REBECCAMYCIN

Product Name: REBECCAMYCIN
CAS No.: 93908-02-2
Chemical Name: REBECCAMYCIN
Synonyms: NSC 359079;chrysomycin;REBECCAMYCIN;Rebeccamycin, Antibiotic agent;dro-12-(4-o-methyl-beta-d-glucopyranosyl)-;REBECCAMYCIN, SACCHAROTHRIX AEROCOLONIGENES;5h-indolo(2,3-a)pyrrolo(3,4-c)carbazole-5,7(6h)-dione,1,11-dichloro-12,13-dihy;1,11-Dichloro-12,13-dihydro-12-(4-O-methyl-β-D-glucopyranosyl)-5H-indolo[2,3-a]pyrrolo[3,4-c]carbazole-5,7(6H)-dione;5H-Indolo[2,3-a]pyrrolo[3,4-c]carbazole-5,7(6H)-dione, 1,11-dichloro-12,13-dihydro-12-(4-O-methyl-β-D-glucopyranosyl)-;7,10-Dichloro-8-(3,4-dihydroxy-6-(hydroxymethyl)-5-methoxytetrahydro-2H-pyran-2-yl)-8,9-dihydro-1H-indolo[2,3-a]pyrrolo[3,4-c]carbazole-1,3(2H)-dione
CBNumber: CB7747508
Molecular Formula: C27H21Cl2N3O7
Formula Weight: 570.38
MOL File: 93908-02-2.mol

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REBECCAMYCIN Property

storage temp.: −20°C
solubility: DMSO: ≥3 mg/mL
form: solid
color: yellow

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Safety

WGK Germany: -

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Hazard and Precautionary Statements (GHS)

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N-Bromosuccinimide Price

Cayman Chemical

Product number: 17914
Product name: Rebeccamycin
Purity: ≥99%
Packaging: 500μg
Price: $178
Updated: 2024/03/01

Cayman Chemical

Product number: 17914
Product name: Rebeccamycin
Purity: ≥99%
Packaging: 2.5mg
Price: $793
Updated: 2024/03/01

TRC

Product number: R140000
Product name: Rebeccamycin
Packaging: 0.5mg
Price: $125
Updated: 2021/12/16

Usbiological

Product number: 207378
Product name: Rebeccamycin
Packaging: 250ug
Price: $337
Updated: 2021/12/16

Usbiological

Product number: R1281-15
Product name: Rebeccamycin
Packaging: 500ug
Price: $482
Updated: 2021/12/16

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REBECCAMYCIN Chemical Properties,Usage,Production

Uses

Rebeccamycin is an indolocarbazole isolated from Lechevalieria aerocolonigenes. Rebeccamycin displays selective antitumour activity against several cell lines. Rebeccamycin's primary mechanism of action is via strong DNA intercalation resulting in the potent catalytic inhibition of both topoisomerases I and II. Analogues of rebecamycin have beend tested in clinical trials for cancer therapy.

Uses

Rebeccamycin is a novel indolocarbazole topoisomerase I inhibitor.

Definition

ChEBI: An N-glycosyl compound consisting of a heteropolycyclic ring system with a glucosyl group attached to one of the indolic nitrogens.

in vivo

Rebeccamycin (2-256 mg/kg; i.p.; daily for 9 days) prolongs survival in B16 melanoma, L1210 leukemia^[2].

Animal Model:	CDF1 mice (B16 melanoma, L1210 leukemia)^[2]
Dosage:	2, 4, 8, 16, 32, 64, 128, 256 mg/kg
Administration:	I.p.; daily for 9 days
Result:	Prolongation of survival of the mice at dose levels ranging from 8 to 256 mg/kg.

IC 50

Topoisomerase I; Traditional Cytotoxic Agents

storage

+4°C

REBECCAMYCIN Preparation Products And Raw materials

Raw materials

Preparation Products

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REBECCAMYCIN Suppliers

China 50 Germany 1 India 1 Switzerland 2 United Kingdom 2 United States 12 Global 68

Shanghai Tauto Biotech Co., Ltd.

Tel: 021-51320588
Fax: 0086-21-51320502
Email: tauto@tautobiotech.com
Country: China
ProdList: 3989
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Guangzhou Isun Pharmaceutical Co., Ltd

Tel: 020-39119399 18927568969
Fax: 020-39119999
Email: isunpharm@qq.com
Country: China
ProdList: 4720
Advantage: 55

ChemStrong Scientific Co.,Ltd

Tel: 0755-0755-66853366 13670046396
Fax: 0755-28363542
Email: sales@chem-strong.com
Country: China
ProdList: 18146
Advantage: 56

Shanghai EFE Biological Technology Co., Ltd.

Tel: 021-65675885 18964387627
Fax: 021-65675885
Email: info@efebio.com
Country: China
ProdList: 9803
Advantage: 58

Beijing Jin Ming Biotechnology Co., Ltd.

Tel: 010-60605840 18892239720
Fax: 010-60605840
Email: psaitong@jm-bio.com
Country: China
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Advantage: 58

Lynnchem

Tel: 86-(0)29-85992781 17792393971
Email: info@lynnchem.com
Country: China
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Novachemistry

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Shanghai Hongye Biotechnology Co. Ltd

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Country: China
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Shenzhen Polymeri Biochemical Technology Co., Ltd.

Tel: +86-400-002-6226 +86-13028896684;
Email: sales@rrkchem.com
Country: China
ProdList: 57422
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TargetMol Chemicals Inc.

Tel: +1-781-999-5354 +1-00000000000
Email: marketing@targetmol.com
Country: United States
ProdList: 32159
Advantage: 58

93908-02-2, REBECCAMYCINRelated Search:

((1E,3E)-4-CHLORO-BUTA-1,3-DIENYL)-BENZENE 1-Chloro-3-isopropoxypropane 1,4-DIISOPROPENYLBENZENE 4-N-OCTYLSTYRENE 1-PHENYL-1-CYCLOHEXENE 3-METHYL-3-CYCLOHEXEN-1-ONE REBECCAMYCIN 2,4,5-TRIMETHYLANILINEHYDROCHLORIDE 2,5-Dimethylbenzyl chloride

5h-indolo(2,3-a)pyrrolo(3,4-c)carbazole-5,7(6h)-dione,1,11-dichloro-12,13-dihy

dro-12-(4-o-methyl-beta-d-glucopyranosyl)-

REBECCAMYCIN

REBECCAMYCIN, SACCHAROTHRIX AEROCOLONIGENES

1,11-Dichloro-12,13-dihydro-12-(4-O-methyl-β-D-glucopyranosyl)-5H-indolo[2,3-a]pyrrolo[3,4-c]carbazole-5,7(6H)-dione

NSC 359079

7,10-Dichloro-8-(3,4-dihydroxy-6-(hydroxymethyl)-5-methoxytetrahydro-2H-pyran-2-yl)-8,9-dihydro-1H-indolo[2,3-a]pyrrolo[3,4-c]carbazole-1,3(2H)-dione

5H-Indolo[2,3-a]pyrrolo[3,4-c]carbazole-5,7(6H)-dione, 1,11-dichloro-12,13-dihydro-12-(4-O-methyl-β-D-glucopyranosyl)-

chrysomycin

Rebeccamycin, Antibiotic agent

93908-02-2

C27H21Cl2N3O7

BioChemical

Antibiotics A to Z

Antibiotics

Antibiotics N-S