5-IODO-3-(TRIFLUOROMETHYL)-2(1H)-PYRIDINONE

Product Name: 5-IODO-3-(TRIFLUOROMETHYL)-2(1H)-PYRIDINONE
CAS No.: 887707-23-5
Chemical Name: 5-IODO-3-(TRIFLUOROMETHYL)-2(1H)-PYRIDINONE
Synonyms: 5-iodo-3-(trifluoromethyl)pyridin-2-ol;3-(trifluoromethyl)-5-iodopyridin-2-ol;5-Iodo-3-trifluoroMethyl-1H-pyridin-2-one;5-Iodo-3-(trifluoromethyl)-2(1H)-yridinone;5-IODO-3-(TRIFLUOROMETHYL)-2(1H)-PYRIDINONE;5-iodo-3-(trifluoroMethyl)pyridin-2(1H)-one;5-Iodo-2-hydroxy-3-(trifluoroMethyl)pyridine;2-Hydroxy-5-Iodo-3-(trifluoromethyl)pyridine;2(1H)-Pyridinone, 5-iodo-3-(trifluoromethyl)-;2-Hydroxy-5-iodo-3-(trifluoromethyl)pyridine 95%
CBNumber: CB42449645
Molecular Formula: C6H3F3INO
Formula Weight: 288.99
MOL File: 887707-23-5.mol

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5-IODO-3-(TRIFLUOROMETHYL)-2(1H)-PYRIDINONE Property

Melting point:: 145-147℃
Boiling point:: 249℃
Density: 2.11
Flash point:: 105℃
storage temp.: Keep in dark place,Inert atmosphere,Room temperature
form: wooly crystalline powder
pka: 7.80±0.10(Predicted)
color: Light gold/orange

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Safety

HazardClass: IRRITANT
HS Code: 2933399990

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H302Harmful if swallowed

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

Apolloscientific

Product number: PC56189
Product name: 2-Hydroxy-5-iodo-3-(trifluoromethyl)pyridine
Purity: 95%
Packaging: 1g
Price: $28
Updated: 2021/12/16

Apolloscientific

Product number: PC56189
Product name: 2-Hydroxy-5-iodo-3-(trifluoromethyl)pyridine
Purity: 95%
Packaging: 5g
Price: $95
Updated: 2021/12/16

SynQuest Laboratories

Product number: 4H01-K-00
Product name: 2-Hydroxy-5-iodo-3-(trifluoromethyl)pyridine
Packaging: 1g
Price: $144
Updated: 2021/12/16

AK Scientific

Product number: W9180
Product name: 5-Iodo-2-hydroxy-3-(trifluoromethyl)pyridine
Packaging: 5g
Price: $386
Updated: 2021/12/16

SynQuest Laboratories

Product number: 4H01-K-00
Product name: 2-Hydroxy-5-iodo-3-(trifluoromethyl)pyridine
Packaging: 5G
Price: $413
Updated: 2021/12/16

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5-IODO-3-(TRIFLUOROMETHYL)-2(1H)-PYRIDINONE Chemical Properties,Usage,Production

Synthesis

22245-83-6

887707-23-5

General procedure for the synthesis of 2-hydroxy-5-iodo-3-(trifluoromethyl)pyridine from 2-hydroxy-3-trifluoromethylpyridine: 1. 3-Trifluoromethyl-2-pyridinol (25 g, 153.3 mmol) was dissolved in a mixed solvent of anhydrous acetonitrile (150 mL) and N,N-dimethylformamide (150 mL). 2. N-iodosuccinimide (34.5 g, 153 mmol) was added to the above solution. 3. The reaction mixture was stirred at 80 °C for 2 hours and subsequently cooled to room temperature. 4. 1 M aqueous sodium bicarbonate (150 mL) was added to the cooled reaction mixture and stirred for 5 minutes. 5. The mixed solvents were evaporated to dryness, an appropriate amount of water was added and the aqueous phase was extracted twice with dichloromethane. 6. The organic phases were combined and evaporated, and the resulting crude product was recrystallized in water to give 36.2 g (81% yield) of a white powdery target product, 2-hydroxy-5-iodo-3-(trifluoromethyl)pyridine. Product characterization data: 1H NMR (500 MHz, CDCl3) δ 7.85 (d, J = 2.3 Hz, 1H), 7.98 (d, J = 2.3 Hz, 1H), 13.41 (br s, 1H). 13C NMR (250 MHz, CDCl3) δ 63.0, 121.4 (q, JC-F = 272.3 Hz), 122.2 (q, JC-F = 31.6 Hz), 144.4, 148.1 (q, JC-F = 5.0 Hz), 160.1.

References

[1] Organic Process Research and Development, 2013, vol. 17, # 12, p. 1561 - 1567
[2] Patent: WO2008/119015, 2008, A2. Location in patent: Page/Page column 48
[3] Patent: JP2016/11315, 2016, A. Location in patent: Paragraph 0084
[4] Patent: US9388159, 2016, B2. Location in patent: Page/Page column 19; 20; 21
[5] Patent: WO2015/100613, 2015, A1. Location in patent: Page/Page column 17

5-IODO-3-(TRIFLUOROMETHYL)-2(1H)-PYRIDINONE Preparation Products And Raw materials

Raw materials

Preparation Products

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5-IODO-3-(TRIFLUOROMETHYL)-2(1H)-PYRIDINONE Suppliers

China 94 India 2 United Kingdom 1 United States 9 Global 106

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View Lastest Price from 5-IODO-3-(TRIFLUOROMETHYL)-2(1H)-PYRIDINONE manufacturers

Dideu Industries Group Limited

Product: 5-IODO-3-(TRIFLUOROMETHYL)-2(1H)-PYRIDINONE 887707-23-5
Price: US $1.10/g
Min. Order: 1g
Purity: 99.00%
Supply Ability: 100 Tons Min
Release date: 2021-09-26

Career Henan Chemical Co

Product: 5-IODO-3-(TRIFLUOROMETHYL)-2(1H)-PYRIDINONE 887707-23-5
Price: US $1.00/g
Min. Order: 1g
Purity: 99%
Supply Ability: 1000KGS
Release date: 2019-12-19

887707-23-5, 5-IODO-3-(TRIFLUOROMETHYL)-2(1H)-PYRIDINONERelated Search:

2-hydroxy-5-iodonicotinic acid 5-Chloro-2-hydroxypyrazine 5-FLUORO-2-HYDROXY-3-NITROPYRIDINE Ethyl 2-hydroxy-5-nitronicotinate 5-bromo-6-hydroxypyridine-3-carbonitrile 2-(4-BROMOPHENYL)PROPAN-2-OL 5-AMINOMETHYL-1H-PYRIDIN-2-ONE 2-HYDROXY-3-PHENYLPYRIDINE 5-BROMO-3-CHLORO-2-HYDROXYPYRIDINE 3-BroMo-6-chloropyridin-2-ol 2-HYDROXY-5-METHYLPYRAZINE 2-HYDROXY-5-NITRO-3-(TRIFLUOROMETHYL)PYRIDINE 6-CHLORO-1,3-DIHYDRO-2H-IMIDAZO[4,5-B]PYRIDIN-2-ONE 2-HYDROXY-5-IODO-BENZONITRILE 3-Cyano-2-hydroxy-5-iodopyridine 2-Hydroxy-4-methyl-6-(trifluoromethyl)-pyridine 5,6-DIMETHYL-2-OXO-1,2-DIHYDRO-PYRIDINE-3-CARBONITRILE Methyl 2-hydroxy-6-methylisonicotinate

5-IODO-3-(TRIFLUOROMETHYL)-2(1H)-PYRIDINONE

5-iodo-3-(trifluoromethyl)pyridin-2-ol

2-Hydroxy-5-Iodo-3-(trifluoromethyl)pyridine

5-Iodo-2-hydroxy-3-(trifluoroMethyl)pyridine

5-iodo-3-(trifluoroMethyl)pyridin-2(1H)-one

5-Iodo-3-trifluoroMethyl-1H-pyridin-2-one

3-(trifluoromethyl)-5-iodopyridin-2-ol

2-Hydroxy-5-iodo-3-(trifluoromethyl)pyridine 95%

2(1H)-Pyridinone, 5-iodo-3-(trifluoromethyl)-

5-IODO-3-(TRIFLUOROMETHYL)-2(1H)-PYRIDINONE ISO 9001：2015 REACH

5-Iodo-3-(trifluoromethyl)-2(1H)-yridinone

887707-23-5

C6H3F3INO

Fluorine series