ChemicalBook > CAS DataBase List > 5-Fluoro-2-hydroxypyridine

5-Fluoro-2-hydroxypyridine

Product Name
5-Fluoro-2-hydroxypyridine
CAS No.
51173-05-8
Chemical Name
5-Fluoro-2-hydroxypyridine
Synonyms
5-Fluoropyridin-2-ol;5-Fluorpyridin-2-ol;5-Fluoro-2-pyridinol;uoro-2-hydroxypyridine;5-fluoro-1H-pyridin-2-one;5-Fluoropyridin-2(1H)-one;3-Fluoro-6-hydroxypyridine;5-FLUORO-2-HYDROXYPYRIDINE;2-HYDROXY-5-FLUOROPYRIDINE;2(1H)-Pyridinone, 5-fluoro-
CBNumber
CB3203611
Molecular Formula
C5H4FNO
Formula Weight
113.09
MOL File
51173-05-8.mol
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5-Fluoro-2-hydroxypyridine Property

Melting point:
150-155°C
Boiling point:
251.7±40.0 °C(Predicted)
Density 
1.26±0.1 g/cm3(Predicted)
storage temp. 
Sealed in dry,Room Temperature
pka
10.09±0.10(Predicted)
form 
Crystalline Powder
color 
White to off-white
InChIKey
KLULSYPVWLJZAO-UHFFFAOYSA-N
CAS DataBase Reference
51173-05-8(CAS DataBase Reference)
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Safety

Hazard Codes 
Xn
Risk Statements 
22-37/38-41
Safety Statements 
26-39
WGK Germany 
3
HazardClass 
IRRITANT
HS Code 
29333999
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Danger
Hazard statements

H302Harmful if swallowed

H315Causes skin irritation

H318Causes serious eye damage

H335May cause respiratory irritation

Precautionary statements

P280Wear protective gloves/protective clothing/eye protection/face protection.

P302+P352IF ON SKIN: wash with plenty of soap and water.

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N-Bromosuccinimide Price

Sigma-Aldrich
Product number
753181
Product name
5-Fluoro-2-hydroxypyridine
Purity
97%
Packaging
1g
Price
$46.5
Updated
2023/06/20
TRC
Product number
F597988
Product name
5-Fluoro-2-hydroxypyridine
Packaging
50mg
Price
$60
Updated
2021/12/16
Matrix Scientific
Product number
035690
Product name
5-Fluoro-2-hydroxypyridine
Purity
95+%
Packaging
5g
Price
$59
Updated
2021/12/16
BroadPharm
Product number
BP-11523
Product name
5-fluoropyridin-2-olhydrobromide
Packaging
5G
Price
$185
Updated
2021/12/16
Medical Isotopes, Inc.
Product number
35270
Product name
5-Fluoro-2-hydroxypyridine
Purity
98%
Packaging
10g
Price
$445
Updated
2021/12/16
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5-Fluoro-2-hydroxypyridine Chemical Properties,Usage,Production

Uses

5-Fluoro-2-hydroxypyridine is a halogenated compound used in the synthesis of 5-Fluoro-2-hydroxy-3-nitropyridine and 5-halogenated pyrimidine compounds.

Synthesis

5-Fluoro-2-hydroxypyridine is synthesised using 5-fluoro-2-methoxypyridine as a raw material by chemical reaction. The specific synthesis steps are as follows:
A total of 4.6 L of toluene solution containing 3-80 was placed in several sealed tubes and treated with 900 ml of 35percent HCl at 145° C. for 2 hr. LC/MS showed no starting material, only 4. The toluene solution was decanted and discarded. The aqueous phase was washed with EtOAc and concentrated down to remove volatiles to afford a brown solid containing the desired fluoro-hydroxypyridine 4-80. [1488] A total of 244 g of this solid was collected and taken to next step as is (it was not completely dry). [1489] Note: We have subsequently run this by decanting the toluene layer first prior to heating to reduce volumes. Same reaction was carried out using HBr (48percent in H2O) at 100° C. for 6 h with similar result to the literature procedure 49percent yield. [1490] Ref: J. Heterocyclic Chem., 10, 779, 1973 (for above Reactions, Including Analytical Data).

5-Fluoro-2-hydroxypyridine Preparation Products And Raw materials

Raw materials

Preparation Products

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View Lastest Price from 5-Fluoro-2-hydroxypyridine manufacturers

Hebei Weibang Biotechnology Co., Ltd
Product
5-Fluoro-2-hydroxypyridine 51173-05-8
Price
US $10.00/KG
Min. Order
1KG
Purity
99%
Supply Ability
10 mt
Release date
2024-11-12
Henan Fengda Chemical Co., Ltd
Product
5-Fluoro-2-hydroxypyridine 51173-05-8
Price
US $5.00-0.10/KG
Min. Order
1KG
Purity
98%
Supply Ability
g-kg-tons, free sample is available
Release date
2024-04-08
Hebei Mojin Biotechnology Co., Ltd
Product
5-Fluoro-2-hydroxypyridine 51173-05-8
Price
US $0.00/kg
Min. Order
1kg
Purity
99%
Supply Ability
1000tons
Release date
2023-08-07

51173-05-8, 5-Fluoro-2-hydroxypyridineRelated Search:

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  • 2-HYDROXY-5-FLUOROPYRIDINE
  • 5-FLUORO-2-HYDROXYPYRIDINE
  • 3-Fluoro-6-hydroxypyridine
  • 5-Fluoropyridin-2-ol
  • 5-Fluoropyridin-2(1H)-one
  • 5- fluoro-2-hydroxyl pyridine
  • 5-Fluoro-2-pyridinol
  • uoro-2-hydroxypyridine
  • 2(1H)-Pyridinone, 5-fluoro-
  • 5-Fluoro-2-hydroxypyridine ISO 9001：2015 REACH
  • 5-fluoro-1H-pyridin-2-one
  • 5-Fluorpyridin-2-ol
  • 51173-05-8
  • C5H4NOF
  • Fluorine series
  • blocks
  • FluoroCompounds
  • Pyridines
  • Pyridine
  • Fluorin-contained pyridine series