6,7-Dihydro-4(5H)-benzofuranone

Product Name: 6,7-Dihydro-4(5H)-benzofuranone
CAS No.: 16806-93-2
Chemical Name: 6,7-Dihydro-4(5H)-benzofuranone
Synonyms: 6,7-dihydrobenzofuran-4(5H)-one;6,7-Dihydro-4(5H)-be;7-Dihydro-4(5H)-benzofuranone;2,3-Dihydro-4(5H)-benzofuranone;6,7-DIHYDRO-4(5H)-BENZOFURANONE;6,7-dihydro-5H-benzofuran-4-one;4(5H)-Benzofuranone,6,7-dihydro-;6,7-dihydro-5H-1-benzofuran-4-one;6,7-DIHYDRO-1-BENZOFURAN-4(5H)-ONE;4-oxo-4,5,6,7-tetrahydrobenzofuran
CBNumber: CB7753154
Molecular Formula: C8H8O2
Formula Weight: 136.15
MOL File: 16806-93-2.mol

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6,7-Dihydro-4(5H)-benzofuranone Property

Melting point:: 30-34 °C (lit.)
Boiling point:: 115-118 °C/16 mmHg (lit.)
Density: 1.162 g/mL at 25 °C (lit.)
refractive index: 1.53-1.532
Flash point:: >230 °F
storage temp.: Sealed in dry,Store in freezer, under -20°C
form: Liquid
Specific Gravity: 1.162
color: Clear yellow to brown
InChI: InChI=1S/C8H8O2/c9-7-2-1-3-8-6(7)4-5-10-8/h4-5H,1-3H2
InChIKey: DXWQOYPYNPSVRL-UHFFFAOYSA-N
SMILES: O1C2CCCC(=O)C=2C=C1
CAS DataBase Reference: 16806-93-2(CAS DataBase Reference)

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Safety

Hazard Codes: Xi
Risk Statements: 36/37/38
Safety Statements: 37/39-26
WGK Germany: 3
HS Code: 29143900

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

Sigma-Aldrich

Product number: 476773
Product name: 6,7-Dihydro-4(5H)-benzofuranone
Purity: 98%
Packaging: 5g
Price: $149
Updated: 2023/06/20

TRC

Product number: D452065
Product name: 6,7-Dihydro-4(5H)-benzofuranone
Packaging: 10mg
Price: $45
Updated: 2021/12/16

Ark Pharm

Product number: AK-63547
Product name: 6,7-Dihydrobenzofuran-4(5H)-one
Purity: 98%
Packaging: 250mg
Price: $7
Updated: 2021/12/16

Biosynth Carbosynth

Product number: FD02000
Product name: 6,7-Dihydro-4(5H)-benzofuranone
Packaging: 2g
Price: $66
Updated: 2021/12/16

Biosynth Carbosynth

Product number: FD02000
Product name: 6,7-Dihydro-4(5H)-benzofuranone
Packaging: 5G
Price: $125
Updated: 2021/12/16

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6,7-Dihydro-4(5H)-benzofuranone Chemical Properties,Usage,Production

Chemical Properties

clear yellow to brown low melting solid or liquid

Uses

6,7-Dihydro-4(5H)-benzofuranone may be used in the synthesis of furacridone ring skeleton.

Definition

ChEBI: 6,7-Dihydro-4(5H)-benzofuranone is a member of benzofurans.

Synthesis Reference(s)

Tetrahedron, 51, p. 3087, 1995 DOI: 10.1016/0040-4020(95)00070-O
Tetrahedron Letters, 27, p. 1127, 1986 DOI: 10.1016/S0040-4039(00)84195-7

General Description

6,7-Dihydro-4(5H)-benzofuranone is a benzofuran derivative that consists of fused benzene and furan ring. Its standard molar enthalpy of formation by static bomb calorimetry and standard molar enthalpy of vaporization using Calvet microcalorimetry has been measured. These values have been used to derive the standard molar enthalpy of formation in gaseous phase.

Synthesis

107-20-0

504-02-9

16806-93-2

Under argon protection, 1,3-cyclohexanedione (20.71 g, 0.18 mol) was dissolved in methanol (100 mL) and the solution was cooled to 0 °C. Subsequently, potassium hydroxide (12.2 g, 0.18 mol) was added to the solution and stirred continuously for 30 minutes at 0 °C. Next, 50% aqueous chloroacetaldehyde solution (26.3 mL, 0.203 mol) was slowly added. The reaction mixture was stirred overnight at room temperature. Upon completion of the reaction, the solution was acidified to pH < 7 with 1N hydrochloric acid and then extracted with ethyl acetate. The organic layers were combined, washed sequentially with water and saturated saline, and dried over anhydrous magnesium sulfate. Finally, the solvent was removed by concentration under reduced pressure to give the crude 6,7-dihydro-4(5H)-benzofuranone product (16.5 g), which was pure enough to be used directly in the next step of the reaction.

References

[1] Arkivoc, 2011, vol. 2011, # 9, p. 1 - 14
[2] Heterocycles, 2004, vol. 62, p. 807 - 813
[3] Bioorganic and Medicinal Chemistry, 2008, vol. 16, # 4, p. 1966 - 1982
[4] Journal of Organic Chemistry, 1988, vol. 53, # 17, p. 4135 - 4137
[5] Chemical and Pharmaceutical Bulletin, 1994, vol. 42, # 10, p. 2167 - 2169

6,7-Dihydro-4(5H)-benzofuranone Preparation Products And Raw materials

Raw materials

Preparation Products

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6,7-Dihydro-4(5H)-benzofuranone Suppliers

Belgium 1 China 140 Europe 1 Germany 1 India 4 Japan 2 Slovakia 1 Switzerland 1 United Kingdom 7 United States 10 Global 168

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View Lastest Price from 6,7-Dihydro-4(5H)-benzofuranone manufacturers

Henan Aochuang Chemical Co.,Ltd.

Product: 6,7-Dihydro-4(5H)-benzofuranone 16806-93-2
Price: US $0.00-0.00/kg
Min. Order: 1kg
Purity: 98%
Supply Ability: 1Ton
Release date: 2022-09-27

Hebei Chuanghai Biotechnology Co,.LTD

Product: 6,7-Dihydro-4(5H)-benzofuranone 16806-93-2
Price: US $9.00/KG
Min. Order: 1KG
Purity: 99.8%
Supply Ability: 100tons
Release date: 2024-08-23

Zibo Hangyu Biotechnology Development Co., Ltd

Product: 6,7-Dihydro-4(5H)-benzofuranone 16806-93-2
Price: US $80.00-800.00/kg
Min. Order: 10kg
Purity: 0.99
Supply Ability: 20tons
Release date: 2023-11-13

16806-93-2, 6,7-Dihydro-4(5H)-benzofuranoneRelated Search:

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