2-hydroxy-5-iodonicotinic acid
- Product Name
- 2-hydroxy-5-iodonicotinic acid
- CAS No.
- 390360-97-1
- Chemical Name
- 2-hydroxy-5-iodonicotinic acid
- Synonyms
- 2-hydroxy-5-iodonicotinic acid;2-Hydroxy-5-iodopyridine-3-carboxylic acid;5-iodo-2-oxo-1H-pyridine-3-carboxylic acid;3-Pyridinecarboxylic acid, 1,2-dihydro-5-iodo-2-oxo-
- CBNumber
- CB81528462
- Molecular Formula
- C6H4INO3
- Formula Weight
- 265.01
- MOL File
- 390360-97-1.mol
2-hydroxy-5-iodonicotinic acid Property
- Melting point:
- 264-266°
- storage temp.
- under inert gas (nitrogen or Argon) at 2–8 °C
- form
- solid
- color
- Pale yellow
- InChI
- InChI=1S/C6H4INO3/c7-3-1-4(6(10)11)5(9)8-2-3/h1-2H,(H,8,9)(H,10,11)
- InChIKey
- WIUHBFOGCTVLEH-UHFFFAOYSA-N
- SMILES
- C1(=O)NC=C(I)C=C1C(O)=O
Safety
- HazardClass
- IRRITANT
- HS Code
- 2933399990
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H315Causes skin irritation
H319Causes serious eye irritation
H335May cause respiratory irritation
- Precautionary statements
-
P280Wear protective gloves/protective clothing/eye protection/face protection.
P301+P312IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.
N-Bromosuccinimide Price
- Product number
- 046178
- Product name
- 2-Hydroxy-5-iodonicotinic acid
- Purity
- >95%
- Packaging
- 500mg
- Price
- $72
- Updated
- 2021/12/16
- Product number
- 046178
- Product name
- 2-Hydroxy-5-iodonicotinic acid
- Purity
- >95%
- Packaging
- 1g
- Price
- $111
- Updated
- 2021/12/16
- Product number
- 5072AB
- Product name
- 2-Hydroxy-5-iodonicotinicacid
- Packaging
- 5g
- Price
- $300
- Updated
- 2021/12/16
- Product number
- 046178
- Product name
- 2-Hydroxy-5-iodonicotinic acid
- Purity
- >95%
- Packaging
- 5g
- Price
- $300
- Updated
- 2021/12/16
- Product number
- AK-69910
- Product name
- 2-Hydroxy-5-iodonicotinicacid
- Purity
- 95+%
- Packaging
- 5g
- Price
- $160
- Updated
- 2021/12/16
2-hydroxy-5-iodonicotinic acid Chemical Properties,Usage,Production
Synthesis
609-71-2
390360-97-1
General procedure for the synthesis of 2-hydroxy-5-iodopyridine-3-carboxylic acid from 2-hydroxynicotinic acid: a mixture of 2-hydroxynicotinic acid (24 g, 173 mmol) and N-iodosuccinimide (50.5 g, 224 mmol) in N,N-dimethylformamide (DMF, 300 mL) was reacted for 1 h at room temperature, protected from light, and then stirred for 20 h at 50 °C. . Upon completion of the reaction, about 250 mL of DMF was removed by distillation under reduced pressure and water (400 mL) was added to the residue. The mixture was stirred at room temperature for 1 h, followed by continued stirring at 0 °C for 1 h. The precipitated solid was collected by filtration. The resulting solid was suspended in methanol (MeOH, 200 mL) and stirred at room temperature for 2 h. The mixture was filtered again, washed with methanol (40 mL), and finally dried under vacuum to afford the target compound 2-hydroxy-5-iodopyridine-3-carboxylic acid (19, light yellow solid, 38.4 g, 76% yield). The structure of the product was confirmed by 1H NMR (400 MHz, CDCl3) δ= 8.41 (d, J = 2.4 Hz, 1H), 8.23 (d, J = 2.4 Hz, 1H) and mass spectra (ESI+) m/z 265.9 ([M + H]+).
References
[1] Bioorganic and Medicinal Chemistry, 2015, vol. 23, # 15, p. 4792 - 4803
[2] Journal of Medicinal Chemistry, 1997, vol. 40, # 17, p. 2674 - 2687
2-hydroxy-5-iodonicotinic acid Preparation Products And Raw materials
Raw materials
Preparation Products
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