Ly93

Product Name: Ly93
CAS No.: 1883528-69-5
Chemical Name: Ly93
Synonyms: Ly93;Ly93,Ly-93;SMS2-IN-Ly93;Ly93, 10 mM in DMSO;2-((2-Ethylbenzyl)oxy)-N-(pyridin-3-yl)benzamide;Benzamide, 2-[(2-ethylphenyl)methoxy]-N-3-pyridinyl-;2-[(2-ethylphenyl)methoxy]-N-(pyridin-3-yl)benzamide
CBNumber: CB78054633
Molecular Formula: C21H20N2O2
Formula Weight: 332.4
MOL File: 1883528-69-5.mol

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Ly93 Property

Boiling point:: 450.6±35.0 °C(Predicted)
Density: 1.191±0.06 g/cm3(Predicted)
storage temp.: Store at -20°C
solubility: DMSO : 250 mg/mL (752.11 mM; Need ultrasonic)
pka: 12.67±0.70(Predicted)
form: Solid
color: Off-white to light yellow

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P302+P352IF ON SKIN: wash with plenty of soap and water.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

P321Specific treatment (see … on this label).

P332+P313IF SKIN irritation occurs: Get medical advice/attention.

P362Take off contaminated clothing and wash before reuse.

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Ly93 Chemical Properties,Usage,Production

Uses

Ly93 is a selective and orally active sphingomyelin synthase 2 (SMS2) inhibitor, with an IC50 of 91 nM[1].

Biological Activity

Ly93 is a selective and orally active sphingomyelin synthase 2 (SMS2) inhibitor, with an IC50 of 91 nM[1]. Ly93 (100 mg/kg, i.g. once daily for 7 days) significantly decreases the plasma SM levels of C57BL/6J mice[1].Ly93 dose-dependently attenuates the atherosclerotic lesions in the root and the entire aorta as well as macrophage content in lesions, in apolipoprotein E gene knockout mice[1].

in vivo

Ly93 (100 mg/kg, i.g. once daily for 7 days) significantly decreases the plasma SM levels of C57BL/6J mice^[1].
Ly93 dose-dependently attenuates the atherosclerotic lesions in the root and the entire aorta as well as macrophage content in lesions, in apolipoprotein E gene knockout mice^[1].

Animal Model:	C57BL/6J mice^[1].
Dosage:	100 mg/kg.
Administration:	I.G. (gavage) once daily for 7 days.
Result:	Significantly decreased the plasma SM levels compared with vehicle group.

Animal Model:	ApoE KO mice (eight-week-old)^[1].
Dosage:	12.5 or 40 mg/kg.
Administration:	I.G. (gavage) once daily.
Result:	The levels of ALT and AST in the plasma of apoE KO mice did not show statistic changes when compared with the control group.

References

[1]. Li Y, et al. Discovery, synthesis and anti-atherosclerotic activities of a novel selective sphingomyelin synthase 2 inhibitor. Eur J Med Chem. 2019 Feb 1;163:864-882.

Ly93 Preparation Products And Raw materials

Raw materials

Preparation Products

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Ly93 Suppliers

China 30 United States 2 Global 32

Shanghai Lollane Biological Technology Co.,Ltd.

Tel: 021-52996696，15000506266 15000506266
Fax: +86-21-52996696
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Shanghai EFE Biological Technology Co., Ltd.

Tel: 021-65675885 18964387627
Fax: 021-65675885
Email: info@efebio.com
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Shanghai YuanYe Biotechnology Co., Ltd.

Tel: 021-61312847; 18021002903
Fax: QQ:3008007432
Email: 3008007409@qq.com
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Shanghai Rechem science Co., Ltd.

Tel: 021-31433387 15618786686
Fax: QQ:1369748377
Email: sales@rechemscience.com
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Shanghai Chaolan Chemical Technology Center

Tel: 021-QQ：65489617 15618227136
Fax: 21-5161 9052
Email: Sales@ATKchemical.com
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TargetMol Chemicals Inc.

Tel: +1-781-999-5354; +17819995354
Email: marketing@targetmol.com
Country: United States
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Changzhou Chenhong Biotechnology Co., Ltd.

Tel: +86-0519-85788828 +86-13775037613
Email: sales@chemrenpharm.com
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ChemeGen(Shanghai) Biotechnology Co.,Ltd.

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Nanjing Shizhou Biology Technology Co.,Ltd

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ShangHai ChuanQian Chemcial Technique Centre

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1883528-69-5, Ly93Related Search:

Ly93

SMS2-IN-Ly93

2-[(2-ethylphenyl)methoxy]-N-(pyridin-3-yl)benzamide

Ly93,Ly-93

Benzamide, 2-[(2-ethylphenyl)methoxy]-N-3-pyridinyl-

Ly93, 10 mM in DMSO

2-((2-Ethylbenzyl)oxy)-N-(pyridin-3-yl)benzamide

1883528-69-5