5-PROPOXY-3-(1,2,3,6-TETRAHYDRO-4-PYRIDINYL)-1H-PYRROLO[3,2-B]PYRIDINE HYDROCHLORIDE
- Product Name
- 5-PROPOXY-3-(1,2,3,6-TETRAHYDRO-4-PYRIDINYL)-1H-PYRROLO[3,2-B]PYRIDINE HYDROCHLORIDE
- CAS No.
- 131084-35-0
- Chemical Name
- 5-PROPOXY-3-(1,2,3,6-TETRAHYDRO-4-PYRIDINYL)-1H-PYRROLO[3,2-B]PYRIDINE HYDROCHLORIDE
- Synonyms
- CS-1071;CP 94253;CP94253HCl;CP 94253 Free base;CP 94253 HYDROCHLORIDE;CP-94,253 dihydrochloride;3-(1,2,5,6-tetrahydro-4-pyridyl)-5-propoxypyrrolo[3,2-b]pyridine;5-Propoxy-3-(1,2,3,6-tetrahydro-4-pyridinyl)-1H-pyrrolo[3,2-b]pyridine;5-Propoxy-3-(1,2,3,6-tetrahydropyridin-4-yl)-1H-pyrrolo[3,2-b]pyridine;4-{5-propoxy-1H-pyrrolo[3,2-b]pyridin-3-yl}-1,2,3,6-tetrahydropyridine
- CBNumber
- CB7761214
- Molecular Formula
- C15H19N3O
- Formula Weight
- 257.33
- MOL File
- 131084-35-0.mol
5-PROPOXY-3-(1,2,3,6-TETRAHYDRO-4-PYRIDINYL)-1H-PYRROLO[3,2-B]PYRIDINE HYDROCHLORIDE Property
- Melting point:
- >230°C (dec.)
- Boiling point:
- 442.9±45.0 °C(Predicted)
- Density
- 1.166
- storage temp.
- Desiccate at RT
- solubility
- H2O: soluble15mg/mL, clear
- form
- powder
- pka
- 14.37±0.40(Predicted)
- color
- white to beige
Safety
- Hazard Codes
- Xn
- Risk Statements
- 22-36/37/38
- Safety Statements
- 26
- WGK Germany
- 3
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H302Harmful if swallowed
H315Causes skin irritation
H319Causes serious eye irritation
H335May cause respiratory irritation
- Precautionary statements
-
P261Avoid breathing dust/fume/gas/mist/vapours/spray.
P264Wash hands thoroughly after handling.
P264Wash skin thouroughly after handling.
P270Do not eat, drink or smoke when using this product.
P301+P312IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.
P302+P352IF ON SKIN: wash with plenty of soap and water.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
N-Bromosuccinimide Price
- Product number
- SML0588
- Product name
- CP-94,253 dihydrochloride
- Purity
- ≥98% (HPLC)
- Packaging
- 5mg
- Price
- $119
- Updated
- 2024/03/01
- Product number
- SML0588
- Product name
- CP-94,253 dihydrochloride
- Purity
- ≥98% (HPLC)
- Packaging
- 25mg
- Price
- $481
- Updated
- 2024/03/01
- Product number
- 1317
- Product name
- CP94253hydrochloride
- Purity
- ≥98%(HPLC)
- Packaging
- 10
- Price
- $210
- Updated
- 2021/12/16
- Product number
- 1317
- Product name
- CP94253hydrochloride
- Purity
- ≥98%(HPLC)
- Packaging
- 50
- Price
- $822
- Updated
- 2021/12/16
- Product number
- 255041
- Product name
- CP 94253 hydrochloride
- Packaging
- 10mg
- Price
- $466
- Updated
- 2021/12/16
5-PROPOXY-3-(1,2,3,6-TETRAHYDRO-4-PYRIDINYL)-1H-PYRROLO[3,2-B]PYRIDINE HYDROCHLORIDE Chemical Properties,Usage,Production
Uses
CP 94253 Hydrochloride is a potent and selective serotonin 5-HT1B receptor agonist with anticonvulsant activity.
Definition
ChEBI: 5-propoxy-3-(1,2,3,6-tetrahydropyridin-4-yl)-1H-pyrrolo[3,2-b]pyridine is a pyrrolopyridine.
Biological Activity
Potent, selective 5-HT 1B agonist (K i values are 89, 2, 860, 49 and 1,600 nM for 5-HT 1A , 5-HT 1B , 5-HT 1C , 5-HT 1D and 5-HT 2 receptors respectively). Centrally active upon systemic administration in vivo .
Biochem/physiol Actions
CP-94,253 is a potent and selective serotonin 5-HT1B receptor agonist with approximately 25x and 40x selectivity over the closely related 5-HT1D and 5-HT1A receptors. Ki values are 89, 2, 860, 49 and 1,600 nM for 5-HT1A, 5-HT1B, 5-HT1C, 5-HT1D and 5-HT2 receptors respectively. CP-94,253 was found to be anxiolytic in animal models; dose-dependently enhanced reinforcing effects of cocaine (self-administration);and reduced food intake.
5-PROPOXY-3-(1,2,3,6-TETRAHYDRO-4-PYRIDINYL)-1H-PYRROLO[3,2-B]PYRIDINE HYDROCHLORIDE Preparation Products And Raw materials
Raw materials
Preparation Products
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