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REBECCAMYCIN

Product Name
REBECCAMYCIN
CAS No.
93908-02-2
Chemical Name
REBECCAMYCIN
Synonyms
NSC 359079;chrysomycin;REBECCAMYCIN;Rebeccamycin, Antibiotic agent;dro-12-(4-o-methyl-beta-d-glucopyranosyl)-;REBECCAMYCIN, SACCHAROTHRIX AEROCOLONIGENES;5h-indolo(2,3-a)pyrrolo(3,4-c)carbazole-5,7(6h)-dione,1,11-dichloro-12,13-dihy;1,11-Dichloro-12,13-dihydro-12-(4-O-methyl-β-D-glucopyranosyl)-5H-indolo[2,3-a]pyrrolo[3,4-c]carbazole-5,7(6H)-dione;5H-Indolo[2,3-a]pyrrolo[3,4-c]carbazole-5,7(6H)-dione, 1,11-dichloro-12,13-dihydro-12-(4-O-methyl-β-D-glucopyranosyl)-;7,10-Dichloro-8-(3,4-dihydroxy-6-(hydroxymethyl)-5-methoxytetrahydro-2H-pyran-2-yl)-8,9-dihydro-1H-indolo[2,3-a]pyrrolo[3,4-c]carbazole-1,3(2H)-dione
CBNumber
CB7747508
Molecular Formula
C27H21Cl2N3O7
Formula Weight
570.38
MOL File
93908-02-2.mol
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REBECCAMYCIN Property

storage temp. 
−20°C
solubility 
DMSO: ≥3 mg/mL
form 
solid
color 
yellow
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Safety

WGK Germany 
-
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Hazard and Precautionary Statements (GHS)

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N-Bromosuccinimide Price

Cayman Chemical
Product number
17914
Product name
Rebeccamycin
Purity
≥99%
Packaging
500μg
Price
$178
Updated
2024/03/01
Cayman Chemical
Product number
17914
Product name
Rebeccamycin
Purity
≥99%
Packaging
2.5mg
Price
$793
Updated
2024/03/01
TRC
Product number
R140000
Product name
Rebeccamycin
Packaging
0.5mg
Price
$125
Updated
2021/12/16
Usbiological
Product number
207378
Product name
Rebeccamycin
Packaging
250ug
Price
$337
Updated
2021/12/16
Usbiological
Product number
R1281-15
Product name
Rebeccamycin
Packaging
500ug
Price
$482
Updated
2021/12/16
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REBECCAMYCIN Chemical Properties,Usage,Production

Uses

Rebeccamycin is an indolocarbazole isolated from Lechevalieria aerocolonigenes. Rebeccamycin displays selective antitumour activity against several cell lines. Rebeccamycin's primary mechanism of action is via strong DNA intercalation resulting in the potent catalytic inhibition of both topoisomerases I and II. Analogues of rebecamycin have beend tested in clinical trials for cancer therapy.

Uses

Rebeccamycin is a novel indolocarbazole topoisomerase I inhibitor.

Definition

ChEBI: An N-glycosyl compound consisting of a heteropolycyclic ring system with a glucosyl group attached to one of the indolic nitrogens.

in vivo

Rebeccamycin (2-256 mg/kg; i.p.; daily for 9 days) prolongs survival in B16 melanoma, L1210 leukemia[2].

Animal Model:CDF1 mice (B16 melanoma, L1210 leukemia)[2]
Dosage:2, 4, 8, 16, 32, 64, 128, 256 mg/kg
Administration:I.p.; daily for 9 days
Result:Prolongation of survival of the mice at dose levels ranging from 8 to 256 mg/kg.

IC 50

Topoisomerase I; Traditional Cytotoxic Agents

storage

+4°C

REBECCAMYCIN Preparation Products And Raw materials

Raw materials

Preparation Products

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REBECCAMYCIN Suppliers

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93908-02-2, REBECCAMYCINRelated Search:

((1E,3E)-4-CHLORO-BUTA-1,3-DIENYL)-BENZENE 1-Chloro-3-isopropoxypropane 1,4-DIISOPROPENYLBENZENE 4-N-OCTYLSTYRENE 1-PHENYL-1-CYCLOHEXENE 3-METHYL-3-CYCLOHEXEN-1-ONE REBECCAMYCIN 2,4,5-TRIMETHYLANILINEHYDROCHLORIDE 2,5-Dimethylbenzyl chloride

  • 5h-indolo(2,3-a)pyrrolo(3,4-c)carbazole-5,7(6h)-dione,1,11-dichloro-12,13-dihy
  • dro-12-(4-o-methyl-beta-d-glucopyranosyl)-
  • REBECCAMYCIN
  • REBECCAMYCIN, SACCHAROTHRIX AEROCOLONIGENES
  • 1,11-Dichloro-12,13-dihydro-12-(4-O-methyl-β-D-glucopyranosyl)-5H-indolo[2,3-a]pyrrolo[3,4-c]carbazole-5,7(6H)-dione
  • NSC 359079
  • 7,10-Dichloro-8-(3,4-dihydroxy-6-(hydroxymethyl)-5-methoxytetrahydro-2H-pyran-2-yl)-8,9-dihydro-1H-indolo[2,3-a]pyrrolo[3,4-c]carbazole-1,3(2H)-dione
  • 5H-Indolo[2,3-a]pyrrolo[3,4-c]carbazole-5,7(6H)-dione, 1,11-dichloro-12,13-dihydro-12-(4-O-methyl-β-D-glucopyranosyl)-
  • chrysomycin
  • Rebeccamycin, Antibiotic agent
  • 93908-02-2
  • C27H21Cl2N3O7
  • BioChemical
  • Antibiotics A to Z
  • Antibiotics
  • Antibiotics N-S