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Ensifentrine

Product Name
Ensifentrine
CAS No.
1884461-72-6
Chemical Name
Ensifentrine
Synonyms
Ensifentrine;(E)-RPL-554;Ensifentrina;Ensifentrinum;Ensifentrine ( RPL554 );Ensifentrine, 10 mM in DMSO;EnsifentrineQ: What is Ensifentrine Q: What is the CAS Number of Ensifentrine;(E)-1-(2-(2-(Mesitylimino)-9,10-dimethoxy-4-oxo-6,7-dihydro-2H-pyrimido[6,1-a]isoquinolin-3(4H)-yl)ethyl)urea;N-[2-[(2E)-6,7-dihydro-9,10-dimethoxy-4-oxo-2-[(2,4,6-trimethylphenyl)imino]-2H-pyrimido[6,1-a]isoquinolin-3(4H)-yl]ethyl]-;(E)-1-(2-(2-(Mesitylimino)-9,10-dimethoxy-4-oxo-6,7-dihydro-2H-pyrimido[6,1-a]isoquinolin-3(4H)-yl)ethyl)urea , Ensifentrine
CBNumber
CB78138104
Molecular Formula
C26H31N5O4
Formula Weight
477.56
MOL File
1884461-72-6.mol
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Ensifentrine Property

Density 
1.29±0.1 g/cm3(Predicted)
storage temp. 
Store at -20°C
solubility 
DMSO : 25 mg/mL (52.35 mM; Need ultrasonic)
form 
Solid
pka
13.73±0.46(Predicted)
color 
Light yellow to green yellow
InChIKey
CSOBIBXVIYAXFM-BYNJWEBRSA-N
SMILES
N(CCN1/C(=N/C2=C(C)C=C(C)C=C2C)/C=C2C3=C(C=C(OC)C(OC)=C3)CCN2C1=O)C(N)=O
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Hazard and Precautionary Statements (GHS)

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Ensifentrine Chemical Properties,Usage,Production

Uses

RPL 554 is a known drug candidate for respiratory diseases, particularly in patients with asthma or chronic obstructive pulmonary diseases.

in vivo

Ensifentrine (RPL-554; 10 mg/kg; Oral administration; once) significantly inhibits eosinophil recruitment following antigen challenge in ovalbumin-sensitized guinea pigs[1].
The inhalation of dry powder containing Ensifentrine by conscious guinea pigs (25% in micronized lactose) 1.5 h before antigen exposure significantly inhibits the recruitment of eosinophils to the airways[1].
Exposure of conscious guinea pigs to inhalation of dry powder containing Ensifentrine (2.5%) in micronized lactose significantly inhibits histamine-induced plasma protein extravasation in the trachea and histamine-induced bronchoconstriction over a 5.5-h period[1].

Animal Model:Male Dunkin Hartley guinea pigs (200-300 g) injected with ovalbumin[1].
Dosage:10 mg/kg
Administration:Oral administration; once
Result:Significantly inhibits eosinophil recruitment following antigen challenge in ovalbumin-sensitized guinea pigs.

IC 50

PDE3: 0.4 nM (IC50); PDE4: 1479 nM (IC50)

Ensifentrine Preparation Products And Raw materials

Raw materials

Preparation Products

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Ensifentrine Suppliers

China 75 India 1 United States 3 Global 79
Shanghai Hope Chem Co., Ltd.，
Tel
+21-18501659228 18501659228
Fax
sales@hope-chem.com
Email
info@hope-chem.com
Country
China
ProdList
474
Advantage
55
Wuhan HSN Pharmaresearch CO., LTD.
Tel
027-81525288 18086100502
Fax
027-86589137
Email
linwell@126.com
Country
China
ProdList
233
Advantage
50
Taizhou Nanfeng Pharmaceutical Research Institute
Tel
nanfengdrug@163.com; 18616377689
Email
nanfengdrug@163.com
Country
China
ProdList
20009
Advantage
58
Hangzhou Yinghui Industrial Co.,Ltd
Tel
15355417531
Email
2028755477@qq.com
Country
China
ProdList
152
Advantage
58
Fuxin Long Rui Pharmaceutical
Tel
1381-0598707 13683261597
Email
sales3@huikangchem.com
Country
China
ProdList
209
Advantage
58
Z IntellecChem & Tech. Co., Ltd
Tel
15050866711
Fax
QQ:2677337387
Email
contact@zintellec.com
Country
China
ProdList
254
Advantage
58
Nanjing Huarui Biopharmaceutical Technology Co., Ltd.
Tel
18014824111
Email
908320070@qq.com
Country
China
ProdList
65
Advantage
58
WUHAN SUN-SHINE BIO-TECHNOLOGY Co., Ltd.
Tel
17702719238 18971495150;
Email
sales@sun-shinechem.com
Country
China
ProdList
1077
Advantage
64
Nanjing Chemlin Chemical Co., Ltd
Tel
025-83697070
Fax
+86-25-83453306
Email
info@chemlin.com.cn
Country
China
ProdList
16075
Advantage
64
BOC Sciences
Tel
1-631-485-4226; 16314854226
Email
info@bocsci.com
Country
United States
ProdList
12952
Advantage
65
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View Lastest Price from Ensifentrine manufacturers

ZHENGZHOU JIUYI TIME NEW MATERIALS CO,.LTD
Product
Ensifentrine 1884461-72-6
Price
US $2.20-8.80/KG
Min. Order
1KG
Purity
99%
Supply Ability
g-kg-tons
Release date
2025-07-08
Wuhan JiyunZen Tech Co., Ltd.
Product
Ensifentrine 1884461-72-6
Price
US $5.00-0.50/KG
Min. Order
1KG
Purity
99% hplc
Supply Ability
500TONS
Release date
2025-06-05

1884461-72-6, EnsifentrineRelated Search:

2,4,6(1H,3H,5H)-Pyrimidinetrione, 1-(3,4-dimethoxyphenyl)- N-Nitroso Ensifentrine-d6 N-Nitroso Ensifentrine

  • Urea, N-[2-[(2E)-6,7-dihydro-9,10-dimethoxy-4-oxo-2-[(2,4,6-trimethylphenyl)imino]-2H-pyrimido[6,1-a]isoquinolin-3(4H)-yl]ethyl]-
  • Ensifentrine
  • Ensifentrine ( RPL554 )
  • EnsifentrineQ: What is Ensifentrine Q: What is the CAS Number of Ensifentrine
  • Ensifentrina
  • Ensifentrinum
  • RPL 554,RPL554,inhaled,Inhibitor,RPL-554,Ensifentrine,bronchoprotective,inhibit,COPD,PDE4,anti-inflammatory,PDE3,Phosphodiesterase (PDE)
  • Ensifentrine, 10 mM in DMSO
  • (E)-RPL-554
  • (E)-1-(2-(2-(Mesitylimino)-9,10-dimethoxy-4-oxo-6,7-dihydro-2H-pyrimido[6,1-a]isoquinolin-3(4H)-yl)ethyl)urea
  • (E)-1-(2-(2-(Mesitylimino)-9,10-dimethoxy-4-oxo-6,7-dihydro-2H-pyrimido[6,1-a]isoquinolin-3(4H)-yl)ethyl)urea , Ensifentrine
  • N-[2-[(2E)-6,7-dihydro-9,10-dimethoxy-4-oxo-2-[(2,4,6-trimethylphenyl)imino]-2H-pyrimido[6,1-a]isoquinolin-3(4H)-yl]ethyl]-
  • 1884461-72-6
  • 188461-72-6
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