Otelixizumab

Product Name: Otelixizumab
CAS No.: 881191-44-2
Chemical Name: Otelixizumab
Synonyms: Otelixizumab;Otelixizumab (anti-CD3);Research Grade Otelixizumab;Research Grade Otelixizumab(DHC27702)
CBNumber: CB78080780
Formula Weight: 0
MOL File: Mol file

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Otelixizumab Property

form: Liquid
color: Colorless to light yellow

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Hazard and Precautionary Statements (GHS)

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Otelixizumab Chemical Properties,Usage,Production

Uses

Otelixizumab (ChAglyCD3) is an anti-human CD3 monoclonal antibody and can be used for the research of type 1 diabetes[1].

in vivo

Otelixizumab (ChAglyCD3) (100 μg/mouse; i.v.; once) results in durable disease remission dependent on transferable T cell–mediated tolerance in diabetic transgenic mice^[1].

Animal Model:	BALB/c-huCD3e mice carrying the human CD3e chain^[1]
Dosage:	100 μg/mouse
Administration:	Intravenous injection, once
Result:	Induced secretion of lower amounts of IL-6. Exhibited up-regulation of regulatory T cells.

References

[1] Kuhn C, et al. Human CD3 transgenic mice: preclinical testing of antibodies promoting immune tolerance. Sci Transl Med. 2011 Feb 2;3(68):68ra10. DOI:10.1126/scitranslmed.3001830
[2] Guglielmi C, et al. Efficacy and safety of otelixizumab use in new-onset type 1 diabetes mellitus. Expert Opin Biol Ther. 2016 Jun;16(6):841-6. DOI:10.1080/14712598.2016.1180363

Otelixizumab Preparation Products And Raw materials

Raw materials

Preparation Products

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Otelixizumab Suppliers

China 20 United States 1 Global 21

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881191-44-2, OtelixizumabRelated Search:

Balstilimab Volociximab Nurulimab Manelimab Adecatumumab Frovocimab Cofetuzumab Theralizumab Ranibizumab Andecaliximab

Otelixizumab

Research Grade Otelixizumab(DHC27702)

Otelixizumab (anti-CD3)

Research Grade Otelixizumab

881191-44-2