4-N-Cbz-cyclohexanone

Application

Product Name: 4-N-Cbz-cyclohexanone
CAS No.: 16801-63-1
Chemical Name: 4-N-Cbz-cyclohexanone
Synonyms: Benzyl 4-oxocyclohexylcarbamate;(4-Oxo-cyclo;N-Cbz-4-aminocycL;4-N-CBZ-CYCLOHEXANONE;4-(Cbz-aMino)cyclohexanone;4-N-CBZ-AMINO-CYCLOHEXANONE;N-CBZ-4-AMINO-CYCLOHEXANONE;Benzyl-4-oxo-N-cyclohexylcarbamat;N-Cbz-4-aminocyclohexanone;4-CARBOBENZOXY-AMINO-CYCLOHEXANONE
CBNumber: CB7751473
Molecular Formula: C14H17NO3
Formula Weight: 247.29
MOL File: 16801-63-1.mol

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4-N-Cbz-cyclohexanone Property

Melting point:: 86-87°C
Boiling point:: 427.3±44.0 °C(Predicted)
Density: 1.17±0.1 g/cm3(Predicted)
storage temp.: Inert atmosphere,Room Temperature
form: solid
pka: 11.98±0.20(Predicted)
Appearance: White to off-white Solid
InChI: InChI=1S/C14H17NO3/c16-13-8-6-12(7-9-13)15-14(17)18-10-11-4-2-1-3-5-11/h1-5,12H,6-10H2,(H,15,17)
InChIKey: VHXBIBFCJISKFA-UHFFFAOYSA-N
SMILES: C(OCC1=CC=CC=C1)(=O)NC1CCC(=O)CC1
CAS DataBase Reference: 16801-63-1(CAS DataBase Reference)

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Safety

Hazard Codes: Xi
Risk Statements: 36
Safety Statements: 26
WGK Germany: 3
HazardClass: IRRITANT
HS Code: 29242990

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word: Warning
Hazard statements: H319Causes serious eye irritation
Precautionary statements: P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

Sigma-Aldrich

Product number: 694541
Product name: N-Cbz-4-aminocyclohexanone
Purity: 97%
Packaging: 5g
Price: $86.5
Updated: 2025/07/31

Sigma-Aldrich

Product number: 694541
Product name: N-Cbz-4-aminocyclohexanone
Purity: 97%
Packaging: 1g
Price: $51
Updated: 2023/06/20

TRC

Product number: O990045
Product name: (4-Oxocyclohexyl)carbamicAcidBenzylEster
Packaging: 10mg
Price: $45
Updated: 2021/12/16

Matrix Scientific

Product number: 020566
Product name: 4-N-Cbz-cyclohexanone
Purity: 97%
Packaging: 5g
Price: $49
Updated: 2021/12/16

AK Scientific

Product number: B171
Product name: 4-(Benzyloxycarbonylamino)cyclohexanone
Packaging: 5g
Price: $54
Updated: 2021/12/16

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4-N-Cbz-cyclohexanone Chemical Properties,Usage,Production

Application

4-N-Benzyloxycarbonylaminocyclohexanone can be used as an organic synthesis intermediate and a pharmaceutical intermediate in laboratory research and development as well as in chemical production synthesis.

Synthesis

27489-63-0

16801-63-1

General procedure for the synthesis of 4-N-benzyloxycarbonylaminocyclohexanone from benzyl (trans-4-hydroxycyclohexyl)carbamate: synthesis of compound 120.3. Jones reagent (~10 mL) was added slowly and dropwise to a solution of compound 120.2 (7.0 g, 28.08 mmol, 1.00 eq.) in acetone (100 mL) at 0 °C. The reaction process was monitored by thin layer chromatography (TLC). After stirring the reaction mixture for 30 minutes, the reaction was quenched with saturated aqueous sodium bisulfite (NaHSO3) solution. Subsequently, extraction was performed with ethyl acetate (EtOAc, 3 x 100 mL). The organic layers were combined, washed with saturated aqueous sodium chloride (NaCl), dried over anhydrous sodium sulfate (Na2SO4), and finally concentrated under reduced pressure to give 5.0 g (72% yield) of compound 120.3 as a white solid.

References

[1] Journal of Organic Chemistry, 2012, vol. 77, # 6, p. 3005 - 3009
[2] Bioorganic and Medicinal Chemistry, 2010, vol. 18, # 10, p. 3387 - 3402
[3] Synthetic Communications, 1990, vol. 20, # 7, p. 1073 - 1082
[4] Patent: WO2014/194242, 2014, A2. Location in patent: Paragraph 00693; 00695
[5] Patent: WO2015/164374, 2015, A1. Location in patent: Paragraph 00288; 00290

4-N-Cbz-cyclohexanone Preparation Products And Raw materials

Raw materials

Preparation Products

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4-N-Cbz-cyclohexanone Suppliers

Canada 2 China 134 France 1 Germany 1 India 4 Japan 1 Switzerland 1 United Kingdom 10 United States 31 Global 185

Beijing Bosennuokang Pharmaceutical Technology Co., Ltd.

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J & K SCIENTIFIC LTD.

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Energy Chemical

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Shanghai Hanhong Scientific Co.,Ltd.

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Chembon Pharmaceutical Co., Ltd.

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Fax: +86-28-84252965
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View Lastest Price from 4-N-Cbz-cyclohexanone manufacturers

Zhuozhou Wenxi import and Export Co., Ltd

Product: 4-N-Cbz-cyclohexanone 16801-63-1
Price: US $15.00-10.00/KG
Min. Order: 1KG
Purity: 99%+ HPLC
Supply Ability: Monthly supply of 1 ton
Release date: 2021-06-27

Career Henan Chemical Co

Product: 4-N-Cbz-amino-cyclohexanone 16801-63-1
Price: US $3.00/KG
Min. Order: 1KG
Purity: 99%
Supply Ability: 100kg
Release date: 2019-08-07

16801-63-1, 4-N-Cbz-cyclohexanoneRelated Search:

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16801-63-1

pharmacetical

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