Lutikizumab

Product Name: Lutikizumab
CAS No.: 1791411-57-8
Chemical Name: Lutikizumab
Synonyms: Lutikizumab;Research Grade Lutikizumab
CBNumber: CB78080997
Formula Weight: 0
MOL File: Mol file

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Lutikizumab Property

form: Liquid
color: Colorless to light yellow

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Hazard and Precautionary Statements (GHS)

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Lutikizumab Chemical Properties,Usage,Production

Uses

Lutikizumab (ABT-981) is an anti-IL-1α and IL-1β dual variable domain immunoglobulin. Lutikizumab binds and inhibits IL-1α and IL-1β. Lutikizumab can be used for the research of osteoarthritis[1].

in vivo

Lutikizumab (0.0001-1 mg/kg, i.p., once) shows effective inhibition to the IL-6 production induced by IL-1α and IL-1β^[1].

Animal Model:	Female C57/BL6 mice with IL-1α and IL-1β injection^[1]
Dosage:	0.0001-1 mg/kg
Administration:	Intraperitoneal injection, 0.0001-1 mg/kg, once
Result:	Dose-dependently decreased the murine IL-6 generated by human and cynomolgus IL-1α and IL-1β.

References

[1] Lacy SE, et al. Generation and characterization of ABT-981, a dual variable domain immunoglobulin (DVD-Ig(TM)) molecule that specifically and potently neutralizes both IL-1α and IL-1β. MAbs. 2015;7(3):605-19. DOI:10.1080/19420862.2015.1026501

Lutikizumab Preparation Products And Raw materials

Raw materials

Preparation Products

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Lutikizumab Suppliers

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1791411-57-8, LutikizumabRelated Search:

Timolumab Flanvotumab Lodapolimab Immunoglobulin G1,anti-(human NCA-90 granulocyte cell antigen) (mouse monoclonal IMMU-MN3 g1-chain), disulfide with mousemonoclonal IMMU-MN3 k-chain, dimer (9CI) Cadonilimab Solitomab Dovanvetmab Birtamimab Edobacomab Prolgolimab

Lutikizumab

Research Grade Lutikizumab

1791411-57-8