1-(TERT-BUTOXYCARBONYL)-3-FLUOROPYRROLIDINE-3-CARBOXYLIC ACID

Product Name: 1-(TERT-BUTOXYCARBONYL)-3-FLUOROPYRROLIDINE-3-CARBOXYLIC ACID
CAS No.: 1001754-59-1
Chemical Name: 1-(TERT-BUTOXYCARBONYL)-3-FLUOROPYRROLIDINE-3-CARBOXYLIC ACID
Synonyms: 1-Boc-3-fluoropyrrolidine-3-carboxylic acid;1-Boc-3-fluoropyrrolidine-3-carboxylic acid - [F14430];1-(TERT-BUTOXYCARBONYL)-3-FLUOROPYRROLIDINE-3-CARBOXYLIC ACID;1-[(tert-butoxy)carbonyl]-3-fluoropyrrolidine-3-carboxylic a...;1,3-Pyrrolidinedicarboxylic acid, 3-fluoro-, 1-(1,1-dimethylethyl) ester;3-FLUORO-1-[(2-METHYLPROPAN-2-YL)OXYCARBONYL]PYRROLIDINE-3-CARBOXYLIC ACID
CBNumber: CB7787227
Molecular Formula: C10H16FNO4
Formula Weight: 233.24
MOL File: Mol file

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1-(TERT-BUTOXYCARBONYL)-3-FLUOROPYRROLIDINE-3-CARBOXYLIC ACID Property

Melting point:: 140-142 °C
Boiling point:: 330℃
Density: 1.25
Flash point:: 153℃
storage temp.: 2-8°C
pka: 2.38±0.20(Predicted)
Appearance: White to off-white Solid

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H302Harmful if swallowed

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P301+P312IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.

P302+P352IF ON SKIN: wash with plenty of soap and water.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

TCI Chemical

Product number: D6507
Product name: 1-(tert-Butoxycarbonyl)-3-fluoropyrrolidine-3-carboxylic Acid
Purity: min. 98.0 %
Packaging: 200MG
Price: $192
Updated: 2025/07/31

TRC

Product number: B810953
Product name: 1-(tert-Butoxycarbonyl)-3-fluoropyrrolidine-3-carboxylicAcid
Packaging: 50mg
Price: $130
Updated: 2021/12/16

AK Scientific

Product number: 4918AQ
Product name: 3-fluoro-1-[(2-methylpropan-2-yl)oxycarbonyl]pyrrolidine-3-carboxylicacid
Packaging: 100mg
Price: $201.2
Updated: 2021/12/16

Synthonix

Product number: F14430
Product name: 1-Boc-3-fluoropyrrolidine-3-carboxylicacid
Purity: 97.0%
Packaging: 1g
Price: $460
Updated: 2021/12/16

American Custom Chemicals Corporation

Product number: HCH0062288
Product name: 1-(TERT-BUTOXYCARBONYL)-3-FLUOROPYRROLIDINE-3-CARBOXYLIC ACID
Purity: 95.00%
Packaging: 1G
Price: $722.4
Updated: 2021/12/16

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1-(TERT-BUTOXYCARBONYL)-3-FLUOROPYRROLIDINE-3-CARBOXYLIC ACID Chemical Properties,Usage,Production

Synthesis

942189-96-0

1001754-59-1

Step 3: 1-tert-butyl 3-methyl 3-fluoropyrrolidine-1,3-dicarboxylate (414.4 mg, 1.676 mmol) was dissolved in a 3:1 THF/MeOH solvent mixture (5.6 mL), and 2.0 M KOH aqueous solution (2.1 mL, 4.19 mmol) was added. The reaction mixture was stirred at room temperature for 2 hours. Upon completion of the reaction, the organic solvent was removed by distillation under reduced pressure. The residue was diluted with 20% isopropanol/dichloromethane (IPA/DCM) mixed solvent and subsequently acidified to pH 3 with 1.0 M aqueous HCl. The resulting mixture was extracted twice with 20% IPA/DCM mixed solvent, the organic phases were combined, washed twice with water, dried over anhydrous sodium sulfate, filtered, and concentrated under reduced pressure to afford 1-(tert-butoxycarbonyl)-3-fluoropyrrolidine-3-carboxylic acid ( 352.8 mg, 90.3% yield). The product was characterized by 1H NMR (400 MHz, DMSO-d6): δ= 13.80 (s, 1H), 3.69-3.54 (m, 3H), 3.36-3.32 (m, 1H), 2.43-2.24 (m, 2H), 1.40 (s, 9H).

References

[1] Patent: WO2013/20062, 2013, A1. Location in patent: Paragraph 00244
[2] Patent: WO2018/178041, 2018, A1. Location in patent: Page/Page column 116; 117

1-(TERT-BUTOXYCARBONYL)-3-FLUOROPYRROLIDINE-3-CARBOXYLIC ACID Preparation Products And Raw materials

Raw materials

Preparation Products

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1-(TERT-BUTOXYCARBONYL)-3-FLUOROPYRROLIDINE-3-CARBOXYLIC ACID Suppliers

China 48 France 1 India 1 Ukraine 1 United Kingdom 1 United States 10 Global 62

Aladdin Scientific

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1001754-59-1, 1-(TERT-BUTOXYCARBONYL)-3-FLUOROPYRROLIDINE-3-CARBOXYLIC ACIDRelated Search:

(R)-1-(tert-butoxycarbonyl)-3-fluoropyrrolidine-3-carboxylic acid 1,3-Pyrrolidinedicarboxylic acid, 3-fluoro-, 1-(9H-fluoren-9-ylmethyl) ester (3S)-1-[(tert-butoxy)carbonyl]-3-fluoropyrrolidine-3-carboxylic acid

1-(TERT-BUTOXYCARBONYL)-3-FLUOROPYRROLIDINE-3-CARBOXYLIC ACID

1-Boc-3-fluoropyrrolidine-3-carboxylic acid

1,3-Pyrrolidinedicarboxylic acid, 3-fluoro-, 1-(1,1-dimethylethyl) ester

3-FLUORO-1-[(2-METHYLPROPAN-2-YL)OXYCARBONYL]PYRROLIDINE-3-CARBOXYLIC ACID

1-[(tert-butoxy)carbonyl]-3-fluoropyrrolidine-3-carboxylic a...

1-Boc-3-fluoropyrrolidine-3-carboxylic acid - [F14430]

1001754-59-1