N-(3-Aminophenyl)methanesulfamide
- Product Name
- N-(3-Aminophenyl)methanesulfamide
- CAS No.
- 37045-73-1
- Chemical Name
- N-(3-Aminophenyl)methanesulfamide
- Synonyms
- N-(3-Aminophenyl);m-Aminomethylsulfonylaniline;3-(Methylsulfonamido)aniline;n-(3-aminophenyl)methanesulfon;3-(Methylsulfonylamino)aniline;3-N-(Methylsulfonyl)aminoaniline;N-(3-Aminophenyl)methanesulfamide;N-methylsulfonyl-m-phenylenediamine;_x000D_3-(Methylsulfonamido)aniline;N-[(3-aMinophenyl)Methyl]sulfonaMide
- CBNumber
- CB7779905
- Molecular Formula
- C7H10N2O2S
- Formula Weight
- 186.23
- MOL File
- 37045-73-1.mol
N-(3-Aminophenyl)methanesulfamide Property
- Melting point:
- 117-121 °C (lit.)
- Boiling point:
- 361.8±44.0 °C(Predicted)
- Density
- 1.408±0.06 g/cm3(Predicted)
- storage temp.
- Keep in dark place,Inert atmosphere,Room temperature
- pka
- 9.12±0.10(Predicted)
- InChI
- InChI=1S/C7H10N2O2S/c1-12(10,11)9-7-4-2-3-6(8)5-7/h2-5,9H,8H2,1H3
- InChIKey
- UQRRCQRFQGOHAI-UHFFFAOYSA-N
- SMILES
- CS(NC1=CC=CC(N)=C1)(=O)=O
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H315Causes skin irritation
H319Causes serious eye irritation
H335May cause respiratory irritation
- Precautionary statements
-
P261Avoid breathing dust/fume/gas/mist/vapours/spray.
P264Wash hands thoroughly after handling.
P264Wash skin thouroughly after handling.
P271Use only outdoors or in a well-ventilated area.
P280Wear protective gloves/protective clothing/eye protection/face protection.
P302+P352IF ON SKIN: wash with plenty of soap and water.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
N-Bromosuccinimide Price
- Product number
- 548278
- Product name
- N-(3-Aminophenyl)methanesulfonamide
- Packaging
- 5g
- Price
- $56
- Updated
- 2023/06/20
- Product number
- A637983
- Product name
- N-(3-Aminophenyl)methanesulfonamide
- Packaging
- 2.5g
- Price
- $75
- Updated
- 2021/12/16
- Product number
- 093149
- Product name
- N-(3-Aminophenyl)methanesulfamide
- Purity
- 95+%
- Packaging
- 1g
- Price
- $15
- Updated
- 2021/12/16
- Product number
- FA76297
- Product name
- N-(3-Aminophenyl)methanesulfamide
- Packaging
- 1g
- Price
- $55
- Updated
- 2021/12/16
- Product number
- FA76297
- Product name
- N-(3-Aminophenyl)methanesulfamide
- Packaging
- 2g
- Price
- $90
- Updated
- 2021/12/16
N-(3-Aminophenyl)methanesulfamide Chemical Properties,Usage,Production
Chemical Properties
Light red solid
Uses
Reactant for:
- Preparation of biologically and pharmacologically active molecules
Synthesis
63228-62-6
37045-73-1
The general procedure for the synthesis of m-aminomethanesulfonanilide from N-(methylsulfonyl)-3-nitroanilide was as follows: N-(3-nitrophenyl)methanesulfonamide (2.6 g, 12.0 mmol, 1.00 equiv), iron powder (3.38 g, 60.5 mmol, 5.03 equiv) and ammonium chloride (6.48 g, 121 mmol, 10.1 equiv) were dissolved in a solvent mixture of methanol (40 mL) and water (20 mL). The reaction mixture was heated at 70 °C for the reaction. After completion of the reaction, the insoluble material was removed by filtration through diatomaceous earth. The filtrate was concentrated under reduced pressure, diluted with ethyl acetate, washed twice sequentially with saturated saline and the organic phase was dried with anhydrous sodium sulfate. Finally, it was purified by column chromatography (silica gel 115 g, eluent: 20% to 40% ethyl acetate/hexane) to give 1.55 g of orange solid product in 69% yield.
References
[1] Patent: WO2014/6066, 2014, A1. Location in patent: Paragraph 0235
[2] Patent: WO2012/59932, 2012, A1. Location in patent: Page/Page column 149-150
[3] ChemMedChem, 2014, vol. 9, # 5, p. 962 - 972
[4] Patent: US2663732, 1950,
N-(3-Aminophenyl)methanesulfamide Preparation Products And Raw materials
Raw materials
Preparation Products
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