5-FLUORO-2-HYDROXY-3-NITROPYRIDINE
- Product Name
- 5-FLUORO-2-HYDROXY-3-NITROPYRIDINE
- CAS No.
- 136888-20-5
- Chemical Name
- 5-FLUORO-2-HYDROXY-3-NITROPYRIDINE
- Synonyms
- 5-fluoro-2-hydroxy-3-nitrop;5-fluoro-3-nitropyridin-2-ol;5-Fluoro-3-nitro-2-pyridinol;uoro-2-hydroxy-3-nitropyridine;5-bromo-2-methoxynicotinaldehyde;5-Fluoro-3-nitropyridin-2(1H)-one;5-Fluoro-2-Hydroxy-3-Nitropyridin;5-fluoro-3-nitro-1H-pyridin-2-one;5-Fluoro-3-nitro-2(1H)-pyridinone;2-hydroxy-5-fluoro-3-nitropyridine
- CBNumber
- CB7293797
- Molecular Formula
- C5H3FN2O3
- Formula Weight
- 158.09
- MOL File
- 136888-20-5.mol
5-FLUORO-2-HYDROXY-3-NITROPYRIDINE Property
- Boiling point:
- 249.1±40.0 °C(Predicted)
- Density
- 1.55±0.1 g/cm3(Predicted)
- storage temp.
- Inert atmosphere,Room Temperature
- form
- Solid
- pka
- 6.43±0.10(Predicted)
- Appearance
- Light yellow to yellow Solid
- Water Solubility
- Slightly soluble in water.
- CAS DataBase Reference
- 136888-20-5(CAS DataBase Reference)
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H315Causes skin irritation
H319Causes serious eye irritation
H335May cause respiratory irritation
- Precautionary statements
-
P261Avoid breathing dust/fume/gas/mist/vapours/spray.
P304+P340IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
P405Store locked up.
N-Bromosuccinimide Price
- Product number
- F597698
- Product name
- 5-Fluoro-3-nitropyridin-2-ol
- Packaging
- 100mg
- Price
- $45
- Updated
- 2021/12/16
- Product number
- F597698
- Product name
- 5-Fluoro-3-nitropyridin-2-ol
- Packaging
- 500mg
- Price
- $65
- Updated
- 2021/12/16
- Product number
- F597698
- Product name
- 5-Fluoro-3-nitropyridin-2-ol
- Packaging
- 1g
- Price
- $75
- Updated
- 2021/12/16
- Product number
- J50758
- Product name
- 5-Fluoro-2-hydroxy-3-nitropyridine
- Packaging
- 10g
- Price
- $93
- Updated
- 2021/12/16
- Product number
- 073630
- Product name
- 5-Fluoro-2-hydroxy-3-nitropyridine
- Purity
- 95+%
- Packaging
- 5g
- Price
- $160
- Updated
- 2021/12/16
5-FLUORO-2-HYDROXY-3-NITROPYRIDINE Chemical Properties,Usage,Production
Chemical Properties
Yellow to light yellow liquid
Uses
It is used as a pharmaceutical intermediate.
Synthesis
51173-05-8
136888-20-5
a) Mix 2-hydroxy-5-fluoropyridine (1.20 g, 10.6 mmol) with concentrated sulfuric acid (2.7 mL), cool in an ice bath and stir. A mixture consisting of concentrated sulfuric acid (1 mL) and fuming nitric acid (1 mL) was slowly added dropwise. After the dropwise addition was completed, the reaction mixture was gradually warmed to room temperature and subsequently heated to 85°C for 2 hours. Upon completion of the reaction, the mixture was cooled and poured into ice water. The precipitate was collected by filtration and dried to give 2-hydroxy-3-nitro-5-fluoropyridine (0.72 g, 43% yield) as a yellow solid.LRMS (m/z): 157 (M-1)+.1H NMR (300 MHz, DMSO-d6) δ: 8.28 (s, 1H), 8.67 (s, 1H).
References
[1] Patent: EP2527344, 2012, A1. Location in patent: Page/Page column 22
[2] Patent: WO2012/160030, 2012, A1. Location in patent: Page/Page column 66
[3] Patent: WO2006/114706, 2006, A1. Location in patent: Page/Page column 45
[4] Journal of Heterocyclic Chemistry, 1996, vol. 33, # 2, p. 287 - 293
[5] Patent: US2004/110785, 2004, A1. Location in patent: Page 211
5-FLUORO-2-HYDROXY-3-NITROPYRIDINE Preparation Products And Raw materials
Raw materials
Preparation Products
5-FLUORO-2-HYDROXY-3-NITROPYRIDINE Suppliers
- Tel
- 18210857532; 18210857532
- Fax
- 86-10-82849933
- jkinfo@jkchemical.com
- Country
- China
- ProdList
- 96815
- Advantage
- 76
- Tel
- 4006356688 18621169109
- Fax
- 86-21-61259102
- market03@meryer.com
- Country
- China
- ProdList
- 40228
- Advantage
- 62
- Tel
- 400-021-7337 2355568890
- Fax
- 0086-21-50182339
- sales@demochem.com
- Country
- China
- ProdList
- 2572
- Advantage
- 57
- Tel
- +86 (0) 571 85 58 67 18
- Fax
- 0086-571-85864795
- Country
- China
- ProdList
- 18207
- Advantage
- 66
- Tel
- 001-857-928-2050 or 1-888-588-9418
- Fax
- 001-617-206-9595
- sales@chemreagents.com
- Country
- United States
- ProdList
- 10186
- Advantage
- 62
- Tel
- 400-6009262 16621234537
- Fax
- 021-64823266
- chenyj@titansci.com
- Country
- China
- ProdList
- 14101
- Advantage
- 59
- Tel
- 025-83697070
- Fax
- +86-25-83453306
- info@chemlin.com.cn
- Country
- China
- ProdList
- 15883
- Advantage
- 64
- Tel
- 021-54306202 13764082696
- info@hanhongsci.com
- Country
- China
- ProdList
- 42934
- Advantage
- 64
- Tel
- 021-50135380
- shchemsky@sina.com
- Country
- China
- ProdList
- 32321
- Advantage
- 50
- Tel
- 025-52161033 15312098939
- Fax
- 025-83254025
- sales@njdrschem.com
- Country
- China
- ProdList
- 583
- Advantage
- 64
View Lastest Price from 5-FLUORO-2-HYDROXY-3-NITROPYRIDINE manufacturers
- Product
- 5-FLUORO-2-HYDROXY-3-NITROPYRIDINE 136888-20-5
- Price
- US $0.00-0.00/KG
- Min. Order
- 1KG
- Purity
- 98.0%
- Supply Ability
- 10000KGS
- Release date
- 2025-06-04
- Product
- 5-FLUORO-2-HYDROXY-3-NITROPYRIDINE 136888-20-5
- Price
- US $5.00-0.10/KG
- Min. Order
- 1KG
- Purity
- 98%
- Supply Ability
- g-kg-tons, free sample is available
- Release date
- 2024-04-08
- Product
- 5-FLUORO-2-HYDROXY-3-NITROPYRIDINE 136888-20-5
- Price
- US $1.10/g
- Min. Order
- 1g
- Purity
- 99.00%
- Supply Ability
- 100 Tons Min
- Release date
- 2021-09-24