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1-METHYL-4-IMIDAZOLEACETIC ACID HYDROCHLORIDE

Product Name
1-METHYL-4-IMIDAZOLEACETIC ACID HYDROCHLORIDE
CAS No.
35454-39-8
Chemical Name
1-METHYL-4-IMIDAZOLEACETIC ACID HYDROCHLORIDE
Synonyms
hydrochloride - [M86572];1-METHYL-4-IMIDAZOLE ACETIC ACID HCL;1-Methyl-15N2-imidazol-4-yl acetic acid HCl;2-(1-METHYL-1H-IMIDAZOL-4-YL)ACETIC ACID HCL;1-METHYL-4-IMIDAZOLEACETIC ACID HYDROCHLORIDE;MECHAN. MEASURING STATION, AMELUNG*NO. D10013;1-MethyliMidazole-4-acetic acid hydrochloride;1-METHYL-4-IMIDAZOLEACETIC ACID HYDROGEN CHLORIDE;1-methyl-1H-imidazol-4-acetic acid monohydrochloride;(1-Methyl-1H-imidazol-4-yl)-acetic acid hydrochloride
CBNumber
CB7759318
Molecular Formula
C6H9ClN2O2
Formula Weight
176.6
MOL File
35454-39-8.mol
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1-METHYL-4-IMIDAZOLEACETIC ACID HYDROCHLORIDE Property

Melting point:
204-206℃
storage temp. 
under inert gas (nitrogen or Argon) at 2-8°C
solubility 
DMSO (Slightly), Methanol (Slightly), Water (Slightly)
form 
Solid
color 
Light Beige to Beige
Stability:
Hygroscopic
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Safety

WGK Germany 
3
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H302Harmful if swallowed

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P280Wear protective gloves/protective clothing/eye protection/face protection.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

Cayman Chemical
Product number
18815
Product name
1-Methyl-4-imidazoleacetic Acid (hydrochloride)
Purity
≥95%
Packaging
10mg
Price
$41
Updated
2024/03/01
Cayman Chemical
Product number
18815
Product name
1-Methyl-4-imidazoleacetic Acid (hydrochloride)
Purity
≥95%
Packaging
50mg
Price
$183
Updated
2024/03/01
Cayman Chemical
Product number
18815
Product name
1-Methyl-4-imidazoleacetic Acid (hydrochloride)
Purity
≥95%
Packaging
100mg
Price
$322
Updated
2024/03/01
Cayman Chemical
Product number
18815
Product name
1-Methyl-4-imidazoleacetic Acid (hydrochloride)
Purity
≥95%
Packaging
250mg
Price
$702
Updated
2024/03/01
TRC
Product number
M323800
Product name
1-Methyl-4-imidazoleaceticAcidHydrochloride
Packaging
250mg
Price
$640
Updated
2021/12/16
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1-METHYL-4-IMIDAZOLEACETIC ACID HYDROCHLORIDE Chemical Properties,Usage,Production

Description

1-Methyl-4-imidazoleacetic acid (MIMA) is a stable metabolite of histamine that is produced by the oxidation of the primary metabolite, N-methylhistamine. Urinary levels of MIMA are commonly measured to evaluate histamine secretion, particularly in the context of systemic mastocytosis.

Uses

1-Methyl-4-imidazoleacetic Acid Hydrochloride is a metabolite of histamine (H436500), which is produced by mast cells and involved with the inflammatory response. 1-Methyl-4-imidazoleacetic Acid Hydrochloride can also be used to synthesize N-[1-(9,10-methano-9-anthracenylmethyl)-4-piperidinyl]alkanamides and analogs as dopamine D2 receptor antagonists.

References

[1] KERR J W. IDENTIFICATION OF HISTAMINE METABOLITE 1-METHYL, 4-IMIDAZOLE ACETIC ACID IN HUMAN URINE AND ITS ABSENCE IN STATUS ASTHMATICUS.[J]. BMJ?: British Medical Journal, 1964, 2 5409: 606-608. DOI: 10.1136/bmj.2.5409.606
[2] J. J. VAN DOORMAAL. Tryptase and histamine metabolites as diagnostic indicators of indolent systemic mastocytosis without skin lesions[J]. Allergy, 2012, 67 5: 683-690. DOI: 10.1111/j.1398-9995.2012.02809.x
[3] BYRTHE J.P.R. VOS BSC  Pieter C van V V M  Eveline van der Veer PhD, PHD  André B M M, PHD , et al. Diminished reliability of tryptase as risk indicator of mastocytosis in older overweight subjects[J]. Journal of Allergy and Clinical Immunology, 2015, 135 3: Pages 792-798. DOI: 10.1016/j.jaci.2014.05.047
[4] A. TSOLAKIS. Histidine decarboxylase and urinary methylimidazoleacetic acid in gastric neuroendocrine cells and tumours.[C]//21 47 1. 2015: 13240-13249. DOI: 10.3748/wjg.v21.i47.13240

1-METHYL-4-IMIDAZOLEACETIC ACID HYDROCHLORIDE Preparation Products And Raw materials

Raw materials

Preparation Products

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1-METHYL-4-IMIDAZOLEACETIC ACID HYDROCHLORIDE Suppliers

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35454-39-8, 1-METHYL-4-IMIDAZOLEACETIC ACID HYDROCHLORIDERelated Search:

METHYL 2-(6-CHLOROIMIDAZO[1,2-A]PYRIDIN-2-YL)ACETATE (1H-IMIDAZOL-4-YL)-ACETALDEHYDE Imidazole-4-acetic acid (1-METHYL-1H-IMIDAZOL-4-YL)-ACETIC ACID 2-(3H-imidazol-4-yl)acetic acid 4-IMIDAZOLEACETIC ACID HYDROCHLORIDE (1-METHYL-1H-IMIDAZOL-4-YL)-ACETALDEHYDE 1-METHYL-4-IMIDAZOLEACETIC ACID HYDROCHLORIDE Imidazolyl-4-ethanol 2-(1,7-diazabicyclo[4.3.0]nona-2,4,6,8-tetraen-8-yl)acetic acid BASIONIC(TM) AC 75 (6-CHLORO-IMIDAZO[1,2-A]PYRIDIN-2-YL)-ACETIC ACID

  • 1-METHYL-4-IMIDAZOLE ACETIC ACID HCL
  • 1-METHYL-4-IMIDAZOLEACETIC ACID HYDROCHLORIDE
  • 1-methyl-1H-imidazol-4-acetic acid monohydrochloride
  • MECHAN. MEASURING STATION, AMELUNG*NO. D10013
  • 1-METHYL-4-IMIDAZOLEACETIC ACID HYDROGEN CHLORIDE
  • 1-MethyliMidazole-4-acetic acid hydrochloride
  • 2-(1-Methyl-1H-imidazol-4-yl)ethanoic acid hydrochloride
  • 2-(1-Methyl-1H-imidazol-4-yl)acetic acid hydrochloride
  • 2-(1-METHYL-1H-IMIDAZOL-4-YL)ACETIC ACID HCL
  • (1-Methyl-1H-imidazol-4-yl)-acetic acid hydrochloride
  • 1H-Imidazole-4-aceticacid, 1-methyl-, hydrochloride (1:1)
  • 1-Methyl-15N2-imidazol-4-yl acetic acid HCl
  • hydrochloride - [M86572]
  • 35454-39-8
  • Heterocyclic Building Blocks
  • Imidazoles
  • Building Blocks
  • Heterocyclic Compounds