ChemicalBook > CAS DataBase List > N-(3-Aminophenyl)methanesulfamide

N-(3-Aminophenyl)methanesulfamide

Product Name: N-(3-Aminophenyl)methanesulfamide
CAS No.: 37045-73-1
Chemical Name: N-(3-Aminophenyl)methanesulfamide
Synonyms: N-(3-Aminophenyl);m-Aminomethylsulfonylaniline;3-(Methylsulfonamido)aniline;n-(3-aminophenyl)methanesulfon;3-(Methylsulfonylamino)aniline;3-N-(Methylsulfonyl)aminoaniline;N-(3-Aminophenyl)methanesulfamide;N-methylsulfonyl-m-phenylenediamine;_x000D_3-(Methylsulfonamido)aniline;N-[(3-aMinophenyl)Methyl]sulfonaMide
CBNumber: CB7779905
Molecular Formula: C7H10N2O2S
Formula Weight: 186.23
MOL File: 37045-73-1.mol

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N-(3-Aminophenyl)methanesulfamide Property

Melting point:: 117-121 °C (lit.)
Boiling point:: 361.8±44.0 °C(Predicted)
Density: 1.408±0.06 g/cm3(Predicted)
storage temp.: Keep in dark place,Inert atmosphere,Room temperature
pka: 9.12±0.10(Predicted)
InChI: InChI=1S/C7H10N2O2S/c1-12(10,11)9-7-4-2-3-6(8)5-7/h2-5,9H,8H2,1H3
InChIKey: UQRRCQRFQGOHAI-UHFFFAOYSA-N
SMILES: CS(NC1=CC=CC(N)=C1)(=O)=O

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Safety

Hazard Codes: Xi
Risk Statements: 36/37/38
Safety Statements: 26-36
WGK Germany: 3
HazardClass: IRRITANT
HS Code: 29350090

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P271Use only outdoors or in a well-ventilated area.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P302+P352IF ON SKIN: wash with plenty of soap and water.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

Sigma-Aldrich

Product number: 548278
Product name: N-(3-Aminophenyl)methanesulfonamide
Packaging: 5g
Price: $56
Updated: 2023/06/20

TRC

Product number: A637983
Product name: N-(3-Aminophenyl)methanesulfonamide
Packaging: 2.5g
Price: $75
Updated: 2021/12/16

Oakwood

Product number: 093149
Product name: N-(3-Aminophenyl)methanesulfamide
Purity: 95+%
Packaging: 1g
Price: $15
Updated: 2021/12/16

Biosynth Carbosynth

Product number: FA76297
Product name: N-(3-Aminophenyl)methanesulfamide
Packaging: 1g
Price: $55
Updated: 2021/12/16

Biosynth Carbosynth

Product number: FA76297
Product name: N-(3-Aminophenyl)methanesulfamide
Packaging: 2g
Price: $90
Updated: 2021/12/16

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N-(3-Aminophenyl)methanesulfamide Chemical Properties,Usage,Production

Chemical Properties

Light red solid

Uses

Reactant for:

Preparation of biologically and pharmacologically active molecules

Synthesis

63228-62-6

37045-73-1

The general procedure for the synthesis of m-aminomethanesulfonanilide from N-(methylsulfonyl)-3-nitroanilide was as follows: N-(3-nitrophenyl)methanesulfonamide (2.6 g, 12.0 mmol, 1.00 equiv), iron powder (3.38 g, 60.5 mmol, 5.03 equiv) and ammonium chloride (6.48 g, 121 mmol, 10.1 equiv) were dissolved in a solvent mixture of methanol (40 mL) and water (20 mL). The reaction mixture was heated at 70 °C for the reaction. After completion of the reaction, the insoluble material was removed by filtration through diatomaceous earth. The filtrate was concentrated under reduced pressure, diluted with ethyl acetate, washed twice sequentially with saturated saline and the organic phase was dried with anhydrous sodium sulfate. Finally, it was purified by column chromatography (silica gel 115 g, eluent: 20% to 40% ethyl acetate/hexane) to give 1.55 g of orange solid product in 69% yield.

References

[1] Patent: WO2014/6066, 2014, A1. Location in patent: Paragraph 0235
[2] Patent: WO2012/59932, 2012, A1. Location in patent: Page/Page column 149-150
[3] ChemMedChem, 2014, vol. 9, # 5, p. 962 - 972
[4] Patent: US2663732, 1950,

N-(3-Aminophenyl)methanesulfamide Preparation Products And Raw materials

Raw materials

Ethanol Methanesulfonyl chloride Diethyl ether Benzene RANEY NICKEL Hydrochloric acid Hydrogen Sodium hydroxide 3-Nitroaniline 1-Butanol Activated carbon

Preparation Products

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37045-73-1, N-(3-Aminophenyl)methanesulfamideRelated Search:

P-AMINOBENZAMIDE GLUTAMIC ACID Sulfanilamide N,N-Dimethyl-1,4-phenylenediamine 4'-Aminoacetanilide 3-(N,N-Dipropyl)amino-N-methylsulfonylaniline SULFENTRAZONE L-ACYLASE N-(5-AMINO-2-METHYLPHENYL)METHANESULFONAMIDE N-(2-FLUORO-5-NITROPHENYL)METHANESULFONAMIDE N-(3-Aminophenyl)methanesulfamide AURORA 11114 N-(4-(((4-CHLORO-3-NITROPHENYL)AMINO)SULFONYL)PHENYL)ETHANAMIDE AURORA 22134 AURORA 2939 N1-(3-[(2,5,6-TRICHLOROPYRIMIDIN-4-YL)AMINO]PHENYL)-4-(TRIFLUOROMETHYL)BENZENE-1-SULFONAMIDE 1,2-DITOSYLAMINO-4-FLUORO-5-NITROBENZENE SALOR-INT L305545-1EA N1-(2-METHYL-3-NITROPHENYL)-N1-([(2-METHYL-3-NITROPHENYL)IMINO]METHYL)-2-NITROBENZENE-1-SULFONAMIDE

N-(3-AMINO PHENYL)METHANE SULFONAMIDE

m-Aminomethylsulfonylaniline

n-(3-aminophenyl)methanesulfon

N-(3-Aminophenyl)methanesulfamide

3-(Methylsulfonamido)aniline

N-methylsulfonyl-m-phenylenediamine

N-(3-Aminophenyl)methanesulfonamide ,97%

N-(3-Aminophenyl)

N-(3-AMinophenyl)MethanesulfaMide/N-(3-AMinophenyl)Methanesulfon

N-(3-AMinophenyl)MethanesulfaMide/N-(3-AMinophenyl)MethanesulfonaMide

N-[(3-aMinophenyl)Methyl]sulfonaMide

3-(Methylsulfonylamino)aniline

3-N-(Methylsulfonyl)aminoaniline

N-(3-Aminophenyl)methanesulfonamide,N-(3-Aminophenyl)methanesulfamide

Methanesulfonamide, N-(3-aminophenyl)-

_x000D_3-(Methylsulfonamido)aniline

<i>N</i>-(3-Aminophenyl)methanesulfonamide

37045-73-1

Building Blocks

Organic Building Blocks

Sulfur Compounds

Sulfonamides/Sulfinamides