Ly93

Product Name: Ly93
CAS No.: 1883528-69-5
Chemical Name: Ly93
Synonyms: Ly93;Ly93,Ly-93;SMS2-IN-Ly93;Ly93, 10 mM in DMSO;Benzamide, 2-[(2-ethylphenyl)methoxy]-N-3-pyridinyl-;2-[(2-ethylphenyl)methoxy]-N-(pyridin-3-yl)benzamide
CBNumber: CB78054633
Molecular Formula: C21H20N2O2
Formula Weight: 332.4
MOL File: 1883528-69-5.mol

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Ly93 Property

Boiling point:: 450.6±35.0 °C(Predicted)
Density: 1.191±0.06 g/cm3(Predicted)
storage temp.: Store at -20°C
solubility: DMSO : 250 mg/mL (752.11 mM; Need ultrasonic)
pka: 12.67±0.70(Predicted)
form: Solid
color: Off-white to light yellow

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P302+P352IF ON SKIN: wash with plenty of soap and water.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

P321Specific treatment (see … on this label).

P332+P313IF SKIN irritation occurs: Get medical advice/attention.

P362Take off contaminated clothing and wash before reuse.

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Ly93 Chemical Properties,Usage,Production

Biological Activity

Ly93 is a selective and orally active sphingomyelin synthase 2 (SMS2) inhibitor, with an IC50 of 91 nM[1]. Ly93 (100 mg/kg, i.g. once daily for 7 days) significantly decreases the plasma SM levels of C57BL/6J mice[1].Ly93 dose-dependently attenuates the atherosclerotic lesions in the root and the entire aorta as well as macrophage content in lesions, in apolipoprotein E gene knockout mice[1].

References

[1]. Li Y, et al. Discovery, synthesis and anti-atherosclerotic activities of a novel selective sphingomyelin synthase 2 inhibitor. Eur J Med Chem. 2019 Feb 1;163:864-882.

Ly93 Preparation Products And Raw materials

Raw materials

Preparation Products

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Ly93 Suppliers

China 15 United States 2 Global 17

Shanghai EFE Biological Technology Co., Ltd.

Tel: 021-65675885 18964387627
Fax: 021-65675885
Email: info@efebio.com
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ProdList: 9805
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TargetMol Chemicals Inc.

Tel: +1-781-999-5354 +1-00000000000
Email: marketing@targetmol.com
Country: United States
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ChemeGen(Shanghai) Biotechnology Co.,Ltd.

Tel: 18818260767
Fax: QQ 3610331285
Email: sales@chemegen.com
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Nanjing Shizhou Biology Technology Co.,Ltd

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ShangHai ChuanQian Chemcial Technique Centre

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Changzhou Furuisi Biotechnology Co., Ltd

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Jinan Jiuli Biotechnology Co. , Ltd.

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Nantong Hi-Future Biotechnology Co., Ltd

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Email: sales@chemhifuture.com
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Nanjing Shizhou Biology Technology Co.,Ltd

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TargetMol Chemicals Inc.

Tel: 4008200310
Email: marketing@tsbiochem.com
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1883528-69-5, Ly93Related Search:

Ly93

SMS2-IN-Ly93

2-[(2-ethylphenyl)methoxy]-N-(pyridin-3-yl)benzamide

Ly93,Ly-93

Benzamide, 2-[(2-ethylphenyl)methoxy]-N-3-pyridinyl-

Ly93, 10 mM in DMSO

1883528-69-5