5-Fluoro-2-hydroxypyridine
- Product Name
- 5-Fluoro-2-hydroxypyridine
- CAS No.
- 51173-05-8
- Chemical Name
- 5-Fluoro-2-hydroxypyridine
- Synonyms
- 5-Fluoropyridin-2-ol;5-Fluorpyridin-2-ol;5-Fluoro-2-pyridinol;uoro-2-hydroxypyridine;5-fluoro-1H-pyridin-2-one;5-Fluoropyridin-2(1H)-one;3-Fluoro-6-hydroxypyridine;5-FLUORO-2-HYDROXYPYRIDINE;2-HYDROXY-5-FLUOROPYRIDINE;2(1H)-Pyridinone, 5-fluoro-
- CBNumber
- CB3203611
- Molecular Formula
- C5H4FNO
- Formula Weight
- 113.09
- MOL File
- 51173-05-8.mol
5-Fluoro-2-hydroxypyridine Property
- Melting point:
- 150-155°C
- Boiling point:
- 251.7±40.0 °C(Predicted)
- Density
- 1.26±0.1 g/cm3(Predicted)
- storage temp.
- Sealed in dry,Room Temperature
- pka
- 10.09±0.10(Predicted)
- form
- Crystalline Powder
- color
- White to off-white
- InChIKey
- KLULSYPVWLJZAO-UHFFFAOYSA-N
- CAS DataBase Reference
- 51173-05-8(CAS DataBase Reference)
Safety
- Hazard Codes
- Xn
- Risk Statements
- 22-37/38-41
- Safety Statements
- 26-39
- WGK Germany
- 3
- HazardClass
- IRRITANT
- HS Code
- 29333999
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Danger
- Hazard statements
-
H302Harmful if swallowed
H315Causes skin irritation
H318Causes serious eye damage
H335May cause respiratory irritation
- Precautionary statements
-
P280Wear protective gloves/protective clothing/eye protection/face protection.
P302+P352IF ON SKIN: wash with plenty of soap and water.
N-Bromosuccinimide Price
- Product number
- 753181
- Product name
- 5-Fluoro-2-hydroxypyridine
- Purity
- 97%
- Packaging
- 1g
- Price
- $46.5
- Updated
- 2023/06/20
- Product number
- F597988
- Product name
- 5-Fluoro-2-hydroxypyridine
- Packaging
- 50mg
- Price
- $60
- Updated
- 2021/12/16
- Product number
- 035690
- Product name
- 5-Fluoro-2-hydroxypyridine
- Purity
- 95+%
- Packaging
- 5g
- Price
- $59
- Updated
- 2021/12/16
- Product number
- BP-11523
- Product name
- 5-fluoropyridin-2-olhydrobromide
- Packaging
- 5G
- Price
- $185
- Updated
- 2021/12/16
- Product number
- 35270
- Product name
- 5-Fluoro-2-hydroxypyridine
- Purity
- 98%
- Packaging
- 10g
- Price
- $445
- Updated
- 2021/12/16
5-Fluoro-2-hydroxypyridine Chemical Properties,Usage,Production
Uses
5-Fluoro-2-hydroxypyridine is a halogenated compound used in the synthesis of 5-Fluoro-2-hydroxy-3-nitropyridine and 5-halogenated pyrimidine compounds.
Synthesis
5-Fluoro-2-hydroxypyridine is synthesised using 5-fluoro-2-methoxypyridine as a raw material by chemical reaction. The specific synthesis steps are as follows:
A total of 4.6 L of toluene solution containing 3-80 was placed in several sealed tubes and treated with 900 ml of 35percent HCl at 145° C. for 2 hr. LC/MS showed no starting material, only 4. The toluene solution was decanted and discarded. The aqueous phase was washed with EtOAc and concentrated down to remove volatiles to afford a brown solid containing the desired fluoro-hydroxypyridine 4-80. [1488] A total of 244 g of this solid was collected and taken to next step as is (it was not completely dry). [1489] Note: We have subsequently run this by decanting the toluene layer first prior to heating to reduce volumes. Same reaction was carried out using HBr (48percent in H2O) at 100° C. for 6 h with similar result to the literature procedure 49percent yield. [1490] Ref: J. Heterocyclic Chem., 10, 779, 1973 (for above Reactions, Including Analytical Data).
5-Fluoro-2-hydroxypyridine Preparation Products And Raw materials
Raw materials
Preparation Products
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View Lastest Price from 5-Fluoro-2-hydroxypyridine manufacturers
- Product
- 5-Fluoro-2-hydroxypyridine 51173-05-8
- Price
- US $10.00/KG
- Min. Order
- 1KG
- Purity
- 99%
- Supply Ability
- 10 mt
- Release date
- 2024-11-12
- Product
- 5-Fluoro-2-hydroxypyridine 51173-05-8
- Price
- US $5.00-0.10/KG
- Min. Order
- 1KG
- Purity
- 98%
- Supply Ability
- g-kg-tons, free sample is available
- Release date
- 2024-04-08
- Product
- 5-Fluoro-2-hydroxypyridine 51173-05-8
- Price
- US $0.00/kg
- Min. Order
- 1kg
- Purity
- 99%
- Supply Ability
- 1000tons
- Release date
- 2023-08-07