoxy-N,4-dimethylbenzamide
Packaging: 1G
Price: $45
Updated: 2025/07/31

TCI Chemical

Product number: M3098
Product name: N-Methoxy-N,4-dimethylbenzamide
Packaging: 5G
Price: $228
Updated: 2025/07/31

AK Scientific

Product number: 4243AA
Product name: N-Methoxy-N,4-dimethylbenzamide
Packaging: 250mg
Price: $123
Updated: 2021/12/16

American Custom Chemicals Corporation

Product number: CHM0025046
Product name: 4,N-DIMETHYL-N-METHOXYBENZAMIDE
Purity: 95.00%
Packaging: 10G
Price: $1334.03
Updated: 2021/12/16

Chemenu

Product number: CM248315
Product name: N-Methoxy-N,4-dimethylbenzamide
Purity: 95%
Packaging: 1g
Price: $138
Updated: 2021/12/16

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4,N-DIMETHYL-N-METHOXYBENZAMIDE Chemical Properties,Usage,Production

Uses

N-Methoxy-N,4-dimethylbenzamide is used in the synthesis of Fingolimod (F342045)

Synthesis

99-94-5

1117-97-1

122334-36-5

GENERAL PROCEDURE: Methoxymethylamine (0.360 g, 6.0 mmol) and p-methylbenzoic acid (0.244 g, 2.0 mmol) were dissolved in anhydrous toluene (10 mL) and stirred for 10 min at 0 °C. Subsequently, a solution of phosphorus trichloride (0.137 g, 1.0 mmol) in anhydrous toluene (2 mL) was slowly added dropwise to the above mixture. The reaction mixture was gradually warmed up to room temperature, followed by stirring at 60 °C for 0.5 hours. The progress of the reaction was monitored by thin layer chromatography (TLC) and after confirming the completion of the reaction, the mixture was cooled to room temperature. The reaction was quenched with saturated sodium bicarbonate solution (20 mL) and extracted with ethyl acetate (3 x 10 mL). The organic layers were combined and dried over anhydrous magnesium sulfate. The solvent was removed by concentration under reduced pressure and the resulting crude product was purified by column chromatography (silica gel, petroleum ether-ethyl acetate, 3:2) to afford the colorless oily target product N-methoxy-N,4-dimethylbenzamide (320 mg, 97% yield).

References

[1] Synthesis (Germany), 2014, vol. 46, # 3, p. 320 - 330
[2] Organic Letters, 2000, vol. 2, # 25, p. 4091 - 4093
[3] Chimia, 1995, vol. 49, # 10, p. 381 - 385

4,N-DIMETHYL-N-METHOXYBENZAMIDE Preparation Products And Raw materials

Raw materials

Preparation Products

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4,N-DIMETHYL-N-METHOXYBENZAMIDE Suppliers

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122334-36-5, 4,N-DIMETHYL-N-METHOXYBENZAMIDERelated Search:

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4,N-DIMETHYL-N-METHOXYBENZAMIDE

N,4-DIMETHOXY-N-METHYLBENZAMIDE

N-methoxy-N,4-dimethylbenzamide

Benzamide, N-methoxy-N,4-dimethyl-

122334-36-5