2-Fluoro-3-trifluoromethylpyridine
- Product Name
- 2-Fluoro-3-trifluoromethylpyridine
- CAS No.
- 65753-52-8
- Chemical Name
- 2-Fluoro-3-trifluoromethylpyridine
- Synonyms
- 2-FLUORO-TRIFLUOROMETHYLPYRIDINE;2-Floro-3-(trifluoroMethyl)pyridine;-Fluoro-3-(trifluoromethyl)pyridine;2-FLUORO-3-(TRIFLUOROMETHYL)PYRIDINE;2-FLUORO-3-(TRIFLUOROMETHOXY)PYRIDINE;Pyridine, 2-fluoro-3-(trifluoroMethyl)-;2-Fluoro-3-(trifluoromethyl)pyridine(FTF);alpha,alpha,alpha,2-Tetrafluoro-3-picoline;2-Fluoro-3-trifluoromethylpyridine Chemical Properties;2-Fluoro-3-trifluoromethylpyridine ISO 9001：2015 REACH
- CBNumber
- CB9317299
- Molecular Formula
- C6H3F4N
- Formula Weight
- 165.09
- MOL File
- 65753-52-8.mol
2-Fluoro-3-trifluoromethylpyridine Property
- Boiling point:
- 134-137 °C
- Density
- 1.371±0.06 g/cm3(Predicted)
- storage temp.
- under inert gas (nitrogen or Argon) at 2-8°C
- pka
- -2.86±0.10(Predicted)
- form
- liquid
- color
- Clear, colourless
- CAS DataBase Reference
- 65753-52-8(CAS DataBase Reference)
Safety
- Hazard Codes
- Xi,Xn,T
- Risk Statements
- 20/21/22-36/37/38-36-25
- Safety Statements
- 26-36/37/39-36-45
- HazardClass
- IRRITANT
- HS Code
- 2933399990
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H227Combustible liquid
H315Causes skin irritation
H319Causes serious eye irritation
H335May cause respiratory irritation
- Precautionary statements
-
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
N-Bromosuccinimide Price
- Product number
- F596260
- Product name
- 2-Fluoro-3-(trifluoromethyl)pyridine
- Packaging
- 100mg
- Price
- $50
- Updated
- 2021/12/16
- Product number
- F596260
- Product name
- 2-Fluoro-3-(trifluoromethyl)pyridine
- Packaging
- 5G
- Price
- $130
- Updated
- 2021/12/16
- Product number
- F596260
- Product name
- 2-Fluoro-3-(trifluoromethyl)pyridine
- Packaging
- 25g
- Price
- $525
- Updated
- 2021/12/16
- Product number
- 3H32-3-63
- Product name
- 2-Fluoro-3-(trifluoromethyl)pyridine
- Purity
- 98%
- Packaging
- 100g
- Price
- $632
- Updated
- 2021/12/16
- Product number
- 011123
- Product name
- 2-Fluoro-3-(trifluoromethyl)pyridine
- Purity
- 98%
- Packaging
- 25g
- Price
- $92
- Updated
- 2021/12/16
2-Fluoro-3-trifluoromethylpyridine Chemical Properties,Usage,Production
Chemical Properties
Colorless liquid
Uses
2-Fluoro-3-(trifluoromethyl)pyridine is a useful synthetic intermediate. It is used to prepare antihypertensive β-?adrenergic blocking agents. It is also used to synthesize HCV NS5B thumb pocket 2 allosteric inhibitors.
Synthesis
65753-47-1
65753-52-8
General procedure for the synthesis of 2-chloro-3-trifluoromethylpyridine from 2-chloro-3-trifluoromethylpyridine: In a desiccator, anhydrous tetramethylammonium fluoride (NMe4F, 18.6 mg, 0.2 mmol, 2 eq.) and 2-chloro-3-trifluoromethylpyridine (0.1 mmol, 1 eq.) were accurately weighed in a 4 mL sample vial, in which a micro stirring bar was placed in advance. Subsequently, N,N-dimethylformamide (DMF, 0.5 mL) was added as solvent. The sample bottle was removed from the desiccator and the reaction was stirred at room temperature for 24 hours unless otherwise stated. Upon completion of the reaction, the reaction mixture was cooled to room temperature and the internal standard (1,3,5-trifluorobenzene, 100 μL of 0.5 M toluene solution) was added. An appropriate amount of the reaction mixture was taken and analyzed by fluorine-19 nuclear magnetic resonance (59F NMR) spectroscopy and gas chromatography-mass spectrometry (GCMS).
References
[1] Chemistry Letters, 1993, # 3, p. 509 - 512
[2] Organic Letters, 2015, vol. 17, # 8, p. 1866 - 1869
[3] Journal of Organic Chemistry, 2015, vol. 80, # 24, p. 12137 - 12145
[4] Patent: WO2017/24167, 2017, A1. Location in patent: Page/Page column 29; 33
[5] Patent: CN108003093, 2018, A. Location in patent: Paragraph 0008; 0017; 0020; 0023
2-Fluoro-3-trifluoromethylpyridine Preparation Products And Raw materials
Raw materials
Preparation Products
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View Lastest Price from 2-Fluoro-3-trifluoromethylpyridine manufacturers
- Product
- 2-Fluoro-3-trifluoromethylpyridine Chemical Properties 65753-52-8
- Price
- US $10.00/KG
- Min. Order
- 1KG
- Purity
- 99%
- Supply Ability
- 20 Tons
- Release date
- 2021-10-15
- Product
- 2-Fluoro-3-trifluoromethylpyridine 65753-52-8
- Price
- US $1.10/g
- Min. Order
- 1g
- Purity
- 99.00%
- Supply Ability
- 100 Tons min
- Release date
- 2021-08-26
- Product
- 2-Fluoro-3-trifluoromethylpyridine 65753-52-8
- Price
- US $1.00/kg
- Min. Order
- 1kg
- Purity
- 98%
- Supply Ability
- 200kg
- Release date
- 2018-12-20