Dot1L-IN-4

Product Name: Dot1L-IN-4
CAS No.: 2565705-02-2
Chemical Name: Dot1L-IN-4
Synonyms: Dot1L- IN-4;QQN05022(Dot1L-IN-4);H3K79,Histone Methyltransferase,histone,methyltransferase,lysine,DOT1L,Dot1L IN 4,Inhibitor,Dot-1L-IN-4,Dot1LIN4,inhibit;N1-[(3-Chloro-pyridin-2-yl)-(2,2-difluoro-benzo[1,3]dioxol-4-yl)-methyl]-4-methanesulfonyl-N2-(4-methoxy-6-piperazin-1-yl-[1,3,5]triazin-2-yl)-benzene-1,2-diamine;1,2-Benzenediamine, N1-[(S)-(3-chloro-2-pyridinyl)(2,2-difluoro-1,3-benzodioxol-4-yl)methyl]-N2-[4-methoxy-6-(1-piperazinyl)-1,3,5-triazin-2-yl]-4-(methylsulfonyl)-;N1-[(S)-(3-chloropyridin-2-yl)(2,2-difluoro-2H-1,3-benzodioxol-4-yl)methyl]-4-methanesulfonyl-N2-[4-methoxy-6-(piperazin-1-yl)-1,3,5-triazin-2-yl]benzene-1,2-diamine
CBNumber: CB78364259
Molecular Formula: C28H27ClF2N8O5S
Formula Weight: 661.08
MOL File: 2565705-02-2.mol

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Dot1L-IN-4 Property

Boiling point:: 792.1±70.0 °C(Predicted)
Density: 1.58±0.1 g/cm3(Predicted)
storage temp.: Store at -20°C
solubility: DMSO : 250 mg/mL (378.17 mM; Need ultrasonic)
form: A solid
pka: 8.67±0.10(Predicted)
color: White to light yellow

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Hazard and Precautionary Statements (GHS)

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N-Bromosuccinimide Price

ChemScene

Product number: CS-0109501
Product name: Dot1L-IN-4
Purity: 99.60%
Packaging: 5mg
Price: $580
Updated: 2021/12/16

ChemScene

Product number: CS-0109501
Product name: Dot1L-IN-4
Purity: 99.60%
Packaging: 10mg
Price: $980
Updated: 2021/12/16

ChemScene

Product number: CS-0109501
Product name: Dot1L-IN-4
Purity: 99.60%
Packaging: 25mg
Price: $1900
Updated: 2021/12/16

ChemScene

Product number: CS-0109501
Product name: Dot1L-IN-4
Purity: 99.60%
Packaging: 50mg
Price: $3200
Updated: 2021/12/16

ChemScene

Product number: CS-0109501
Product name: Dot1L-IN-4
Purity: 99.60%
Packaging: 100mg
Price: $5000
Updated: 2021/12/16

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Dot1L-IN-4 Chemical Properties,Usage,Production

Biological Activity

Dot1L-IN-4 is a potent disruptor of telomeric silencing 1-like protein (DOT1L) inhibitor with an IC50 SPA DOT1L of 0.11 nM[1]. Dot1L-IN-4 (Compound 10) is tested in cellular assays to assess the ability to inhibit the dimethylation of H3K79 in HeLa cells (ED50 H3K79me2 Elisa=1.7 nM) and HOXA9 gene expression in Molm-13 cells (ED50 HOXA9 RGA=33 nM). Dot1L-IN-4 also inhibits mixed lineage leukemia (MLL) with an IC50 of 99 μM[1]. Dot1L-IN-4 (Compound 10; 300 mg/kg; p.o.; qd) is not tolerated at such a high dose by tumor xenograft bearing mice, and at a 6-fold reduced dose, the tumor growth as well as the HOXA9 reporter gene mRNA are reduced only by less than half as compared to control animals[1].

References

[1]. Frédéric Stauffer, et al. New Potent DOT1L Inhibitors for in Vivo Evaluation in Mouse. ACS Med. Chem. Lett. 2019, 10, 12, 1655-1660.

Dot1L-IN-4 Preparation Products And Raw materials

Raw materials

Preparation Products

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Dot1L-IN-4 Suppliers

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2565705-02-2, Dot1L-IN-4Related Search:

1,2-Benzenediamine, N1-[(S)-(3-chloro-2-pyridinyl)(2,2-difluoro-1,3-benzodioxol-4-yl)methyl]-N2-[4-methoxy-6-(1-piperazinyl)-1,3,5-triazin-2-yl]-4-(methylsulfonyl)-

Dot1L- IN-4

QQN05022(Dot1L-IN-4)

N1-[(3-Chloro-pyridin-2-yl)-(2,2-difluoro-benzo[1,3]dioxol-4-yl)-methyl]-4-methanesulfonyl-N2-(4-methoxy-6-piperazin-1-yl-[1,3,5]triazin-2-yl)-benzene-1,2-diamine

H3K79,Histone Methyltransferase,histone,methyltransferase,lysine,DOT1L,Dot1L IN 4,Inhibitor,Dot-1L-IN-4,Dot1LIN4,inhibit

N1-[(S)-(3-chloropyridin-2-yl)(2,2-difluoro-2H-1,3-benzodioxol-4-yl)methyl]-4-methanesulfonyl-N2-[4-methoxy-6-(piperazin-1-yl)-1,3,5-triazin-2-yl]benzene-1,2-diamine

2565705-02-2

C28H27ClF2N8O5S