TERT-BUTYL 3-BROMO-1H-PYRROLO[2,3-B]PYRIDINE-1-CARBOXYLATE

Product Name: TERT-BUTYL 3-BROMO-1H-PYRROLO[2,3-B]PYRIDINE-1-CARBOXYLATE
CAS No.: 226085-17-2
Chemical Name: TERT-BUTYL 3-BROMO-1H-PYRROLO[2,3-B]PYRIDINE-1-CARBOXYLATE
Synonyms: 1-Boc-3-bromo-7-azaindole;3-Bromo-1H-pyrrolo[2,3-b]pyridine, N-BOC protected;3-Bromo-1H-pyrrolo[2,3-b]pyridine, N1-BOC protected;tert-Butyl 3-broMopyrrolo[2,3-b]pyridine-1-carboxylate;TERT-BUTYL 3-BROMO-1H-PYRROLO[2,3-B]PYRIDINE-1-CARBOXYLAT;TERT-BUTYL 3-BROMO-1H-PYRROLO[2,3-B]PYRIDINE-1-CARBOXYLATE;1H-Pyrrolo[2,3-b]pyridine-1-carboxylic acid,3-bromo-, 1,1-dimethylethyl ester;tert-Butyl 3-bromo-1H-pyrrolo[2,3-b]pyridine-1-carboxylate, 3-Bromo-1-(tert-butoxycarbonyl)-1H-pyrrolo[2,3-b]pyridine
CBNumber: CB7808562
Molecular Formula: C12H13BrN2O2
Formula Weight: 297.15
MOL File: 226085-17-2.mol

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TERT-BUTYL 3-BROMO-1H-PYRROLO[2,3-B]PYRIDINE-1-CARBOXYLATE Property

Boiling point:: 376.7±45.0 °C(Predicted)
Density: 1.46±0.1 g/cm3(Predicted)
storage temp.: under inert gas (nitrogen or Argon) at 2-8°C
pka: 1.65±0.30(Predicted)
Appearance: Light yellow to yellow Liquid

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Safety

Hazard Codes: Xi
HazardClass: IRRITANT
HS Code: 2933399990

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H302Harmful if swallowed

H315Causes skin irritation

H319Causes serious eye irritation

H332Harmful if inhaled

H335May cause respiratory irritation

Precautionary statements

P280Wear protective gloves/protective clothing/eye protection/face protection.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

P310Immediately call a POISON CENTER or doctor/physician.

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N-Bromosuccinimide Price

TRC

Product number: T135578
Product name: tert-Butyl3-Bromo-1H-pyrrolo[2,3-b]pyridine-1-carboxylate
Packaging: 500mg
Price: $200
Updated: 2021/12/16

Biosynth Carbosynth

Product number: FB154069
Product name: tert-Butyl 3-bromopyrrolo[2,3-b]pyridine-1-carboxylate
Packaging: 500mg
Price: $75
Updated: 2021/12/16

Matrix Scientific

Product number: 047090
Product name: tert-Butyl 3-bromo-1H-pyrrolo[2,3-b]pyridine-1-carboxylate
Purity: >95%
Packaging: 500mg
Price: $80
Updated: 2021/12/16

Matrix Scientific

Product number: 047090
Product name: tert-Butyl 3-bromo-1H-pyrrolo[2,3-b]pyridine-1-carboxylate
Purity: >95%
Packaging: 1g
Price: $107
Updated: 2021/12/16

Biosynth Carbosynth

Product number: FB154069
Product name: tert-Butyl 3-bromopyrrolo[2,3-b]pyridine-1-carboxylate
Packaging: 1g
Price: $131
Updated: 2021/12/16

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TERT-BUTYL 3-BROMO-1H-PYRROLO[2,3-B]PYRIDINE-1-CARBOXYLATE Chemical Properties,Usage,Production

Synthesis

74420-15-8

24424-99-5

226085-17-2

Under nitrogen atmosphere, 3-bromo-1H-pyrrolo[2,3-b]pyridine (0.10 g, 0.50 mmol) was dissolved in tetrahydrofuran (THF, 4.0 mL) followed by the addition of 4-dimethylaminopyridine (DMAP, 0.006 g, 0.06 mmol). The reaction mixture was cooled to -20 °C and di-tert-butyl dicarbonate (Boc anhydride, 122 μL, 0.56 mmol) was slowly added. The reaction mixture was gradually warmed to room temperature and stirred continuously for 2 hours. The reaction progress was monitored by thin layer chromatography (TLC). Upon completion of the reaction, water (20 mL) was added to the mixture and extracted with ethyl acetate (EtOAc, 3 × 50 mL). The organic phases were combined, dried with anhydrous sodium sulfate (Na2SO4), filtered and concentrated. The crude product was purified by silica gel column chromatography (60-120 mesh, 5% ethyl acetate-hexane as eluent) to afford the target product 1-BOC-3-bromo-7-azaindole as an oil (0.12 g, 79% yield).

References

[1] Synthesis, 1999, # 4, p. 615 - 620
[2] Patent: WO2009/74812, 2009, A1. Location in patent: Page/Page column 59

TERT-BUTYL 3-BROMO-1H-PYRROLO[2,3-B]PYRIDINE-1-CARBOXYLATE Preparation Products And Raw materials

Raw materials

Preparation Products

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TERT-BUTYL 3-BROMO-1H-PYRROLO[2,3-B]PYRIDINE-1-CARBOXYLATE Suppliers

China 67 Germany 1 India 1 United Kingdom 3 United States 9 Global 81

Carbosynth

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Apollo Scientific Ltd.

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Key Organics Limited/Bionet Research

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View Lastest Price from TERT-BUTYL 3-BROMO-1H-PYRROLO[2,3-B]PYRIDINE-1-CARBOXYLATE manufacturers

Career Henan Chemical Co

Product: tert-butyl 3-bromopyrrolo[2,3-b]pyridine-1-carboxylate 226085-17-2
Price: US $1.00/KG
Min. Order: 1KG
Purity: 99%
Supply Ability: 200kg
Release date: 2020-01-09

226085-17-2, TERT-BUTYL 3-BROMO-1H-PYRROLO[2,3-B]PYRIDINE-1-CARBOXYLATERelated Search:

1-METHYL-3-BROMO-7-AZAINDOLE 3-Bromo-7-azaindole 1-Boc-7-azaindole TERT-BUTYL 3-BROMO-1H-PYRROLO[2,3-B]PYRIDINE-1-CARBOXYLATE tert-butyl 3-broMo-6,7-dihydropyrazolo[1,5-a]pyrazine-5(4H)-carboxylate 1-Boc-3-bromo-6-methylindole 3-BROMOINDOLE-1-CARBOXYLIC ACID TERT-BUTYL ESTER 3-FORMYL-4-HYDROXYINDOLE-1-CARBOXYLIC ACID TERT-BUTYL ESTER

TERT-BUTYL 3-BROMO-1H-PYRROLO[2,3-B]PYRIDINE-1-CARBOXYLATE

3-Bromo-1H-pyrrolo[2,3-b]pyridine, N-BOC protected

1H-Pyrrolo[2,3-b]pyridine-1-carboxylic acid,3-bromo-, 1,1-dimethylethyl ester

1-Boc-3-bromo-7-azaindole

3-Bromo-1H-pyrrolo[2,3-b]pyridine, N1-BOC protected

tert-Butyl 3-bromo-1H-pyrrolo[2,3-b]pyridine-1-carboxylate, 3-Bromo-1-(tert-butoxycarbonyl)-1H-pyrrolo[2,3-b]pyridine

tert-Butyl 3-broMopyrrolo[2,3-b]pyridine-1-carboxylate

TERT-BUTYL 3-BROMO-1H-PYRROLO[2,3-B]PYRIDINE-1-CARBOXYLAT

226085-17-2

138343-77-9

Heterocycle-Pyridine series