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L-NIO DIHYDROCHLORIDE

Product Name
L-NIO DIHYDROCHLORIDE
CAS No.
36889-13-1
Chemical Name
L-NIO DIHYDROCHLORIDE
Synonyms
L-NIO;L-NIO, 2HCL;L-NIO dihydrochlorid;L-NIO DIHYDROCHLORIDE;L-NIO (hydrochloride);n(g)-iminoethylornithine;L-N5-(1-Iminoethyl)ornithine;L-Ornithine, N5-(1-iminoethyl)-;L-NIO DIHYDROCHLORIDE USP/EP/BP;L-N5-(1-Iminoethyl)Ornithine,HCl
CBNumber
CB7776636
Molecular Formula
C7H15N3O2
Formula Weight
173.21
MOL File
36889-13-1.mol
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L-NIO DIHYDROCHLORIDE Property

Melting point:
225-226°C
storage temp. 
-20°C
solubility 
Methanol (Slightly), Water (Slightly)
form 
Solid
color 
White to Off-White
Water Solubility 
H2O: 2mg/mL, clear (warmed)
Stability:
Hygroscopic
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Safety

Safety Statements 
24/25
HS Code 
29224985
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Hazard and Precautionary Statements (GHS)

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N-Bromosuccinimide Price

Cayman Chemical
Product number
80320
Product name
L-NIO (hydrochloride)
Purity
≥95%
Packaging
5mg
Price
$17
Updated
2024/03/01
Cayman Chemical
Product number
80320
Product name
L-NIO (hydrochloride)
Purity
≥95%
Packaging
10mg
Price
$30
Updated
2024/03/01
Cayman Chemical
Product number
80320
Product name
L-NIO (hydrochloride)
Purity
≥95%
Packaging
50mg
Price
$118
Updated
2024/03/01
Cayman Chemical
Product number
80320
Product name
L-NIO (hydrochloride)
Purity
≥95%
Packaging
100mg
Price
$207
Updated
2024/03/01
Tocris
Product number
0546
Product name
L-NIOdihydrochloride
Packaging
10
Price
$86
Updated
2021/12/16
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L-NIO DIHYDROCHLORIDE Chemical Properties,Usage,Production

Description

L-NIO is a non-selective inhibitor of all NOS isoforms. The Ki values for nNOS (rat), eNOS (bovine), and iNOS (mouse) are 1.7, 3.9, and 3.9 μM, respectively. L-NIO inhibits endothelial-dependent relaxation induced by acetylcholine in rat aortic rings and hypotensive responses to acetylcholine and bradykinin.

Chemical Properties

White Crystalline Solid

Uses

A potent and reversible inhibitor of NO synthase of adrenal glands, brain, and vascular endothelial cells

Definition

ChEBI: L-NIO is a L-alpha-amino acid.

Biological Activity

Potent inhibitor of endothelial NO synthase (IC 50 = 500 nM). Also inhibits iNOS and nNOS. Active in vivo .

References

[1] B R BABU  O W G. N5-(1-Imino-3-butenyl)-L-ornithine. A neuronal isoform selective mechanism-based inactivator of nitric oxide synthase.[J]. The Journal of Biological Chemistry, 1998, 273 15: 8882-8889. DOI: 10.1074/jbc.273.15.8882

L-NIO DIHYDROCHLORIDE Preparation Products And Raw materials

Raw materials

Preparation Products

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L-NIO DIHYDROCHLORIDE Suppliers

Belgium 1 Canada 1 China 29 Germany 3 Japan 2 Switzerland 2 United Kingdom 5 United States 14 Global 57
Acros Organics
Tel
--
Fax
--
Email
info@acros.com
Country
Belgium
ProdList
6772
Advantage
81

36889-13-1, L-NIO DIHYDROCHLORIDERelated Search:

L-Glutamine L-Ornithine L-ORNITHINE DIHYDROCHLORIDE L(+)-Ornithine hydrochloride ETHYL-L-NIO (HYDROCHLORIDE) L-NIO DIHYDROCHLORIDE L-N5-(1-IMINOPROPYL) ORNITHINE (HYDROCHLORIDE) VINYL-L-NIO HYDROCHLORIDE

  • L-NIO
  • L-NIO, 2HCL
  • n(g)-iminoethylornithine
  • NG-(1-IMINOETHYL)-L-ORNITHINE HYDROCHLORIDE
  • N5-(1-IMINOETHYL)-L-ORNITHINE DIHYDROCHLORIDE
  • N(5)-(1-IMINOETHYL)-L-ORNITHINE HCL
  • N5-(1-IMINOETHYL)-L-ORNITHINE HYDROCHLORIDE
  • L-N5-(I-IMINOETHYL)ORNITHINE HYDROCHLORI DE POTENT IRREVERSIBLE N
  • L-N5-(1-Iminoethyl)Ornithine,HCl
  • L-NIO DIHYDROCHLORIDE
  • L-N5-(1-IMINOETHYL)-ORNITHINE 2HCL
  • L-N5-(1-IMINOETHYL)ORNITHINE, DIHYDROCHLORIDE
  • L-N5-(1-IMINOETHYL) ORNITHINE, HYDROCHLORIDE
  • L-N5-(I-IMINOETHYL)ORNITHINE HYDROCHLORIDE
  • L-NIO (hydrochloride)
  • L-N5-(1-Iminoethyl)ornithine
  • L-N5-(1-Iminoethyl)-ornithine dihydrochloride,97%
  • L-Ornithine, N5-(1-iminoethyl)-
  • L-NIOdihydrochloride,N5-(1-Iminoethyl)-L-ornithinedihydrochloride
  • L-NIO DIHYDROCHLORIDE USP/EP/BP
  • L-NIO dihydrochlorid
  • 36889-13-1
  • C7H15N3O2HCl
  • C7H16ClN3O2
  • C7H15N3O22HCl
  • Amino Acids 13C, 2H, 15N
  • Amino Acids & Derivatives
  • Nitric Oxide Reagents
  • Nitric Oxide