2-(1,7-diazabicyclo[4.3.0]nona-2,4,6,8-tetraen-8-yl)acetic acid
Uses- Product Name
- 2-(1,7-diazabicyclo[4.3.0]nona-2,4,6,8-tetraen-8-yl)acetic acid
- CAS No.
- 19741-30-1
- Chemical Name
- 2-(1,7-diazabicyclo[4.3.0]nona-2,4,6,8-tetraen-8-yl)acetic acid
- Synonyms
- Nsc296220;Minodronic Impurity 2;Minodronic Acid Impurity 29;Imidazo[1,2-a]pyridin-2-acetic acid;Imidazo[1,2-a]pyridine-2-acetic acid;imidazol[1,2-A]pyridin-2-yl-acetic acid;IMIDAZO[1,2-A]PYRIDIN-2-YLACETIC ACID HYDROCHLORIDE;2-(Imidazo[1,2-a]pyridin-2-yl)acetic acid hydrochloride;2-(1,7-diazabicyclo[4.3.0]nona-2,4,6,8-tetraen-8-yl)acetic acid;2-(1,7-diazabicyclo[4.3.0]nona-2,4,6,8-tetraen-8-yl)acetic acid ISO 9001：2015 REACH
- CBNumber
- CB81459393
- Molecular Formula
- C9H8N2O2
- Formula Weight
- 176.17
- MOL File
- 19741-30-1.mol
2-(1,7-diazabicyclo[4.3.0]nona-2,4,6,8-tetraen-8-yl)acetic acid Property
- Melting point:
- 207-208 °C(Solv: ethanol (64-17-5); water (7732-18-5))
- Density
- 1.35±0.1 g/cm3(Predicted)
- storage temp.
- 2-8°C
- form
- solid
- pka
- 1.91±0.10(Predicted)
Safety
- HS Code
- 2933998090
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Danger
- Hazard statements
-
H318Causes serious eye damage
- Precautionary statements
-
P280Wear protective gloves/protective clothing/eye protection/face protection.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
N-Bromosuccinimide Price
- Product number
- I707038
- Product name
- 2-{imidazo[1,2-a]pyridin-2-yl}aceticacid
- Packaging
- 10mg
- Price
- $45
- Updated
- 2021/12/16
- Product number
- 7268AH
- Product name
- Imidazo[1,2-a]pyridin-2-yl-aceticacid
- Packaging
- 250mg
- Price
- $235
- Updated
- 2021/12/16
- Product number
- OR953789
- Product name
- Imidazo[1,2-a]pyridin-2-yl-aceticacid
- Purity
- 95%
- Packaging
- 250mg
- Price
- $240
- Updated
- 2021/12/16
- Product number
- CHM0118971
- Product name
- IMIDAZO[1,2-A]PYRIDIN-2-YLACETIC ACID HYDROCHLORIDE
- Purity
- 95.00%
- Packaging
- 1G
- Price
- $983.52
- Updated
- 2021/12/16
- Product number
- CHM0118971
- Product name
- IMIDAZO[1,2-A]PYRIDIN-2-YLACETIC ACID HYDROCHLORIDE
- Purity
- 95.00%
- Packaging
- 2.5G
- Price
- $1473.14
- Updated
- 2021/12/16
2-(1,7-diazabicyclo[4.3.0]nona-2,4,6,8-tetraen-8-yl)acetic acid Chemical Properties,Usage,Production
Uses
2-{imidazo[1,2-a]pyridin-2-yl}acetic acid is a useful research chemical.
Synthesis
504-29-0
27807-84-7
19741-30-1
The general procedure for the synthesis of 2-(imidazo[1,2-a]pyridin-2-yl)acetic acid from 2-aminopyridine (20 g, 212 mmol) and ethyl 4-chloro-3-oxobutanoate (28.7 mL, 212 mmol) is as follows: firstly, 2-aminopyridine was added to 300 mL of ethanol, followed by the addition to a reaction vessel containing a magnetic stir bar of 4-chloro-3- ethyl oxobutyrate. The reaction mixture was stirred at 80°C for 20 hours. Upon completion of the reaction, the ethanol was evaporated and the crude product was dissolved in 100 mL of 0.5 N hydrochloric acid. The aqueous phase was extracted three times with 50 mL of dichloromethane to remove organic impurities. The product was retained in the aqueous phase and 37 g of crude product was obtained by concentration under reduced pressure. The crude product was purified by silica gel chromatography using a dichloromethane/methanol gradient elution (yield: 8.3 g, 19% yield). The resulting ester was dissolved in 200 mL of methanol and 7 mL of 10 M sodium hydroxide solution was added. The reaction mixture was stirred at room temperature for 12 h until the ester was completely saponified. After evaporation of methanol, the aqueous phase was acidified to pH=7. The precipitated product was filtered and washed with ether (yield: 7.6 g, 99%).LCMS (Method 1): retention time (Rt) = 0.435 min; HRMS (ESIpos): m/z [M + H]+ C9H8N2O2 Calculated value 177.0659, measured value 177.0660.
References
[1] Patent: EP3275885, 2018, A1. Location in patent: Paragraph 0118; 0119
2-(1,7-diazabicyclo[4.3.0]nona-2,4,6,8-tetraen-8-yl)acetic acid Preparation Products And Raw materials
Raw materials
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View Lastest Price from 2-(1,7-diazabicyclo[4.3.0]nona-2,4,6,8-tetraen-8-yl)acetic acid manufacturers
- Product
- 2-(1,7-diazabicyclo[4.3.0]nona-2,4,6,8-tetraen-8-yl)acetic acid 19741-30-1
- Price
- US $3.00/KG
- Min. Order
- 1KG
- Purity
- 98%
- Supply Ability
- 200KG
- Release date
- 2020-03-23