L-NIO DIHYDROCHLORIDE

Product Name: L-NIO DIHYDROCHLORIDE
CAS No.: 36889-13-1
Chemical Name: L-NIO DIHYDROCHLORIDE
Synonyms: L-NIO;L-NIO, 2HCL;L-NIO dihydrochlorid;L-NIO DIHYDROCHLORIDE;L-NIO (hydrochloride);n(g)-iminoethylornithine;L-N5-(1-Iminoethyl)ornithine;L-Ornithine, N5-(1-iminoethyl)-;L-NIO DIHYDROCHLORIDE USP/EP/BP;L-N5-(1-Iminoethyl)Ornithine,HCl
CBNumber: CB7776636
Molecular Formula: C7H15N3O2
Formula Weight: 173.21
MOL File: 36889-13-1.mol

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L-NIO DIHYDROCHLORIDE Property

Melting point:: 225-226°C
storage temp.: -20°C
solubility: Methanol (Slightly), Water (Slightly)
form: Solid
color: White to Off-White
Water Solubility: H2O: 2mg/mL, clear (warmed)
Stability:: Hygroscopic

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Safety

Safety Statements: 24/25
HS Code: 29224985

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Hazard and Precautionary Statements (GHS)

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N-Bromosuccinimide Price

Cayman Chemical

Product number: 80320
Product name: L-NIO (hydrochloride)
Purity: ≥95%
Packaging: 5mg
Price: $17
Updated: 2024/03/01

Cayman Chemical

Product number: 80320
Product name: L-NIO (hydrochloride)
Purity: ≥95%
Packaging: 10mg
Price: $30
Updated: 2024/03/01

Cayman Chemical

Product number: 80320
Product name: L-NIO (hydrochloride)
Purity: ≥95%
Packaging: 50mg
Price: $118
Updated: 2024/03/01

Cayman Chemical

Product number: 80320
Product name: L-NIO (hydrochloride)
Purity: ≥95%
Packaging: 100mg
Price: $207
Updated: 2024/03/01

Tocris

Product number: 0546
Product name: L-NIOdihydrochloride
Packaging: 10
Price: $86
Updated: 2021/12/16

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L-NIO DIHYDROCHLORIDE Chemical Properties,Usage,Production

Description

L-NIO is a non-selective inhibitor of all NOS isoforms. The K_i values for nNOS (rat), eNOS (bovine), and iNOS (mouse) are 1.7, 3.9, and 3.9 μM, respectively. L-NIO inhibits endothelial-dependent relaxation induced by acetylcholine in rat aortic rings and hypotensive responses to acetylcholine and bradykinin.

Chemical Properties

White Crystalline Solid

Uses

A potent and reversible inhibitor of NO synthase of adrenal glands, brain, and vascular endothelial cells

Definition

ChEBI: L-NIO is a L-alpha-amino acid.

Biological Activity

Potent inhibitor of endothelial NO synthase (IC 50 = 500 nM). Also inhibits iNOS and nNOS. Active in vivo .

References

[1] B R BABU O W G. N5-(1-Imino-3-butenyl)-L-ornithine. A neuronal isoform selective mechanism-based inactivator of nitric oxide synthase.[J]. The Journal of Biological Chemistry, 1998, 273 15: 8882-8889. DOI: 10.1074/jbc.273.15.8882

L-NIO DIHYDROCHLORIDE Preparation Products And Raw materials

Raw materials

Preparation Products

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L-NIO DIHYDROCHLORIDE Suppliers

Belgium 1 Canada 1 China 29 Germany 3 Japan 2 Switzerland 2 United Kingdom 5 United States 14 Global 57

J & K SCIENTIFIC LTD.

Tel: 18210857532; 18210857532
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3B Pharmachem (Wuhan) International Co.,Ltd.

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Thermo Fisher Scientific

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Country: China
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EMMX Biotechnology LLC

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Shanghai EFE Biological Technology Co., Ltd.

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Shandong Ono Chemical Co., Ltd.

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Dideu Industries Group Limited

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Hubei Jusheng Technology Co.,Ltd.

Tel: 18871490254
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ChemeGen(Shanghai) Biotechnology Co.,Ltd.

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36889-13-1, L-NIO DIHYDROCHLORIDERelated Search:

L-Glutamine L-Ornithine L-ORNITHINE DIHYDROCHLORIDE L(+)-Ornithine hydrochloride ETHYL-L-NIO (HYDROCHLORIDE) L-NIO DIHYDROCHLORIDE L-N5-(1-IMINOPROPYL) ORNITHINE (HYDROCHLORIDE) VINYL-L-NIO HYDROCHLORIDE

L-NIO

L-NIO, 2HCL

n(g)-iminoethylornithine

NG-(1-IMINOETHYL)-L-ORNITHINE HYDROCHLORIDE

N5-(1-IMINOETHYL)-L-ORNITHINE DIHYDROCHLORIDE

N(5)-(1-IMINOETHYL)-L-ORNITHINE HCL

N5-(1-IMINOETHYL)-L-ORNITHINE HYDROCHLORIDE

L-N5-(I-IMINOETHYL)ORNITHINE HYDROCHLORI DE POTENT IRREVERSIBLE N

L-N5-(1-Iminoethyl)Ornithine,HCl

L-NIO DIHYDROCHLORIDE

L-N5-(1-IMINOETHYL)-ORNITHINE 2HCL

L-N5-(1-IMINOETHYL)ORNITHINE, DIHYDROCHLORIDE

L-N5-(1-IMINOETHYL) ORNITHINE, HYDROCHLORIDE

L-N5-(I-IMINOETHYL)ORNITHINE HYDROCHLORIDE

L-NIO (hydrochloride)

L-N5-(1-Iminoethyl)ornithine

L-N5-(1-Iminoethyl)-ornithine dihydrochloride,97%

L-Ornithine, N5-(1-iminoethyl)-

L-NIOdihydrochloride,N5-(1-Iminoethyl)-L-ornithinedihydrochloride

L-NIO DIHYDROCHLORIDE USP/EP/BP

L-NIO dihydrochlorid

36889-13-1

C7H15N3O2HCl

C7H16ClN3O2

C7H15N3O22HCl

Amino Acids 13C, 2H, 15N

Amino Acids & Derivatives

Nitric Oxide Reagents

Nitric Oxide