N-METHYL MESOPORPHYRIN IX
- Product Name
- N-METHYL MESOPORPHYRIN IX
- CAS No.
- 142234-85-3
- Chemical Name
- N-METHYL MESOPORPHYRIN IX
- Synonyms
- N-METHYL MESOPORPHYRIN IX;8,13-Diethyl-3,7,12,17,23-pentamethyl-21H,23H-porphine-2,18-dipropanoic acid;21H,23H-Porphine-2,18-dipropanoic acid, 8,13-diethyl-3,7,12,17,23-pentamethyl-;3,3'-(8,13-Diethyl-3,7,12,17,23-pentamethylporphyrin-2,18-diyl)dipropionic acid;21H,23H-Porphine-2,18-dipropanoic acid, 8,13-diethyl-3,7,12,17,23-pentamethyl- (9ci);3-[20-(2-carboxyethyl)-10,15-diethyl-5,9,14,19,22-pentamethyl-21,22,23,24-tetraazapentacyclo[16.2.1.13,?.1?,11.113,1?]tetracosa-1,3,5,7,9,11(23),12,14,16,18(21),19-undecaen-4-yl]propanoic acid
- CBNumber
- CB7749087
- Molecular Formula
- C35H40N4O4
- Formula Weight
- 580.72
- MOL File
- Mol file
N-METHYL MESOPORPHYRIN IX Property
- Density
- 1.26±0.1 g/cm3(Predicted)
- storage temp.
- Store at -20°C
- solubility
- DMF: 20 mg/ml; DMF:PBS (pH 7.2) (1:5): 0.17 mg/ml; DMSO: 15 mg/ml
- form
- A crystalline solid
- color
- Brown to black
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H315Causes skin irritation
H319Causes serious eye irritation
H335May cause respiratory irritation
- Precautionary statements
-
P264Wash hands thoroughly after handling.
P264Wash skin thouroughly after handling.
P280Wear protective gloves/protective clothing/eye protection/face protection.
P302+P352IF ON SKIN: wash with plenty of soap and water.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
P321Specific treatment (see … on this label).
P332+P313IF SKIN irritation occurs: Get medical advice/attention.
P362Take off contaminated clothing and wash before reuse.
N-Bromosuccinimide Price
- Product number
- 27210
- Product name
- N-methyl Mesoporphyrin IX
- Packaging
- 1mg
- Price
- $93
- Updated
- 2024/03/01
- Product number
- 27210
- Product name
- N-methyl Mesoporphyrin IX
- Packaging
- 5mg
- Price
- $208
- Updated
- 2024/03/01
N-METHYL MESOPORPHYRIN IX Chemical Properties,Usage,Production
Uses
N-Methylmesoporphyrin IX (NMM), a widely used G-quadruplex DNA specific fluorescent binder, is an efficient probe for monitoring Aβ fibrillation. N-Methylmesoporphyrin IX is an in situ inhibitor and an ex situ monitor for Aβ amyloidogenesis both in vitro and in cells. N-Methylmesoporphyrin IX is sensitive to G-quadruplexes DNA but has no response to duplexes, triplexes and single-stranded forms DNA. N-Methylmesoporphyrin IX is nonfluorescent alone or in monomeric Aβ environments, but emits strong fluorescence through stacking with the Aβ assemblies[1].
References
[1] Meng Li, et al. N-Methyl Mesoporphyrin IX as an Effective Probe for Monitoring Alzheimer's Disease β-Amyloid Aggregation in Living Cells. ACS Chem Neurosci. 2017 Jun 21;8(6):1299-1304. DOI:10.1021/acschemneuro.6b00436