ChemicalBook > CAS DataBase List > Carbamic acid, N-[(5S)-5-[[(2R,3S)-3-(formylhydroxyamino)-2-(2-methylpropyl)-1-oxohexyl]amino]-6-oxo-6-(2-thiazolylamino)hexyl]-, phenylmethyl ester

Carbamic acid, N-[(5S)-5-[[(2R,3S)-3-(formylhydroxyamino)-2-(2-methylpropyl)-1-oxohexyl]amino]-6-oxo-6-(2-thiazolylamino)hexyl]-, phenylmethyl ester

Product Name
Carbamic acid, N-[(5S)-5-[[(2R,3S)-3-(formylhydroxyamino)-2-(2-methylpropyl)-1-oxohexyl]amino]-6-oxo-6-(2-thiazolylamino)hexyl]-, phenylmethyl ester
CAS No.
866924-39-2
Chemical Name
Carbamic acid, N-[(5S)-5-[[(2R,3S)-3-(formylhydroxyamino)-2-(2-methylpropyl)-1-oxohexyl]amino]-6-oxo-6-(2-thiazolylamino)hexyl]-, phenylmethyl ester
Synonyms
GW280264X，Carbamic acid;GW280264X, 10 mM in DMSO;Benzyl ((S)-5-((2R,3S)-3-(N-hydroxyformamido)-2-isobutylhexanamido)-6-oxo-6-(thiazol-2-ylamino)hexyl)carbamate;benzyl N-[(5S)-5-[(2R,3S)-3-(N-hydroxyformamido)-2-(2-methylpropyl)hexanamido]-5-[(1,3-thiazol-2-yl)carbamoyl]pentyl]carbamate;Carbamic acid, N-[(5S)-5-[[(2R,3S)-3-(formylhydroxyamino)-2-(2-methylpropyl)-1-oxohexyl]amino]-6-oxo-6-(2-thiazolylamino)hexyl]-, phenylmethyl ester;GW-280264X,inhibit,GIC,Inhibitor,immunotherapy,metalloproteinases,Matrix metalloproteinases,ADAM10,TACE,immunogenicity,glioblastoma,Mixed,MMP,GW280264X,ADAM17,stem
CBNumber
CB78202465
Molecular Formula
C28H41N5O6S
Formula Weight
575.72
MOL File
866924-39-2.mol
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Carbamic acid, N-[(5S)-5-[[(2R,3S)-3-(formylhydroxyamino)-2-(2-methylpropyl)-1-oxohexyl]amino]-6-oxo-6-(2-thiazolylamino)hexyl]-, phenylmethyl ester Property

Density 
1.229±0.06 g/cm3(Predicted)
storage temp. 
-20°C
solubility 
DMSO: soluble
form 
A crystalline solid
pka
8.27±0.50(Predicted)
color 
White to off-white
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
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N-Bromosuccinimide Price

TRC
Product number
G931545
Product name
GW280264X
Packaging
2.5mg
Price
$550
Updated
2021/12/16
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Carbamic acid, N-[(5S)-5-[[(2R,3S)-3-(formylhydroxyamino)-2-(2-methylpropyl)-1-oxohexyl]amino]-6-oxo-6-(2-thiazolylamino)hexyl]-, phenylmethyl ester Chemical Properties,Usage,Production

Uses

GW 280264X is a inhibitor of the metalloproteinase ADAM17.

in vivo

Pharmacological inhibition of ADAM10 and ADAM17 improves functional recovery after spinal cord injury (SCI)[3].

Animal Model:C57BL/6 mice[3]
Dosage:100 ?μg/kg
Administration:I.p. injected; every day for one week starting 4?h post-surgery
Result:Showed significantly improved functional recovery compared to the control group.

IC 50

ADAM17: 8 nM (IC50); ADAM10: 11.5 nM (IC50)

storage

Store at -20°C

Carbamic acid, N-[(5S)-5-[[(2R,3S)-3-(formylhydroxyamino)-2-(2-methylpropyl)-1-oxohexyl]amino]-6-oxo-6-(2-thiazolylamino)hexyl]-, phenylmethyl ester Preparation Products And Raw materials

Raw materials

Preparation Products

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Carbamic acid, N-[(5S)-5-[[(2R,3S)-3-(formylhydroxyamino)-2-(2-methylpropyl)-1-oxohexyl]amino]-6-oxo-6-(2-thiazolylamino)hexyl]-, phenylmethyl ester Suppliers

China 44 United States 5 Global 49
ShangHai Caerulum Pharma Discovery Co., Ltd.
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Shanghai Lollane Biological Technology Co.,Ltd.
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Career Henan Chemica Co
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866924-39-2, Carbamic acid, N-[(5S)-5-[[(2R,3S)-3-(formylhydroxyamino)-2-(2-methylpropyl)-1-oxohexyl]amino]-6-oxo-6-(2-thiazolylamino)hexyl]-, phenylmethyl esterRelated Search:

GW 4064 GW843682, 5-(5,6-Dimethoxy-1H-benzimidazol-1-yl)-3-{[2-(trifluoromethyl)-benzyl]oxy}thiophene-2-carboxamide GW-6604 GW 627368X GW 6471 GW806742X

  • Carbamic acid, N-[(5S)-5-[[(2R,3S)-3-(formylhydroxyamino)-2-(2-methylpropyl)-1-oxohexyl]amino]-6-oxo-6-(2-thiazolylamino)hexyl]-, phenylmethyl ester
  • Benzyl ((S)-5-((2R,3S)-3-(N-hydroxyformamido)-2-isobutylhexanamido)-6-oxo-6-(thiazol-2-ylamino)hexyl)carbamate
  • GW280264X，Carbamic acid
  • GW-280264X,inhibit,GIC,Inhibitor,immunotherapy,metalloproteinases,Matrix metalloproteinases,ADAM10,TACE,immunogenicity,glioblastoma,Mixed,MMP,GW280264X,ADAM17,stem
  • benzyl N-[(5S)-5-[(2R,3S)-3-(N-hydroxyformamido)-2-(2-methylpropyl)hexanamido]-5-[(1,3-thiazol-2-yl)carbamoyl]pentyl]carbamate
  • GW280264X, 10 mM in DMSO
  • 866924-39-2