1-(TERT-BUTOXYCARBONYL)-3-FLUOROPYRROLIDINE-3-CARBOXYLIC ACID
- Product Name
- 1-(TERT-BUTOXYCARBONYL)-3-FLUOROPYRROLIDINE-3-CARBOXYLIC ACID
- CAS No.
- 1001754-59-1
- Chemical Name
- 1-(TERT-BUTOXYCARBONYL)-3-FLUOROPYRROLIDINE-3-CARBOXYLIC ACID
- Synonyms
- 1-Boc-3-fluoropyrrolidine-3-carboxylic acid;1-Boc-3-fluoropyrrolidine-3-carboxylic acid - [F14430];1-(TERT-BUTOXYCARBONYL)-3-FLUOROPYRROLIDINE-3-CARBOXYLIC ACID;1-[(tert-butoxy)carbonyl]-3-fluoropyrrolidine-3-carboxylic a...;1,3-Pyrrolidinedicarboxylic acid, 3-fluoro-, 1-(1,1-dimethylethyl) ester;3-FLUORO-1-[(2-METHYLPROPAN-2-YL)OXYCARBONYL]PYRROLIDINE-3-CARBOXYLIC ACID
- CBNumber
- CB7787227
- Molecular Formula
- C10H16FNO4
- Formula Weight
- 233.24
- MOL File
- Mol file
1-(TERT-BUTOXYCARBONYL)-3-FLUOROPYRROLIDINE-3-CARBOXYLIC ACID Property
- Melting point:
- 140-142 °C
- Boiling point:
- 330℃
- Density
- 1.25
- Flash point:
- 153℃
- storage temp.
- 2-8°C
- pka
- 2.38±0.20(Predicted)
- Appearance
- White to off-white Solid
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H302Harmful if swallowed
H315Causes skin irritation
H319Causes serious eye irritation
H335May cause respiratory irritation
- Precautionary statements
-
P261Avoid breathing dust/fume/gas/mist/vapours/spray.
P280Wear protective gloves/protective clothing/eye protection/face protection.
P301+P312IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.
P302+P352IF ON SKIN: wash with plenty of soap and water.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
N-Bromosuccinimide Price
- Product number
- D6507
- Product name
- 1-(tert-Butoxycarbonyl)-3-fluoropyrrolidine-3-carboxylic Acid
- Purity
- min. 98.0 %
- Packaging
- 200MG
- Price
- $192
- Updated
- 2025/07/31
- Product number
- B810953
- Product name
- 1-(tert-Butoxycarbonyl)-3-fluoropyrrolidine-3-carboxylicAcid
- Packaging
- 50mg
- Price
- $130
- Updated
- 2021/12/16
- Product number
- 4918AQ
- Product name
- 3-fluoro-1-[(2-methylpropan-2-yl)oxycarbonyl]pyrrolidine-3-carboxylicacid
- Packaging
- 100mg
- Price
- $201.2
- Updated
- 2021/12/16
- Product number
- F14430
- Product name
- 1-Boc-3-fluoropyrrolidine-3-carboxylicacid
- Purity
- 97.0%
- Packaging
- 1g
- Price
- $460
- Updated
- 2021/12/16
- Product number
- HCH0062288
- Product name
- 1-(TERT-BUTOXYCARBONYL)-3-FLUOROPYRROLIDINE-3-CARBOXYLIC ACID
- Purity
- 95.00%
- Packaging
- 1G
- Price
- $722.4
- Updated
- 2021/12/16
1-(TERT-BUTOXYCARBONYL)-3-FLUOROPYRROLIDINE-3-CARBOXYLIC ACID Chemical Properties,Usage,Production
Synthesis
942189-96-0
1001754-59-1
Step 3: 1-tert-butyl 3-methyl 3-fluoropyrrolidine-1,3-dicarboxylate (414.4 mg, 1.676 mmol) was dissolved in a 3:1 THF/MeOH solvent mixture (5.6 mL), and 2.0 M KOH aqueous solution (2.1 mL, 4.19 mmol) was added. The reaction mixture was stirred at room temperature for 2 hours. Upon completion of the reaction, the organic solvent was removed by distillation under reduced pressure. The residue was diluted with 20% isopropanol/dichloromethane (IPA/DCM) mixed solvent and subsequently acidified to pH 3 with 1.0 M aqueous HCl. The resulting mixture was extracted twice with 20% IPA/DCM mixed solvent, the organic phases were combined, washed twice with water, dried over anhydrous sodium sulfate, filtered, and concentrated under reduced pressure to afford 1-(tert-butoxycarbonyl)-3-fluoropyrrolidine-3-carboxylic acid ( 352.8 mg, 90.3% yield). The product was characterized by 1H NMR (400 MHz, DMSO-d6): δ= 13.80 (s, 1H), 3.69-3.54 (m, 3H), 3.36-3.32 (m, 1H), 2.43-2.24 (m, 2H), 1.40 (s, 9H).
References
[1] Patent: WO2013/20062, 2013, A1. Location in patent: Paragraph 00244
[2] Patent: WO2018/178041, 2018, A1. Location in patent: Page/Page column 116; 117
1-(TERT-BUTOXYCARBONYL)-3-FLUOROPYRROLIDINE-3-CARBOXYLIC ACID Preparation Products And Raw materials
Raw materials
Preparation Products
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