Kavain
- Product Name
- Kavain
- CAS No.
- 3155-48-4
- Chemical Name
- Kavain
- Synonyms
- KAWAIN;Kavain;DL-KAWAIN;DL-KAVAIN;(+)-KAVAIN;rac-Kavain;(±)-Kavain;Kawain, DL-;KAVAIN, DL-;METHYSTICIN(P)
- CBNumber
- CB9738874
- Molecular Formula
- C14H14O3
- Formula Weight
- 230.26
- MOL File
- 3155-48-4.mol
Kavain Property
- Melting point:
- 142-148 °C
- Boiling point:
- 432.6±45.0 °C(Predicted)
- Density
- 1.15±0.1 g/cm3(Predicted)
- storage temp.
- Amber Vial, -20°C Freezer, Under inert atmosphere
- solubility
- Chloroform (Slightly), Ethyl Acetate (Slightly)
- form
- Solid
- color
- Off-White to Pale Yellow
- BRN
- 177877
- Stability:
- Light and Moisture Sensitive
- Major Application
- food and beverages
- InChI
- InChI=1S/C14H14O3/c1-16-13-9-12(17-14(15)10-13)8-7-11-5-3-2-4-6-11/h2-8,10,12H,9H2,1H3/b8-7+
- InChIKey
- XEAQIWGXBXCYFX-BQYQJAHWSA-N
- SMILES
- C1(=O)OC(/C=C/C2=CC=CC=C2)CC(OC)=C1
- LogP
- 1.690 (est)
- CAS DataBase Reference
- 3155-48-4(CAS DataBase Reference)
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H302Harmful if swallowed
H315Causes skin irritation
H319Causes serious eye irritation
H335May cause respiratory irritation
- Precautionary statements
-
P261Avoid breathing dust/fume/gas/mist/vapours/spray.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
N-Bromosuccinimide Price
- Product number
- K145490
- Product name
- rac-Kavain
- Packaging
- 5g
- Price
- $2120
- Updated
- 2021/12/16
- Product number
- FK65645
- Product name
- DL-Kawain
- Packaging
- 100mg
- Price
- $55
- Updated
- 2021/12/16
- Product number
- FK65645
- Product name
- DL-Kawain
- Packaging
- 250mg
- Price
- $125
- Updated
- 2021/12/16
- Product number
- FK65645
- Product name
- DL-Kawain
- Packaging
- 500mg
- Price
- $200
- Updated
- 2021/12/16
- Product number
- 9618AF
- Product name
- DL-Kavain
- Packaging
- 250mg
- Price
- $218
- Updated
- 2021/12/16
Kavain Chemical Properties,Usage,Production
Chemical Properties
White crystalline powder, soluble in organic solvents such as methanol, ethanol, and DMSO, derived from Kava Piper methysticum.
Uses
anticonvulsant, analgesic, anxiolytic, suppreses excitatory postsynaptic potential
Uses
rac-Kavain is the main kavalactone found in the roots of the kava plant. Kavain is known to exhibit anticonvulsive properties by attenuating vascular smooth muscle contraction through interactions with voltage-dependent sodium and calcium channels. rac-Kavain was shown in recent research to exhibit protective properties on anaerobic glycolysis, ATP content and intracellular calcium and sodium of anoxic brain vesicles.
Definition
ChEBI: DL-kavain is https://www.chemicalbook.com/ProductChemicalPropertiesCB9738874_EN.htm It has a role as a glycine receptor antagonist.
Synthesis Reference(s)
The Journal of Organic Chemistry, 41, p. 4070, 1976 DOI: 10.1021/jo00888a004
Synthesis
A method for isolation and purification of Kavain, the method comprising the steps of: (1) Pre-treatment of raw herbs: take Cava pepper and dry it at low temperature, and pulverize it into coarse powder; (2) Supercritical extraction: put the crude powder of medicinal herbs into the extraction kettle for extraction, the extraction conditions are: pressure 18-30MPa, temperature 30-45 ??, time for 2-4 hours, and then the pressure is 4-8MPa, temperature 40-50 ?? under the resolution; (3) Column chromatography: take out the extract, heat water dispersion and add the macroporous adsorbent resin column adsorption, flow rate of 1-3BV/h, first 3 times the volume of the column 30% ethanol elution, and then 5 times the volume of the column of 50% -80% ethanol elution, collection of 50% -80% ethanol eluent; (4) decolorization: the eluent is added with activated carbon, the amount added is 1-5% of the volume of the eluent; (5) crystallization: decolorized liquid concentrated under reduced pressure precipitation crystal, crude crystal and then ethanol - ethyl acetate (1:1) heating to dissolve, refrigerated crystals, crystals drying drunken pepper pigment.
Kavain Preparation Products And Raw materials
Raw materials
Preparation Products
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View Lastest Price from Kavain manufacturers
- Product
- Kavain 3155-48-4
- Price
- US $0.00-0.00/g/Bag
- Min. Order
- 10g/Bag
- Purity
- 98% up
- Supply Ability
- 20 tons
- Release date
- 2024-06-27
- Product
- Kavain 3155-48-4
- Price
- US $0.00/kg
- Min. Order
- 1kg
- Purity
- 99.8%
- Supply Ability
- 1000 kg
- Release date
- 2024-04-15
- Product
- Kavain 3155-48-4
- Price
- US $1.00/Kg
- Min. Order
- 1Kg
- Purity
- 98%
- Supply Ability
- 20T
- Release date
- 2024-07-08