ChemicalBook > CAS DataBase List > Otelixizumab
Otelixizumab
- Product Name
- Otelixizumab
- CAS No.
- 881191-44-2
- Chemical Name
- Otelixizumab
- Synonyms
- Otelixizumab;Otelixizumab (anti-CD3);Research Grade Otelixizumab;Research Grade Otelixizumab(DHC27702)
- CBNumber
- CB78080780
- Formula Weight
- 0
- MOL File
- Mol file
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Otelixizumab Property
- form
- Liquid
- color
- Colorless to light yellow
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Otelixizumab Chemical Properties,Usage,Production
Uses
Otelixizumab (ChAglyCD3) is an anti-human CD3 monoclonal antibody and can be used for the research of type 1 diabetes[1].
in vivo
Otelixizumab (ChAglyCD3) (100 μg/mouse; i.v.; once) results in durable disease remission dependent on transferable T cell–mediated tolerance in diabetic transgenic mice[1].
| Animal Model: | BALB/c-huCD3e mice carrying the human CD3e chain[1] |
| Dosage: | 100 μg/mouse |
| Administration: | Intravenous injection, once |
| Result: | Induced secretion of lower amounts of IL-6. Exhibited up-regulation of regulatory T cells. |
References
[1] Kuhn C, et al. Human CD3 transgenic mice: preclinical testing of antibodies promoting immune tolerance. Sci Transl Med. 2011 Feb 2;3(68):68ra10. DOI:10.1126/scitranslmed.3001830
[2] Guglielmi C, et al. Efficacy and safety of otelixizumab use in new-onset type 1 diabetes mellitus. Expert Opin Biol Ther. 2016 Jun;16(6):841-6. DOI:10.1080/14712598.2016.1180363
Otelixizumab Preparation Products And Raw materials
Raw materials
Preparation Products
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Otelixizumab Suppliers
- Tel
- tp@aladdinsci.com
- Country
- United States
- ProdList
- 57505
- Advantage
- 58
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