5,6-DIMETHYL-2-OXO-1,2-DIHYDRO-PYRIDINE-3-CARBONITRILE
- Product Name
- 5,6-DIMETHYL-2-OXO-1,2-DIHYDRO-PYRIDINE-3-CARBONITRILE
- CAS No.
- 72716-80-4
- Chemical Name
- 5,6-DIMETHYL-2-OXO-1,2-DIHYDRO-PYRIDINE-3-CARBONITRILE
- Synonyms
- 3-Pyridinecarbonitrile, 1,2-dihydro-5,6-diMethyl-2-oxo-;104166;3-Cyano-5,6-diMethylpyrid-2-one;3-Cyano-5,6-diMethylpyridin-2-ol;2-Hydroxy-5,6-dimethylnicotinonitrile;2-Hydroxy-3-cyano-5,6-diMethylpyridine;2-Hydroxy-5,6-dimethyl-3-pyridinecarbonitrile;2-HYDROXY-5,6-DIMETHYLPYRIDINE-3-CARBONITRILE;1,2-dihydro-5,6-diMethyl-2-oxo-3-Pyridinecarbonitrile;1,2-dihydro-5,6-dimethyl-2-oxopyridine-3-carbonitrile
- CBNumber
- CB7837201
- Molecular Formula
- C8H8N2O
- Formula Weight
- 148.16
- MOL File
- 72716-80-4.mol
5,6-DIMETHYL-2-OXO-1,2-DIHYDRO-PYRIDINE-3-CARBONITRILE Property
- Melting point:
- 270 °C
- Boiling point:
- 335.6±35.0 °C(Predicted)
- Density
- 1.16±0.1 g/cm3(Predicted)
- storage temp.
- Inert atmosphere,Room Temperature
- solubility
- Acetic Acid, DMSO
- pka
- 9.44±0.10(Predicted)
- Appearance
- White to yellow Solid
Safety
- HS Code
- 2933399990
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H302Harmful if swallowed
H315Causes skin irritation
H319Causes serious eye irritation
H332Harmful if inhaled
H335May cause respiratory irritation
- Precautionary statements
-
P280Wear protective gloves/protective clothing/eye protection/face protection.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
P310Immediately call a POISON CENTER or doctor/physician.
N-Bromosuccinimide Price
- Product number
- H825240
- Product name
- 2-Hydroxy-5,6-dimethyl-3-pyridinecarbonitrile
- Packaging
- 2g
- Price
- $245
- Updated
- 2021/12/16
- Product number
- 279341
- Product name
- 2-Hydroxy-5,6-dimethyl-3-pyridinecarbonitrile
- Packaging
- 1g
- Price
- $460
- Updated
- 2021/12/16
- Product number
- CHM0299000
- Product name
- 5,6-DIMETHYL-2-OXO-1,2-DIHYDRO-PYRIDINE-3-CARBONITRILE
- Purity
- 95.00%
- Packaging
- 5MG
- Price
- $500.94
- Updated
- 2021/12/16
- Product number
- 069698
- Product name
- 5,6-Dimethyl-2-oxo-1,2-dihydropyridine-3-carbonitrile
- Purity
- 95%
- Packaging
- 500mg
- Price
- $341
- Updated
- 2021/12/16
- Product number
- CS-0038492
- Product name
- 5,6-Dimethyl-2-oxo-1,2-dihydropyridine-3-carbonitrile
- Packaging
- 5g
- Price
- $345
- Updated
- 2021/12/16
5,6-DIMETHYL-2-OXO-1,2-DIHYDRO-PYRIDINE-3-CARBONITRILE Chemical Properties,Usage,Production
Uses
An intermediate in the preparation of HIV-1 specific reverse transcriptase inhibitors, antiallergic agents, and Omeprazole metabolites.
Synthesis Reference(s)
Journal of Heterocyclic Chemistry, 24, p. 351, 1987 DOI: 10.1002/jhet.5570240211
Synthesis
143193-92-4
107-91-5
72716-80-4
The general procedure for the synthesis of 2-hydroxy-3-cyano-5,6-dimethylpyridine from the compound (CAS:143193-92-4) and cyanoacetamide was as follows: sodium (E/Z)-2-methyl-3-oxo-1-en-1-ol (77.6 g, 0.64 mol) was added to 480 mL of water, followed by the addition of cyanoacetamide (49.0 g, 0.70 mol). To the mixture was added a piperidine-acetic acid solution prepared from acetic acid (9.16 g, 8.75 mL, 0.15 mol), 21.2 mL of water and pyridine (13.0 g, 15.1 mL, 0.15 mol). The mixture was heated at reflux for 4 hours and then stirred at room temperature for 16 hours. Upon completion of the reaction, acetic acid (75.5 g, 72 mL, 1.26 mol) was added to the reaction mixture, prompting the precipitation of a pale yellow solid. The precipitate was collected by diafiltration, washed with water and dried under reduced pressure at 55 °C for 2 hours. A final 66.4 g (70% of theoretical yield) of light yellow solid product was obtained.
References
[1] Patent: CN105530814, 2016, A. Location in patent: Paragraph 0328; 0329; 0330
[2] Journal of Heterocyclic Chemistry, 1987, vol. 24, p. 351 - 355
5,6-DIMETHYL-2-OXO-1,2-DIHYDRO-PYRIDINE-3-CARBONITRILE Preparation Products And Raw materials
Raw materials
Preparation Products
5,6-DIMETHYL-2-OXO-1,2-DIHYDRO-PYRIDINE-3-CARBONITRILE Suppliers
- Tel
- --
- Fax
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- y.barysheva@ukrorgsynth.com
- Country
- Ukraine
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View Lastest Price from 5,6-DIMETHYL-2-OXO-1,2-DIHYDRO-PYRIDINE-3-CARBONITRILE manufacturers
- Product
- 2-Hydroxy-5,6-dimethyl-3-pyridinecarbonitrile 72716-80-4
- Price
- US $1.60-9.60/kg
- Min. Order
- 1kg
- Purity
- 99%
- Supply Ability
- 100kg
- Release date
- 2025-06-20
- Product
- 5,6-DIMETHYL-2-OXO-1,2-DIHYDRO-PYRIDINE-3-CARBONITRILE 72716-80-4
- Price
- US $1.10/g
- Min. Order
- 1g
- Purity
- 99.0% min
- Supply Ability
- 100 tons min
- Release date
- 2021-05-25
- Product
- 5,6-DIMETHYL-2-OXO-1,2-DIHYDRO-PYRIDINE-3-CARBONITRILE 72716-80-4
- Price
- US $9.80/KG
- Min. Order
- 1g
- Purity
- ≥99%
- Supply Ability
- 100kg
- Release date
- 2019-12-24