ATROPINE METHYL NITRATE

Product Name: ATROPINE METHYL NITRATE
CAS No.: 52-88-0
Chemical Name: ATROPINE METHYL NITRATE
Synonyms: D01077;ekomine;europen;eumydrin;metanite;metropine;eumidrina;eumydrine;harvatrate;Ekomine (tn)
CBNumber: CB7747265
Molecular Formula: C18H26N2O6
Formula Weight: 366.41
MOL File: 52-88-0.mol

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ATROPINE METHYL NITRATE Property

Melting point:: 163°C
storage temp.: -20°C
solubility: H₂O: 50 mg/mL
form: powder
color: white
Merck: 875
CAS DataBase Reference: 52-88-0(CAS DataBase Reference)
EPA Substance Registry System: Methylatropine nitrate (52-88-0)

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Safety

Hazard Codes: Xn,T+
Risk Statements: 22-26/28
Safety Statements: 22-36-45-25
RIDADR: 1544
WGK Germany: 3
RTECS: CK2800000
Toxicity: LD50 oral in rat: 1902mg/kg

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Danger

Precautionary statements

P260Do not breathe dust/fume/gas/mist/vapours/spray.

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P284Wear respiratory protection.

P301+P310IF SWALLOWED: Immediately call a POISON CENTER or doctor/physician.

P310Immediately call a POISON CENTER or doctor/physician.

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N-Bromosuccinimide Price

American Custom Chemicals Corporation

Product number: CHM0013737
Product name: ATROPINE METHYL NITRATE
Purity: 95.00%
Packaging: 10G
Price: $2555.27
Updated: 2021/12/16

Chemtos

Product number: A-7536
Product name: Atropinemethylnitrate(AMN)
Packaging: 50mg
Price: $1990
Updated: 2021/12/16

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ATROPINE METHYL NITRATE Chemical Properties,Usage,Production

Chemical Properties

mp 162-164 C

Originator

Methylatropine,Paganfarma

Uses

Atropine methyl nitrate has been used to suppress mucus production and respiratory secretions in rats. It has also been used to study its effects on xanomeline-induced suppression of serum tumor necrosis factor.

Uses

antibacterial

Uses

cephalosporin antimicrobial

Manufacturing Process

There are 2 methods of synthesis of methyl atropine nitrate:
1) To a solution of 28.9 g atropine of in 100 g of methanol was added at 110°C for 2 hours 7.7 g methyl nitrate. Methanol was evaporated and methyl atropine nitrate was crystallysed, M.P. 163°C.
2) To a solution of 70.4 g methyl atropine sulfate (prepared from methyl atropine chloride and silver nitrate) in water was added aqueous solution of 26.1 g barium nitrate. Barium sulfate was deleted by filtration. Filtrate was concentrated and the methyl atropine nitrate was obtained.

brand name

Ekomine (Hoechst-Roussel); Eumydrin (Sterling Winthrop).

Therapeutic Function

Anticholinergic, Mydriatic, Spasmolytic

Biochem/physiol Actions

Atropine methyl nitrate is a muscarinic acetylcholine receptor antagonist that does not cross the blood brain barrier. Atropine methyl nitrate has been used for its peripheral muscarinic effects (bladder, respiratory, to block parasympathetic signaling to the heart, etc.) and to separate central from peripheral effects or protect against peripheral side effects when using muscarinics that do cross the blood brain barrier.

Safety Profile

Poison by intraperitoneal, intravenous, and subcutaneous routes. Moderately toxic by ingestion. Human systemic effects: mydriasis. Experimental reproductive effects. When heated to decomposition it emits toxic fumes of NOx. See also ATROPINE and NITRATES.

ATROPINE METHYL NITRATE Preparation Products And Raw materials

Raw materials

Preparation Products

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ATROPINE METHYL NITRATE Suppliers

China 22 China Hong Kong 1 France 1 Germany 2 India 2 Switzerland 1 United Kingdom 3 United States 12 Global 44

TargetMol Chemicals Inc.

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MP Biomedicals, Inc.

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City Chemicals Corporation

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52-88-0, ATROPINE METHYL NITRATERelated Search:

HEPTYL ISOBUTYRATE 6-DIMETHYLAMINO-1-HEXANOL PETIOLE Atropine 4-PROPOXY-PIPERIDINE ATROPINE METHYL NITRATE FEMA 3457 Cycloheptanol SCOPOLAMINE METHYL NITRATE AMYL PHENYLACETATE 1-Methyl-2-pyrrolidineethanol ISOPROPYL PHENYLACETATE 8-METHYL-8-AZABICYCLO[3.2.1]OCTANE 2-Phenyl-1,3-propanediol Tetramethylammonium nitrate A-(HYDROXYMETHYL)BENZENACETIC ACID METHYL ESTER Nortropine hydrochloride Methylamine nitrate

metropine

n-methylatropinenitrate

N-METHYLATROPINIUM NITRATE

,endo-(+/-)-,nitrate(salt)

1-alpha-h,5-alpha-h-tropanium,3-alpha-hydroxy-8-methyl-,nitrate,(+-)-tropa

3-alpha-hydroxy-8-methyl-1-alpha-h,5-alpha-h-tropaniumbromide(+,-)-tropate

8-methylatropiniumnitrate

8-methyl-atropiniunitrate

dl-hyoscyaminemethylnitrate

dl-hyosyaminemethylnitrate

ekomine

eumidrina

eumydrin

eumydrine

europen

harvatrate

metanite

ATROPINE METHYL NITRATE

ATROPINE METHONITRATE

Atropinmethonitrat

AMN, Methylatropine nitrate

methylatropinenitrate

Atropine methonitrate (jan/inn)

D01077

Ekomine (tn)

Methylatropine nitrate (usan)

ATROPINE METHYL NITRATE(P)

ATROPINE METHYL NITRATE(SH)

Atropine methyl nitrate 99.5%

(8,8-dimethyl-8-azoniabicyclo[3.2.1]octan-3-yl)3-hydroxy-2-phenylpropanoate,nitrate

52-88-0

C18H26NO3NO3

Tropane Alkaloids

Alkaloids

Biochemistry

Tropane Alkaloids