Methyl palmitate Property

Melting point:

32-35 °C (lit.)

Boiling point:

185 °C/10 mmHg (lit.)

Density 

0.852 g/mL at 25 °C (lit.)

vapor pressure 

0.008Pa at 25℃

refractive index 

n20/D 1.4512(lit.)

Flash point:

>230 °F

storage temp. 

2-8°C

solubility 

Chloroform (Sparingly), Methanol (Slightly)

form 

Liquid or Low Melting Solid

Specific Gravity

0.852

color 

Clear colorless

Odor

at 100.00 %. oily waxy fatty orris

Odor Type

waxy

Water Solubility 

INSOLUBLE

BRN 

1780973

LogP

7.38 at 36℃

CAS DataBase Reference

112-39-0(CAS DataBase Reference)

NIST Chemistry Reference

Hexadecanoic acid, methyl ester(112-39-0)

EPA Substance Registry System

Methyl palmitate (112-39-0)

Safety

Safety Statements 

22-24/25

WGK Germany 

1

TSCA 

Yes

HS Code 

29157090

Hazardous Substances Data

112-39-0(Hazardous Substances Data)

Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H315Causes skin irritation

Precautionary statements

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P302+P352IF ON SKIN: wash with plenty of soap and water.

P321Specific treatment (see … on this label).

P332+P313IF SKIN irritation occurs: Get medical advice/attention.

P362Take off contaminated clothing and wash before reuse.

Methyl palmitate Chemical Properties,Usage,Production

Chemical Properties

Clear colorless liquid or low melting solid. Soluble in alcohol, acetone, chloroform and benzene, soluble in ether, insoluble in water.

Uses

Methyl palmitate is used in the preparation of detergents, emulsifiers, wetting agents, stabilizers, resins, lubricants, plasticizers and animal feeds. It exhibits an anti-inflammatory and anti-fibrotic agent and prevents bleomycin-induced lung inflammation and fibrosis in rats. In addition, it also prevents carbon tetrachloride-induced liver fibrosis linked to reduce transforming growth factor beta, which is a secreted protein that controls proliferation, cellular differentiation and other functions in most cells.

Uses

Methyl palmitate can be used as an additive in food and cosmetic industries for the stabilization of fats and oil products by slowing down the auto-oxidation of unsaturated fatty acids.

Application

Methyl Palmitate is a fatty acid ester essential oil that naturally occurs in many plant species. Methyl Palmitate concentration in cells are known to be modulated by methanol. In experimental studies with isolated Kupffer cells, Methyl palmitate exhibited inhibitory activity towards phagocytosis and decreases cell viability.

Definition

ChEBI: Methyl palmitate is a fatty acid methyl ester. It has a role as a metabolite.

Biological Functions

Saturated fatty acids are synthesized by both plants and animals from acetyl coenzyme A as a form of long- term energy storage. Palmitic acid is a common 16-carbon saturated fat that represents 10-20% of the normal human dietary fat intake, and approximately 25% of the total plasma fatty acids in plasma lipoproteins. Saturated free fatty acids induce the expression of cyclooxygenase-2. Palmitic acid methyl ester (MP) is a fatty acid ester whose concentration in cells is modulated by methanol. In studies with isolated Kupffer cells, MP inhibits phagocytosis and decreases cell viability. In cells treated with lipopolysaccharide, it also decreases secretion of interleukin-10, TNF-α, nitric oxide, and prostaglandin E2. This effect is thought to occur by the inhibition of NF-κB.

Synthesis Reference(s)

Synthetic Communications, 16, p. 1423, 1986 DOI: 10.1080/00397918608056391

General Description

Methyl palmitate (PAME), a fatty acid ester of palmitic acid, is a muscurinic receptors antagonist. Methyl palmitate functions as a vasodilator and relaxes the arterioles in retina upon electrical depolarization. In the superior cervical ganglion, methyl palmitate modulates nicotinic receptor. Endogenous methyl palmitate modulates nicotinic receptor-mediated transmission in the superior cervical ganglion. PAME activates Kv7 channels and promotes perivascular adipose tissue.

Flammability and Explosibility

Non flammable

Biochem/physiol Actions

Methyl palmitate has anti-inflammatory and anti-fibrotic effect. Methyl palmitate prevents bleomycin-induced lung inflammation and fibrosis in rats, by inhibiting NF-κB . Methyl palmitate also prevents CCl4-induced liver fibrosis linked to reduced TGF-β .